{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T03:56:30Z","timestamp":1794628590956,"version":"4.9.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"11","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2018,4,17]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>In the last decades, the extension of life expectancy and the increased consumption\nof foods rich in saturated fats and added sugars have exposed the general population to emerging\nhealth problems.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title\/>\n<jats:p>\nThe prevalence of metabolic syndrome (MS), composed of a cluster of factors as obesity,\ndyslipidemia, hyperglycemia, and hypertension, is rapidly increasing in industrialized and developing\ncountries leading to precocious onset of age-related diseases. Indeed, oxidative\nstress, accumulation of advanced glycation endproducts, and a chronic low-grade inflammation\nare common features of MS and physiological ageing. In particular, the entire set of MS\nfactors contributes to the development of an inflammatory status named metaflammation,\nwhich has been associated with activation of early innate immune response through the assembling\nof the multiprotein complex inflammasome. The most investigated family of inflammasome\nplatforms is the NOD-like receptor pyridine containing (NLRP) 3, which is activated\nby several exogenous and endogenous stimuli, leading to the sequential cleavage of\ncaspase-1 and IL-1\u03b2, followed by secretion of active IL-1\u03b2. We here collect the most recent\nfindings on NLRP3 activation in MS providing evidence of its central role in disease progression\nand organ dysfunction in target tissues of metaflammation, in particular in cardiovascular,\nhepatic and renal complications, with a focus on oxidative stress and advanced glycation\nendproducts. A wide overview of the most promising strategies for the modulation of NLRP3\nactivation and related metabolic repercussions is also provided, since the finding of specific\npharmacological tools is an urgent requirement to reduce the social and economic burden of\nMS- and elderly-associated diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867324666170407123522","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T07:28:25Z","timestamp":1492068505000},"page":"1294-1310","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome"],"prefix":"10.2174","volume":"25","author":[{"given":"Raffaella","family":"Mastrocola","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Aragno","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Alloatti","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Systems Biology, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Collino","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Penna","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/151415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/151415\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/151415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:59:18Z","timestamp":1608890358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/151415\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,4,17]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867324666170407123522","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2016-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}