{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:43:50Z","timestamp":1789461830633,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2018,1,30]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Homocysteine (Hcy) and hydrogen sulfide (H2S) are important molecules produced\nduring the metabolism of sulfur-containing amino acids. Hcy metabolism is central to\nthe supply of methyl groups that are essential for biological function. Hcy can be either regenerated\nto methionine or metabolized to cysteine, a precursor for glutathione synthesis.\nCystathionine-\u03b2-synthase (CBS) and cystathionine-\u03b3-lyase (CSE) play a crucial role in metabolizing\nHcy to cysteine through the transsulfuration pathway. These two enzymes are\nalso responsible for H2S generation through desulfuration reactions. H2S, at physiological\nlevels serves as a gaseous mediator and has multifaceted effects. Metabolic imbalance of\nHcy and H2S has been implicated in pathological conditions including oxidative stress,\ninflammation, cardiovascular and cerebral dysfunction, fatty liver disease and ischemiareperfusion\ninjury. Organs such as liver, kidney, gut and pancreas contain all the enzymes\nthat are required for Hcy metabolism. The kidney plays an important role in removing\nHcy from the circulation. Hyperhomocysteinemia, a condition of elevated blood Hcy\nlevel, is a common clinical finding in patients with chronic kidney disease (CKD) or acute\nkidney injury (AKI), the latter is often caused by ischemia-reperfusion. This paper reviews\nexiting literatures regarding (1) the role of kidney in regulating Hcy and H2S\nmetabolism; (2) disruption of sulfur-containing amino acid metabolism during ischemiareperfusion;\n(3) impact of metabolic imbalance of Hcy and H2S on kidney function.\nBetter understanding of molecular mechanisms that regulate Hcy and H2S metabolism\nunder physiological and pathophysiological conditions will help improve therapeutic\nstrategies for patients with kidney disease or other organ injuries.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867324666170509145240","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T07:04:12Z","timestamp":1494399852000},"page":"367-377","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Metabolic Imbalance of Homocysteine and Hydrogen Sulfide in Kidney Disease"],"prefix":"10.2174","volume":"25","author":[{"given":"Karmin","family":"O","sequence":"first","affiliation":[{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw L.","family":"Siow","sequence":"additional","affiliation":[{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/152288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/152288\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/152288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T10:00:10Z","timestamp":1608890410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/152288\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,1,30]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867324666170509145240","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,30]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2016-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}