{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:19:48Z","timestamp":1761920388048},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2018,1,30]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Patients with diabetes mellitus have an increased risk of mortality\ndue to cardiovascular complications. Supplementation with specific sulphur-containing\namino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes\nand associated cardiovascular complications.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Observations: <\/jats:title>\n<jats:p>It is well-known that oxidative stress plays an important role in the pathogenesis\nof diabetes-induced cardiovascular disease, which is invariably associated with\nabnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome.\nCysteine and taurine are among the most common sulphur-containing amino acids\nand their cellular levels decline during diabetes that may contribute to the development of\nthe cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular\nand subcellular functions in the heart, they also exhibit antioxidant properties and thus\nmay exert beneficial effects in different pathophysiological conditions.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>It is concluded that reduction of oxidative stress by cysteine and taurine may\nserve as an important mechanism for the attenuation of diabetes-induced subcellular and\nfunctional abnormalities in the heart.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867324666170705115207","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T05:28:27Z","timestamp":1517376507000},"page":"336-345","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids"],"prefix":"10.2174","volume":"25","author":[{"given":"Paramjit S.","family":"Tappia","sequence":"first","affiliation":[{"name":"Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Adameova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naranjan S.","family":"Dhalla","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology, Institute of Cardiovascular Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/153792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/153792\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/153792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T10:00:07Z","timestamp":1608890407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/153792\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,1,30]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867324666170705115207","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,30]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2016-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}