{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:58Z","timestamp":1787314258497,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"35","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2018,12,3]]},"abstract":"\n Background:<\/jats:title>\n The \u2018epidemic\u2019 diffusion of chronic kidney disease (CKD) needs\nthe development of new therapeutic approaches to slow down the progression to end-stage\nrenal disease. Endothelial Progenitor Cells (EPCs) are promising tools for the treatment of\nmany human diseases as they promote the repair of damaged tissues. They were also suggested\nas therapy to repair renal tissue after an injury. Strategies using EPCs to induce a reparative\nprocess with functional restoring of a diseased kidney or to delay CKD are of two\ntypes: direct stem cells infusion or stimulating endogenous release of EPCs. The repair\nprocess following endothelial damage occurs in three steps: 1) mobilization from bone marrow;\n2) homing on the sites of vascular injury; 3) incorporation of the endothelium into the\ninjured blood vessels.\n<P>\nObjective: In this narrative review we pointed our view to the role of EPCs in endothelial\nrepair and the potential in retarding the progression to renal function loss.\n<P>\nConclusions: Physicians need the development of new preventive strategies for detecting\npatients at risk and discover renal damage. In this way they could slow, by a conservative\ntherapy, the evolution of renal disease and decrease associated morbidity. EPCs have instead\nwell recognized reparative capabilities in many organs. We summarized some recent preclinical\nand clinical models of EPCs mobilization during CKD and we emphasized the potential\nuse of EPCs to slow the progression of renal disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/0929867324666170920150134","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T10:28:29Z","timestamp":1542709709000},"page":"4545-4551","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Endothelial Progenitor Cells at the Interface of Chronic Kidney Disease: From Biology to Therapeutic Advancement"],"prefix":"10.2174","volume":"25","author":[{"given":"Giuseppe","family":"Coppolino","sequence":"first","affiliation":[{"name":"Nephrology and Dialysis Unit, \"Pugliese-Ciaccio\" General Hospital, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cernaro","sequence":"additional","affiliation":[{"name":"University of Messina, Department of Internal Medicine and Pharmacology, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordano","family":"Placida","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \"Pugliese-Ciaccio\" General Hospital, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \"Pugliese-Ciaccio\" General Hospital, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Basile","sequence":"additional","affiliation":[{"name":"Unit of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Bolignano","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, CNR - Italian National Council of Research, Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/155746","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/155746\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/155746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T04:49:12Z","timestamp":1608871752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/155746\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":0,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2018,12,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867324666170920150134","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}