{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:44:52Z","timestamp":1783723492267,"version":"3.55.0"},"reference-count":122,"publisher":"Bentham Science Publishers Ltd.","issue":"36","funder":[{"DOI":"10.13039\/100009573","name":"Universidad Nacional de Rosario","doi-asserted-by":"publisher","award":["1BIO490"],"award-info":[{"award-number":["1BIO490"]}],"id":[{"id":"10.13039\/100009573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"Glaxo Smith Kline","doi-asserted-by":"publisher","award":["PICTOGSK 2011-0046"],"award-info":[{"award-number":["PICTOGSK 2011-0046"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"National Agency for Science and Technology, Argentina","doi-asserted-by":"publisher","award":["PICTOGSK 2011-0046"],"award-info":[{"award-number":["PICTOGSK 2011-0046"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edf\u00edca y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 3014-2593"],"award-info":[{"award-number":["PICT 3014-2593"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2019,12,13]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Bromodomains recognize and bind acetyl-lysine residues present in histone and non-histone\nproteins in a specific manner. In the last decade they have raised as attractive targets for drug discovery\nbecause the miss-regulation of human bromodomains was discovered to be involved in the development\nof a large spectrum of diseases. However, targeting eukaryotic pathogens bromodomains\ncontinues to be almost unexplored. We and others have reported the essentiality of diverse bromodomain-\ncontaining proteins in protozoa, offering a new opportunity for the development of antiparasitic\ndrugs, especially for Trypansoma cruzi, the causative agent of Chagas\u2019 disease. Mammalian bromodomains\nwere classified in eight groups based on sequence similarity but parasitic bromodomains are very\ndivergent proteins and are hard to assign them to any of these groups, suggesting that selective inhibitors\ncan be obtained. In this review, we describe the importance of lysine acetylation and bromodomains\nin T. cruzi as well as the current knowledge on mammalian bromodomains. Also, we summarize\nthe myriad of small-molecules under study to treat different pathologies and which of them have been\ntested in trypanosomatids and other protozoa. All the information available led us to propose that\nT. cruzi bromodomains should be considered as important potential targets and the search for smallmolecules\nto inhibit them should be empowered.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867325666181031132007","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T07:58:46Z","timestamp":1540972726000},"page":"6544-6563","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aim for the Readers! Bromodomains As New Targets Against Chagas\u2019 Disease"],"prefix":"10.2174","volume":"26","author":[{"given":"Victoria Lucia","family":"Alonso","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Emilio","family":"Tavernelli","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Pezza","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Cribb","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ritagliati","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Serra","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.molbiopara.2007.07.007","volume":"156","author":"Clayton C.","year":"2007","unstructured":"Clayton C.; Shapira M.; Post-transcriptional regulation of gene expression in trypanosomes and leishmanias. Mol Biochem Parasitol 2007,156(2),93-101","journal-title":"Mol Biochem Parasitol"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1128\/MMBR.00024-10","volume":"74","author":"Daniels J-P.","year":"2010","unstructured":"Daniels J-P.; Gull K.; Wickstead B.; Cell biology of the trypanosome genome. Microbiol Mol Biol Rev 2010,74(4),552-569","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref=3","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/525241","volume":"2010","author":"Mart\u00ednez-Calvillo S.","year":"2010","unstructured":"Mart\u00ednez-Calvillo S.; Vizuet-de-Rueda J.C.; Florencio-Mart\u00ednez L.E.; Manning-Cela R.G.; Figueroa-Angulo E.E.; Gene expression in trypanosomatid parasites. J Biomed Biotechnol 2010,2010","journal-title":"J Biomed Biotechnol"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.micinf.2003.09.005","volume":"5","author":"Campbell D.A.","year":"2003","unstructured":"Campbell D.A.; Thomas S.; Sturm N.R.; Transcription in kinetoplastid protozoa: why be normal? Microbes Infect 2003,5(13),1231-1240","journal-title":"Microbes Infect"},{"key":"ref=5","first-page":"31","volume":"51","author":"De Gaudenzi J.G.","year":"2011","unstructured":"De Gaudenzi J.G.; No\u00e9 G.; Campo V.A.; Frasch A.C.; Cassola A.; Gene expression regulation in trypanosomatids. Essays Biochem 2011,51,31-46","journal-title":"Essays Biochem"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/S1097-2765(03)00143-6","volume":"11","author":"Mart\u00ednez-Calvillo S.","year":"2003","unstructured":"Mart\u00ednez-Calvillo S.; Yan S.; Nguyen D.; Fox M.; Stuart K.; Myler P.J.; Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol Cell 2003,11(5),1291-1299","journal-title":"Mol Cell"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1128\/EC.3.2.506-517.2004","volume":"3","author":"Mart\u00ednez-Calvillo S.","year":"2004","unstructured":"Mart\u00ednez-Calvillo S.; Nguyen D.; Stuart K.; Myler P.J.; Transcription initiation and termination on Leishmania major chromosome 3. Eukaryot Cell 2004,3(2),506-517","journal-title":"Eukaryot Cell"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1093\/nar\/gks1469","volume":"41","author":"Narayanan M.S.","year":"2013","unstructured":"Narayanan M.S.; Rudenko G.; TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes. Nucleic Acids Res 2013,41(5),2981-2992","journal-title":"Nucleic Acids Res"},{"key":"ref=9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003010","volume":"8","author":"Povelones M.L.","year":"2012","unstructured":"Povelones M.L.; Gluenz E.; Dembek M.; Gull K.; Rudenko G.; Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei. PLoS Pathog 2012,8(11)","journal-title":"PLoS Pathog"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.molbiopara.2013.09.005","volume":"191","author":"Anderson B.A.","year":"2013","unstructured":"Anderson B.A.; Wong I.L.K.; Baugh L.; Ramasamy G.; Myler P.J.; Beverley S.M.; Kinetoplastid-specific histone variant functions are conserved in Leishmania major. Mol Biochem Parasitol 2013,191(2),53-57","journal-title":"Mol Biochem Parasitol"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1101\/gad.1790409","volume":"23","author":"Siegel T.N.","year":"2009","unstructured":"Siegel T.N.; Hekstra D.R.; Kemp L.E.; Figueiredo L.M.; Lowell J.E.; Fenyo D.; Wang X.; Dewell S.; Cross G.A.; Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei. Genes Dev 2009,23(9),1063-1076","journal-title":"Genes Dev"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1016\/j.febslet.2006.03.044","volume":"580","author":"Janzen C.J.","year":"2006","unstructured":"Janzen C.J.; Fernandez J.P.; Deng H.; Diaz R.; Hake S.B.; Cross G.A.M.; Unusual histone modifications in Trypanosoma brucei. FEBS Lett 2006,580(9),2306-2310","journal-title":"FEBS Lett"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1021\/acs.jproteome.6b00208","volume":"15","author":"de Jesus T.C.L.","year":"2016","unstructured":"de Jesus T.C.L.; Nunes V.S.; Lopes M. de C.; Martil D.E.; Iwai L.K.; Moretti N.S.; Machado F.C.; de Lima-Stein M.L.; Thiemann O.H.; Elias M.C.; Janzen C.; Schenkman S.; da Cunha J.P.C.; Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi. J Proteome Res 2016,15(6),2039-2051","journal-title":"J Proteome Res"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00412-009-0213-9","volume":"118","author":"Nardelli S.C.","year":"2009","unstructured":"Nardelli S.C.; da Cunha J.P.C.; Motta M.C.M.; Schenkman S.; Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage. Chromosoma 2009,118(4),487-499","journal-title":"Chromosoma"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.pt.2007.04.006","volume":"23","author":"Schenkman S.","year":"2007","unstructured":"Schenkman S.; da Cunha J.P.C.; Response to Horn: Introducing histone modifications in trypanosomes. Trends Parasitol 2007,23(6),242-243","journal-title":"Trends Parasitol"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.molbiopara.2007.07.005","volume":"156","author":"Mandava V.","year":"2007","unstructured":"Mandava V.; Fernandez J.P.; Deng H.; Janzen C.J.; Hake S.B.; Cross G.A.; Histone modifications in Trypanosoma brucei. Mol Biochem Parasitol 2007,156(1),41-50","journal-title":"Mol Biochem Parasitol"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1021\/acs.jproteome.6b00655","volume":"16","author":"Picchi G.F.A.","year":"2017","unstructured":"Picchi G.F.A.; Zulkievicz V.; Krieger M.A.; Zanchin N.T.; Goldenberg S.; de Godoy L.M.F.; Post-translational Modifications of Trypanosoma cruzi Canonical and Variant Histones. J Proteome Res 2017,16(3),1167-1179","journal-title":"J Proteome Res"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1365-3024.2011.01347.x","volume":"34","author":"Choi J.","year":"2012","unstructured":"Choi J.; El-Sayed N.M.; Functional genomics of trypanosomatids. Parasite Immunol 2012,34(2-3),72-79","journal-title":"Parasite Immunol"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"15884","DOI":"10.1074\/jbc.M802081200","volume":"283","author":"Respuela P.","year":"2008","unstructured":"Respuela P.; Ferella M.; Rada-Iglesias A.; Aslund L.; Histone acetylation and methylation at sites initiating divergent polycistronic transcription in Trypanosoma cruzi. J Biol Chem 2008,283(23),15884-15892","journal-title":"J Biol Chem"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1471-2164-10-152","volume":"10","author":"Thomas S.","year":"2009","unstructured":"Thomas S.; Green A.; Sturm N.R.; Campbell D.A.; Myler P.J.; Histone acetylations mark origins of polycistronic transcription in Leishmania major. BMC Genomics 2009,10,152","journal-title":"BMC Genomics"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1128\/EC.05185-11","volume":"10","author":"Ekanayake D.","year":"2011","unstructured":"Ekanayake D.; Sabatini R.; Epigenetic regulation of polymerase II transcription initiation in Trypanosoma cruzi: modulation of nucleosome abundance, histone modification, and polymerase occupancy by O-linked thymine DNA glucosylation. Eukaryot Cell 2011,10(11),1465-1472","journal-title":"Eukaryot Cell"},{"key":"ref=22","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/452934","volume":"2012","author":"Alonso V.L.","year":"2012","unstructured":"Alonso V.L.; Serra E.C.; Lysine acetylation: elucidating the components of an emerging global signaling pathway in trypanosomes. J Biomed Biotechnol 2012,2012","journal-title":"J Biomed Biotechnol"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/mmi.12303","volume":"89","author":"Miao J.","year":"2013","unstructured":"Miao J.; Lawrence M.; Jeffers V.; Zhao F.; Parker D.; Ge Y.; Sullivan W.J.; Jr.; Cui, L. Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Mol Microbiol 2013,89(4),660-675","journal-title":"Mol Microbiol"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1128\/EC.00088-12","volume":"11","author":"Jeffers V.","year":"2012","unstructured":"Jeffers V.; Sullivan W.J.; Jr Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii. Eukaryot Cell 2012,11(6),735-742","journal-title":"Eukaryot Cell"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1021\/acs.jproteome.7b00603","volume":"17","author":"Moretti N.S.","year":"2018","unstructured":"Moretti N.S.; Cestari I.; Anupama A.; Stuart K.; Schenkman S.; Comparative proteomic analysis of lysine acetylation in trypanosomes. J Proteome Res 2018,17(1),374-385","journal-title":"J Proteome Res"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1590\/S0074-02762009000900014","volume":"104","author":"Souza Wd.","year":"2009","unstructured":"Souza Wd.; Structural organization of Trypanosoma cruzi. Mem Inst Oswaldo Cruz 2009,104(Suppl. 1),89-100","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1590\/S0074-02761993000400004","volume":"88","author":"Souto-Padron T.","year":"1993","unstructured":"Souto-Padron T.; Cunha e Silva N.L.; de Souza W.; Acetylated alpha-tubulin in Trypanosoma cruzi: immunocytochemical localization. Mem Inst Oswaldo Cruz 1993,88(4),517-528","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1083\/jcb.104.3.431","volume":"104","author":"Schneider A.","year":"1987","unstructured":"Schneider A.; Sherwin T.; Sasse R.; Russell D.G.; Gull K.; Seebeck T.; Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms. J Cell Biol 1987,104(3),431-438","journal-title":"J Cell Biol"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.mi.41.100187.001015","volume":"41","author":"Opperdoes F.R.","year":"1987","unstructured":"Opperdoes F.R.; Compartmentation of carbohydrate metabolism in trypanosomes. Annu Rev Microbiol 1987,41,127-151","journal-title":"Annu Rev Microbiol"},{"key":"ref=30","first-page":"482","author":"Michels P.A.","year":"2000","unstructured":"Michels P.A.; Hannaert V.; Bringaud F.;  Metabolic aspects of glycosomes in trypanosomatidae - new data and views 2000,482-489","journal-title":"Metabolic aspects of glycosomes in trypanosomatidae - new data and views"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1042\/BJ20150986","volume":"473","author":"Ritagliati C.","year":"2016","unstructured":"Ritagliati C.; Villanova G.V.; Alonso V.L.; Zuma A.A.; Cribb P.; Motta M.C.M.; Serra E.C.; Glycosomal bromodomain factor 1 from Trypanosoma cruzi enhances trypomastigote cell infection and intracellular amastigote growth. Biochem J 2016,473(1),73-85","journal-title":"Biochem J"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/0092-8674(92)90191-E","volume":"68","author":"Tamkun J.W.","year":"1992","unstructured":"Tamkun J.W.; Deuring R.; Scott M.P.; Kissinger M.; Pattatucci A.M.; Kaufman T.C.; Kennison J.A.; brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2\/SWI2. Cell 1992,68(3),561-572","journal-title":"Cell"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman H.M.","year":"2000","unstructured":"Berman H.M.; Westbrook J.; Feng Z.; Gilliland G.; Bhat T.N.; Weissig H.; Shindyalov I.N.; Bourne P.E.; The Protein Data Bank. Nucleic Acids Res 2000,28(1),235-242","journal-title":"Nucleic Acids Res"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/20974","volume":"399","author":"Dhalluin C.","year":"1999","unstructured":"Dhalluin C.; Carlson J.E.; Zeng L.; He C.; Aggarwal A.K.; Zhou M.M.; Structure and ligand of a histone acetyltransferase bromodomain. Nature 1999,399(6735),491-496","journal-title":"Nature"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S1097-2765(03)00528-8","volume":"13","author":"Mujtaba S.","year":"2004","unstructured":"Mujtaba S.; He Y.; Zeng L.; Yan S.; Plotnikova O.; Sachchidanand; Sanchez, R.; Zeleznik-Le, N.J.; Ronai, Z.; Zhou, M.M. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell 2004,13(2),251-263","journal-title":"Mol Cell"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.str.2008.01.010","volume":"16","author":"Zeng L.","year":"2008","unstructured":"Zeng L.; Zhang Q.; Gerona-Navarro G.; Moshkina N.; Zhou M-M.; Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP\/p300. Structure 2008,16(4),643-652","journal-title":"Structure"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.str.2013.10.021","volume":"22","author":"Plotnikov A.N.","year":"2014","unstructured":"Plotnikov A.N.; Yang S.; Zhou T.J.; Rusinova E.; Frasca A.; Zhou M-M.; Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP. Structure 2014,22(2),353-360","journal-title":"Structure"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.cell.2012.02.013","volume":"149","author":"Filippakopoulos P.","year":"2012","unstructured":"Filippakopoulos P.; Picaud S.; Mangos M.; Keates T.; Lambert J-P.; Barsyte-Lovejoy D.; Felletar I.; Volkmer R.; M\u00fcller S.; Pawson T.; Gingras A-C.; Arrowsmith C.H.; Knapp S.; Histone recognition and large-scale structural analysis of the human bromodomain family. Cell 2012,149(1),214-231","journal-title":"Cell"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1128\/MCB.05413-11","volume":"31","author":"Gamsjaeger R.","year":"2011","unstructured":"Gamsjaeger R.; Webb S.R.; Lamonica J.M.; Billin A.; Blobel G.A.; Mackay J.P.; Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3. Mol Cell Biol 2011,31(13),2632-2640","journal-title":"Mol Cell Biol"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.bmc.2011.10.080","volume":"20","author":"Filippakopoulos P.","year":"2012","unstructured":"Filippakopoulos P.; Picaud S.; Fedorov O.; Keller M.; Wrobel M.; Morgenstern O.; Bracher F.; Knapp S.; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg Med Chem 2012,20(6),1878-1886","journal-title":"Bioorg Med Chem"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/cr.2010.43","volume":"20","author":"Charlop-Powers Z.","year":"2010","unstructured":"Charlop-Powers Z.; Zeng L.; Zhang Q.; Zhou M-M.; Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res 2010,20(5),529-538","journal-title":"Cell Res"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.1074\/jbc.M109.062422","volume":"285","author":"Umehara T.","year":"2010","unstructured":"Umehara T.; Nakamura Y.; Jang M.K.; Nakano K.; Tanaka A.; Ozato K.; Padmanabhan B.; Yokoyama S.; Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain. J Biol Chem 2010,285(10),7610-7618","journal-title":"J Biol Chem"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"6141","DOI":"10.1093\/emboj\/19.22.6141","volume":"19","author":"Owen D.J.","year":"2000","unstructured":"Owen D.J.; Ornaghi P.; Yang J.C.; Lowe N.; Evans P.R.; Ballario P.; Neuhaus D.; Filetici P.; Travers A.A.; The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p. EMBO J 2000,19(22),6141-6149","journal-title":"EMBO J"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.bbagrm.2014.03.011","volume":"1839","author":"Sanchez R.","year":"2014","unstructured":"Sanchez R.; Meslamani J.; Zhou M-M.; The bromodomain: from epigenome reader to druggable target. Biochim Biophys Acta 2014,1839(8),676-685","journal-title":"Biochim Biophys Acta"},{"key":"ref=45","first-page":"659","volume":"12","author":"Sanchez R.","year":"2009","unstructured":"Sanchez R.; Zhou M-M.; The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel 2009,12(5),659-665","journal-title":"Curr Opin Drug Discov Devel"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","volume":"44","author":"Finn R.D.","year":"2016","unstructured":"Finn R.D.; Coggill P.; Eberhardt R.Y.; Eddy S.R.; Mistry J.; Mitchell A.L.; Potter S.C.; Punta M.; Qureshi M.; Sangrador-Vegas A.; Salazar G.A.; Tate J.; Bateman A.; The Pfam protein families database: towards a more sustainable future. Nucleic Acids Res 2016,44(D1),D279-D285","journal-title":"Nucleic Acids Res"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1063127","volume":"293","author":"Jenuwein T.","year":"2001","unstructured":"Jenuwein T.; Allis C.D.; Translating the histone code. Science 2001,293(5532),1074-1080","journal-title":"Science"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/nrm.2016.143","volume":"18","author":"Fujisawa T.","year":"2017","unstructured":"Fujisawa T.; Filippakopoulos P.; Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol 2017,18(4),246-262","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref=49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005366","volume":"12","author":"Delcuratolo M.","year":"2016","unstructured":"Delcuratolo M.; Fertey J.; Schneider M.; Schuetz J.; Leiprecht N.; Hudjetz B.; Brodbeck S.; Corall S.; Dreer M.; Schwab R.M.; Grimm M.; Wu S-Y.; Stubenrauch F.; Chiang C-M.; Iftner T.; Papillomavirus-associated tumor formation critically depends on c-fos expression induced by viral protein E2 and bromodomain protein Brd4. PLoS Pathog 2016,12(1)","journal-title":"PLoS Pathog"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.devbrainres.2003.12.011","volume":"149","author":"Crowley T.","year":"2004","unstructured":"Crowley T.; Brunori M.; Rhee K.; Wang X.; Wolgemuth D.J.; Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia. Brain Res Dev Brain Res 2004,149(2),93-101","journal-title":"Brain Res Dev Brain Res"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/mrd.20059","volume":"68","author":"Trousdale R.K.","year":"2004","unstructured":"Trousdale R.K.; Wolgemuth D.J.; Bromodomain containing 2 (Brd2) is expressed in distinct patterns during ovarian folliculogenesis independent of FSH or GDF9 action. Mol Reprod Dev 2004,68(3),261-268","journal-title":"Mol Reprod Dev"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1369\/jhc.7A7340.2007","volume":"56","author":"Liu H.","year":"2008","unstructured":"Liu H.; Li X.; Niu Z.; Zhang L.; Zhou M.; Huang H.; He J.; Zhang W.; Xiao L.; Tang Y.; Wang L.; Li G.; Preparation of polyclonal antibody specific for BRD7 and detection of its expression pattern in the human fetus. J Histochem Cytochem 2008,56(6),531-538","journal-title":"J Histochem Cytochem"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"6828","DOI":"10.1128\/MCB.01297-08","volume":"28","author":"Ullah M.","year":"2008","unstructured":"Ullah M.; Pelletier N.; Xiao L.; Zhao S.P.; Wang K.; Degerny C.; Tahmasebi S.; Cayrou C.; Doyon Y.; Goh S-L.; Champagne N.; C\u00f4t\u00e9 J.; Yang X-J.; Molecular architecture of quartet MOZ\/MORF histone acetyltransferase complexes. Mol Cell Biol 2008,28(22),6828-6843","journal-title":"Mol Cell Biol"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1093\/emboj\/19.15.4123","volume":"19","author":"Zong R.T.","year":"2000","unstructured":"Zong R.T.; Das C.; Tucker P.W.; Regulation of matrix attachment region-dependent, lymphocyte-restricted transcription through differential localization within promyelocytic leukemia nuclear bodies. EMBO J 2000,19(15),4123-4133","journal-title":"EMBO J"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.fgb.2015.01.011","volume":"81","author":"Chang P.","year":"2015","unstructured":"Chang P.; Fan X.; Chen J.; Function and subcellular localization of Gcn5, a histone acetyltransferase in Candida albicans. Fungal Genet Biol 2015,81,132-141","journal-title":"Fungal Genet Biol"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/molbev\/msr121","volume":"28","author":"Tamura K.","year":"2011","unstructured":"Tamura K.; Peterson D.; Peterson N.; Stecher G.; Nei M.; Kumar S.; MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011,28(10),2731-2739","journal-title":"Mol Biol Evol"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1128\/EC.00341-13","volume":"13","author":"Alonso V.L.","year":"2014","unstructured":"Alonso V.L.; Villanova G.V.; Ritagliati C.; Machado Motta M.C.; Cribb P.; Serra E.C.; Trypanosoma cruzi bromodomain factor 3 binds acetylated \u03b1-tubulin and concentrates in the flagellum during metacyclogenesis. Eukaryot Cell 2014,13(6),822-831","journal-title":"Eukaryot Cell"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.ijpara.2008.11.013","volume":"39","author":"Villanova G.V.","year":"2009","unstructured":"Villanova G.V.; Nardelli S.C.; Cribb P.; Magdaleno A.; Silber A.M.; Motta M.C.M.; Schenkman S.; Serra E.; Trypanosoma cruzi bromodomain factor 2 (BDF2) binds to acetylated histones and is accumulated after UV irradiation. Int J Parasitol 2009,39(6),665-673","journal-title":"Int J Parasitol"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1111\/febs.13719","volume":"283","author":"Alonso V.L.","year":"2016","unstructured":"Alonso V.L.; Ritagliati C.; Cribb P.; Cricco J.A.; Serra E.C.; Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors. FEBS J 2016,283(11),2051-2066","journal-title":"FEBS J"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.exppara.2012.01.020","volume":"130","author":"Milagros Camara.","year":"2012","unstructured":"Milagros Camara.; Mde.L.; Bouvier, L.A.; Miranda, M.R.; Pereira, C.A. Identification and validation of Trypanosoma cruzi\u2019s glycosomal adenylate kinase containing a peroxisomal targeting signal. Exp Parasitol 2012,130(4),408-411","journal-title":"Exp Parasitol"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.bbamcr.2015.09.015","volume":"1863","author":"Haanstra J.R.","year":"2016","unstructured":"Haanstra J.R.; Gonz\u00e1lez-Marcano E.B.; Gualdr\u00f3n-L\u00f3pez M.; Michels P.A.M.; Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites. Biochim Biophys Acta 2016,1863(5),1038-1048","journal-title":"Biochim Biophys Acta"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1126\/science.1179689","volume":"327","author":"Zhao S.","year":"2010","unstructured":"Zhao S.; Xu W.; Jiang W.; Yu W.; Lin Y.; Zhang T.; Yao J.; Zhou L.; Zeng Y.; Li H.; Li Y.; Shi J.; An W.; Hancock S.M.; He F.; Qin L.; Chin J.; Yang P.; Chen X.; Lei Q.; Xiong Y.; Guan K-L.; Regulation of cellular metabolism by protein lysine acetylation. Science 2010,327(5968),1000-1004","journal-title":"Science"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"D1019","DOI":"10.2741\/Horn","volume":"6","author":"Horn P.J.","year":"2001","unstructured":"Horn P.J.; Peterson C.L.; The bromodomain: a regulator of ATP-dependent chromatin remodeling? Front Biosci 2001,6,D1019-D1023","journal-title":"Front Biosci"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1042\/BCJ20170619","volume":"474","author":"Yang X.","year":"2017","unstructured":"Yang X.; Wu X.; Zhang J.; Zhang X.; Xu C.; Liao S.; Tu X.; Recognition of hyperacetylated N-terminus of H2AZ by TbBDF2 from Trypanosoma brucei. Biochem J 2017,474(22),3817-3830","journal-title":"Biochem J"},{"key":"ref=65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002316","volume":"13","author":"Schulz D.","year":"2015","unstructured":"Schulz D.; Mugnier M.R.; Paulsen E.M.; Kim H.S.; Chung C.W.; Tough D.F.; Rioja I.; Prinjha R.K.; Papavasiliou F.N.; Debler E.W.; Bromodomain proteins contribute to maintenance of bloodstream form stage identity in the African Trypanosome. PLoS Biol 2015,13(12)","journal-title":"PLoS Biol"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"10150","DOI":"10.1093\/nar\/gks813","volume":"40","author":"Alsford S.","year":"2012","unstructured":"Alsford S.; Horn D.; Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. Nucleic Acids Res 2012,40(20),10150-10160","journal-title":"Nucleic Acids Res"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nchembio.2007.18","volume":"3","author":"Kaida D.","year":"2007","unstructured":"Kaida D.; Motoyoshi H.; Tashiro E.; Nojima T.; Hagiwara M.; Ishigami K.; Watanabe H.; Kitahara T.; Yoshida T.; Nakajima H.; Tani T.; Horinouchi S.; Yoshida M.; Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol 2007,3(9),576-583","journal-title":"Nat Chem Biol"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/nchembio.2007.16","volume":"3","author":"Kotake Y.","year":"2007","unstructured":"Kotake Y.; Sagane K.; Owa T.; Mimori-Kiyosue Y.; Shimizu H.; Uesugi M.; Ishihama Y.; Iwata M.; Mizui Y.; Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol 2007,3(9),570-575","journal-title":"Nat Chem Biol"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/nature09504","volume":"468","author":"Filippakopoulos P.","year":"2010","unstructured":"Filippakopoulos P.; Qi J.; Picaud S.; Shen Y.; Smith W.B.; Fedorov O.; Morse E.M.; Keates T.; Hickman T.T.; Felletar I.; Philpott M.; Munro S.; McKeown M.R.; Wang Y.; Christie A.L.; West N.; Cameron M.J.; Schwartz B.; Heightman T.D.; La Thangue N.; French C.A.; Wiest O.; Kung A.L.; Knapp S.; Bradner J.E.; Selective inhibition of BET bromodomains. Nature 2010,468(7327),1067-1073","journal-title":"Nature"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1021\/jm200108t","volume":"54","author":"Chung C-W.","year":"2011","unstructured":"Chung C-W.; Coste H.; White J.H.; Mirguet O.; Wilde J.; Gosmini R.L.; Delves C.; Magny S.M.; Woodward R.; Hughes S.A.; Boursier E.V.; Flynn H.; Bouillot A.M.; Bamborough P.; Brusq J-M.G.; Gellibert F.J.; Jones E.J.; Riou A.M.; Homes P.; Martin S.L.; Uings I.J.; Toum J.; Clement C.A.; Boullay A-B.; Grimley R.L.; Blandel F.M.; Prinjha R.K.; Lee K.; Kirilovsky J.; Nicodeme E.; Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem 2011,54(11),3827-3838","journal-title":"J Med Chem"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature10509","volume":"478","author":"Dawson M.A.","year":"2011","unstructured":"Dawson M.A.; Prinjha R.K.; Dittmann A.; Giotopoulos G.; Bantscheff M.; Chan W-I.; Robson S.C.; Chung C.W.; Hopf C.; Savitski M.M.; Huthmacher C.; Gudgin E.; Lugo D.; Beinke S.; Chapman T.D.; Roberts E.J.; Soden P.E.; Auger K.R.; Mirguet O.; Doehner K.; Delwel R.; Burnett A.K.; Jeffrey P.; Drewes G.; Lee K.; Huntly B.J.P.; Kouzarides T.; Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011,478(7370),529-533","journal-title":"Nature"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1177\/1087057111421372","volume":"16","author":"Chung C.W.","year":"2011","unstructured":"Chung C.W.; Witherington J.; Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions. J Biomol Screen 2011,16(10),1170-1185","journal-title":"J Biomol Screen"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.chembiol.2010.12.021","volume":"18","author":"Borah J.C.","year":"2011","unstructured":"Borah J.C.; Mujtaba S.; Karakikes I.; Zeng L.; Muller M.; Patel J.; Moshkina N.; Morohashi K.; Zhang W.; Gerona-Navarro G.; Hajjar R.J.; Zhou M-M.; A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol 2011,18(4),531-541","journal-title":"Chem Biol"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1126\/science.274.5292.1531","volume":"274","author":"Shuker S.B.","year":"1996","unstructured":"Shuker S.B.; Hajduk P.J.; Meadows R.P.; Fesik S.W.; Discovering high-affinity ligands for proteins: SAR by NMR. Science 1996,274(5292),1531-1534","journal-title":"Science"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.2174\/156802607782341073","volume":"7","author":"Neumann T.","year":"2007","unstructured":"Neumann T.; Junker H-D.; Schmidt K.; Sekul R.; SPR-based fragment screening: advantages and applications. Curr Top Med Chem 2007,7(16),1630-1642","journal-title":"Curr Top Med Chem"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1038\/nprot.2007.321","volume":"2","author":"Niesen F.H.","year":"2007","unstructured":"Niesen F.H.; Berglund H.; Vedadi M.; The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat Protoc 2007,2(9),2212-2221","journal-title":"Nat Protoc"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"20523","DOI":"10.1073\/pnas.0708800104","volume":"104","author":"Fedorov O.","year":"2007","unstructured":"Fedorov O.; Marsden B.; Pogacic V.; Rellos P.; M\u00fcller S.; Bullock A.N.; Schwaller J.; Sundstr\u00f6m M.; Knapp S.; A systematic interaction map of validated kinase inhibitors with Ser\/Thr kinases. Proc Natl Acad Sci USA 2007,104(51),20523-20528","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature09589","volume":"468","author":"Nicodeme E.","year":"2010","unstructured":"Nicodeme E.; Jeffrey K.L.; Schaefer U.; Beinke S.; Dewell S.; Chung C-W.; Chandwani R.; Marazzi I.; Wilson P.; Coste H.; White J.; Kirilovsky J.; Rice C.M.; Lora J.M.; Prinjha R.K.; Lee K.; Tarakhovsky A.; Suppression of inflammation by a synthetic histone mimic. Nature 2010,468(7327),1119-1123","journal-title":"Nature"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1039\/c1mb05099k","volume":"7","author":"Philpott M.","year":"2011","unstructured":"Philpott M.; Yang J.; Tumber T.; Fedorov O.; Uttarkar S.; Filippakopoulos P.; Picaud S.; Keates T.; Felletar I.; Ciulli A.; Knapp S.; Heightman T.D.; Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. Mol Biosyst 2011,7(10),2899-2908","journal-title":"Mol Biosyst"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1039\/C7MD00083A","volume":"8","author":"Chen Z.","year":"2017","unstructured":"Chen Z.; Zhang H.; Liu S.; Xie Y.; Jiang H.; Lu W.; Xu H.; Yue L.; Zhang Y.; Ding H.; Zheng M.; Yu K.; Chen K.; Jiang H.; Luo C.; Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay. MedChemComm 2017,8(6),1322-1331","journal-title":"MedChemComm"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1517\/13543776.2014.859244","volume":"24","author":"Garnier J-M.","year":"2014","unstructured":"Garnier J-M.; Sharp P.P.; Burns C.J.; BET bromodomain inhibitors: A patent review. Expert Opin Ther Pat 2014,24(2),185-199","journal-title":"Expert Opin Ther Pat"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1021\/jm201283q","volume":"55","author":"Bamborough P.","year":"2012","unstructured":"Bamborough P.; Diallo H.; Goodacre J.D.; Gordon L.; Lewis A.; Seal J.T.; Wilson D.M.; Woodrow M.D.; Chung C.W.; Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. J Med Chem 2012,55(2),587-596","journal-title":"J Med Chem"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1021\/ja107761h","volume":"133","author":"Gerona-Navarro G.","year":"2011","unstructured":"Gerona-Navarro G.; Yoel-Rodr\u00edguez; Mujtaba, S.; Frasca, A.; Patel, J.; Zeng, L.; Plotnikov, A.N.; Osman, R.; Zhou, M.M. Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors. J Am Chem Soc 2011,133(7),2040-2043","journal-title":"J Am Chem Soc"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1002\/cmdc.201300499","volume":"9","author":"Hu P.","year":"2014","unstructured":"Hu P.; Wang X.; Zhang B.; Zhang S.; Wang Q.; Wang Z.; Fluorescence polarization for the evaluation of small-molecule inhibitors of PCAF\u2005BRD\/Tat-AcK50 association. ChemMedChem 2014,9(5),928-931","journal-title":"ChemMedChem"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1111\/febs.13719","volume":"283","author":"Alonso V.L.","year":"2016","unstructured":"Alonso V.L.; Ritagliati C.; Cribb P.; Cricco J.; Serra E.; Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects parasite differentiation and protects it against bromodomain inhibitors. FEBS J 2016,283(11),2051-2066","journal-title":"FEBS J"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1021\/acscombsci.7b00172","volume":"20","author":"Ramallo I.A.","year":"2018","unstructured":"Ramallo I.A.; Alonso V.L.; Rua F.; Serra E.; Furlan R.L.E.; A bioactive Trypanosoma cruzi Bromodomain inhibitor from chemically engineered extracts. ACS Comb Sci 2018,20(4),220-228","journal-title":"ACS Comb Sci"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1021\/acsmedchemlett.8b00247","volume":"9","author":"Garc\u00eda P.","year":"2018","unstructured":"Garc\u00eda P.; Alonso V.L.; Serra E.; Escalante A.M.; Furlan R.L.E.; Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry. ACS Med Chem Lett 2018,9(10),1002-1006","journal-title":"ACS Med Chem Lett"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1016\/j.bmcl.2012.01.125","volume":"22","author":"Mirguet O.","year":"2012","unstructured":"Mirguet O.; Lamotte Y.; Donche F.; Toum J.; Gellibert F.; Bouillot A.; Gosmini R.; Nguyen V-L.; Delann\u00e9e D.; Seal J.; Blandel F.; Boullay A-B.; Boursier E.; Martin S.; Brusq J-M.; Krysa G.; Riou A.; Tellier R.; Costaz A.; Huet P.; Dudit Y.; Trottet L.; Kirilovsky J.; Nicodeme E.; From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151. Bioorg Med Chem Lett 2012,22(8),2963-2967","journal-title":"Bioorg Med Chem Lett"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.chembiol.2011.02.009","volume":"18","author":"Ito T.","year":"2011","unstructured":"Ito T.; Umehara T.; Sasaki K.; Nakamura Y.; Nishino N.; Terada T.; Shirouzu M.; Padmanabhan B.; Yokoyama S.; Ito A.; Yoshida M.; Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem Biol 2011,18(4),495-507","journal-title":"Chem Biol"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1756-8935-7-14","volume":"7","author":"Philpott M.","year":"2014","unstructured":"Philpott M.; Rogers C.M.; Yapp C.; Wells C.; Lambert J-P.; Strain-Damerell C.; Burgess-Brown N.A.; Gingras A-C.; Knapp S.; M\u00fcller S.; Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. Epigenetics Chromatin 2014,7,14","journal-title":"Epigenetics Chromatin"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1093\/bioinformatics\/btu052","volume":"30","author":"Meslamani J.","year":"2014","unstructured":"Meslamani J.; Smith S.G.; Sanchez R.; Zhou M-M.; ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains. Bioinformatics 2014,30(10),1481-1483","journal-title":"Bioinformatics"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"9393","DOI":"10.1021\/jm300915b","volume":"55","author":"Hewings D.S.","year":"2012","unstructured":"Hewings D.S.; Rooney T.P.C.; Jennings L.E.; Hay D.A.; Schofield C.J.; Brennan P.E.; Knapp S.; Conway S.J.; Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. J Med Chem 2012,55(22),9393-9413","journal-title":"J Med Chem"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1021\/cb500996u","volume":"10","author":"Brand M.","year":"2015","unstructured":"Brand M.; Measures A.R.; Wilson B.G.; Cortopassi W.A.; Alexander R.; H\u00f6ss M.; Hewings D.S.; Rooney T.P.C.; Paton R.S.; Conway S.J.; Small molecule inhibitors of bromodomain-acetyl-lysine interactions. ACS Chem Biol 2015,10(1),22-39","journal-title":"ACS Chem Biol"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.cbpa.2016.05.028","volume":"33","author":"Theodoulou N.H.","year":"2016","unstructured":"Theodoulou N.H.; Tomkinson N.C.; Prinjha R.K.; Humphreys P.G.; Clinical progress and pharmacology of small molecule bromodomain inhibitors. Curr Opin Chem Biol 2016,33,58-66","journal-title":"Curr Opin Chem Biol"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1021\/jm401088k","volume":"56","author":"Mirguet O.","year":"2013","unstructured":"Mirguet O.; Gosmini R.; Toum J.; Cl\u00e9ment C.A.; Barnathan M.; Brusq J-M.; Mordaunt J.E.; Grimes R.M.; Crowe M.; Pineau O.; Ajakane M.; Daugan A.; Jeffrey P.; Cutler L.; Haynes A.C.; Smithers N.N.; Chung C.W.; Bamborough P.; Uings I.J.; Lewis A.; Witherington J.; Parr N.; Prinjha R.K.; Nicod\u00e8me E.; Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem 2013,56(19),7501-7515","journal-title":"J Med Chem"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"8111","DOI":"10.1021\/jm5010539","volume":"57","author":"Gosmini R.","year":"2014","unstructured":"Gosmini R.; Nguyen V.L.; Toum J.; Simon C.; Brusq J-M.G.; Krysa G.; Mirguet O.; Riou-Eymard A.M.; Boursier E.V.; Trottet L.; Bamborough P.; Clark H.; Chung C.W.; Cutler L.; Demont E.H.; Kaur R.; Lewis A.J.; Schilling M.B.; Soden P.E.; Taylor S.; Walker A.L.; Walker M.D.; Prinjha R.K.; Nicod\u00e8me E.; The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor. J Med Chem 2014,57(19),8111-8131","journal-title":"J Med Chem"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"17698","DOI":"10.18632\/oncotarget.4131","volume":"6","author":"Coud\u00e9 M-M.","year":"2015","unstructured":"Coud\u00e9 M-M.; Braun T.; Berrou J.; Dupont M.; Bertrand S.; Masse A.; Raffoux E.; Itzykson R.; Delord M.; Riveiro M.E.; Herait P.; Baruchel A.; Dombret H.; Gardin C.; BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget 2015,6(19),17698-17712","journal-title":"Oncotarget"},{"key":"ref=98","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.396","volume":"5","author":"Wong C.","year":"2014","unstructured":"Wong C.; Laddha S.V.; Tang L.; Vosburgh E.; Levine A.J.; Normant E.; Sandy P.; Harris C.R.; Chan C.S.; Xu E.Y.; The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis 2014,5","journal-title":"Cell Death Dis"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"7498","DOI":"10.1021\/jm4014407","volume":"56","author":"Zhao Y.","year":"2013","unstructured":"Zhao Y.; Yang C-Y.; Wang S.; The making of I-BET762, a BET bromodomain inhibitor now in clinical development. J Med Chem 2013,56(19),7498-7500","journal-title":"J Med Chem"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1158\/1541-7786.MCR-15-0472","volume":"14","author":"Asangani I.A.","year":"2016","unstructured":"Asangani I.A.; Wilder-Romans K.; Dommeti V.L.; Krishnamurthy P.M.; Apel I.J.; Escara-Wilke J.; Plymate S.R.; Navone N.M.; Wang S.; Feng F.Y.; Chinnaiyan A.M.; BET bromodomain inhibitors enhance efficacy and disrupt resistance to AR antagonists in the treatment of prostate cancer. Mol Cancer Res 2016,14(4),324-331","journal-title":"Mol Cancer Res"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1002\/ijc.30256","volume":"139","author":"Berenguer-Daiz\u00e9 C.","year":"2016","unstructured":"Berenguer-Daiz\u00e9 C.; Astorgues-Xerri L.; Odore E.; Cayol M.; Cvitkovic E.; Noel K.; Bekradda M.; MacKenzie S.; Rezai K.; Lokiec F.; Riveiro M.E.; Ouafik L.; OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models. Int J Cancer 2016,139(9),2047-2055","journal-title":"Int J Cancer"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s40262-015-0327-6","volume":"55","author":"Odore E.","year":"2016","unstructured":"Odore E.; Lokiec F.; Cvitkovic E.; Bekradda M.; Herait P.; Bourdel F.; Kahatt C.; Raffoux E.; Stathis A.; Thieblemont C.; Quesnel B.; Cunningham D.; Riveiro M.E.; Reza\u00ef K.; Phase I.; Phase I population pharmacokinetic assessment of the oral bromodomain inhibitor otx015 in patients with haematologic malignancies. Clin Pharmacokinet 2016,55(3),397-405","journal-title":"Clin Pharmacokinet"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1038\/leu.2014.106","volume":"28","author":"Moros A.","year":"2014","unstructured":"Moros A.; Rodr\u00edguez V.; Saborit-Villarroya I.; Montraveta A.; Balsas P.; Sandy P.; Mart\u00ednez A.; Wiestner A.; Normant E.; Campo E.; P\u00e9rez-Gal\u00e1n P.; Colomer D.; Rou\u00e9 G.; Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma. Leukemia 2014,28(10),2049-2059","journal-title":"Leukemia"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.cell.2013.05.041","volume":"153","author":"King B.","year":"2013","unstructured":"King B.; Trimarchi T.; Reavie L.; Xu L.; Mullenders J.; Ntziachristos P.; Aranda-Orgilles B.; Perez-Garcia A.; Shi J.; Vakoc C.; Sandy P.; Shen S.S.; Ferrando A.; Aifantis I.; The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 2013,153(7),1552-1566","journal-title":"Cell"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"9308","DOI":"10.1021\/ja412434f","volume":"136","author":"Hay D.A.","year":"2014","unstructured":"Hay D.A.; Fedorov O.; Martin S.; Singleton D.C.; Tallant C.; Wells C.; Picaud S.; Philpott M.; Monteiro O.P.; Rogers C.M.; Conway S.J.; Rooney T.P.C.; Tumber A.; Yapp C.; Filippakopoulos P.; Bunnage M.E.; M\u00fcller S.; Knapp S.; Schofield C.J.; Brennan P.E.; Discovery and optimization of small-molecule ligands for the CBP\/p300 bromodomains. J Am Chem Soc 2014,136(26),9308-9319","journal-title":"J Am Chem Soc"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"10768","DOI":"10.1073\/pnas.1501956112","volume":"112","author":"Hammitzsch A.","year":"2015","unstructured":"Hammitzsch A.; Tallant C.; Fedorov O.; O\u2019Mahony A.; Brennan P.E.; Hay D.A.; Martinez F.O.; Al-Mossawi M.H.; de Wit J.; Vecellio M.; Wells C.; Wordsworth P.; M\u00fcller S.; Knapp S.; Bowness P.; CBP30, a selective CBP\/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci USA 2015,112(34),10768-10773","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1016\/j.bmcl.2012.02.041","volume":"22","author":"Seal J.","year":"2012","unstructured":"Seal J.; Lamotte Y.; Donche F.; Bouillot A.; Mirguet O.; Gellibert F.; Nicodeme E.; Krysa G.; Kirilovsky J.; Beinke S.; McCleary S.; Rioja I.; Bamborough P.; Chung C-W.; Gordon L.; Lewis T.; Walker A.L.; Cutler L.; Lugo D.; Wilson D.M.; Witherington J.; Lee K.; Prinjha R.K.; Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett 2012,22(8),2968-2972","journal-title":"Bioorg Med Chem Lett"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1158\/2159-8290.CD-12-0418","volume":"3","author":"Puissant A.","year":"2013","unstructured":"Puissant A.; Frumm S.M.; Alexe G.; Bassil C.F.; Qi J.; Chanthery Y.H.; Nekritz E.A.; Zeid R.; Gustafson W.C.; Greninger P.; Garnett M.J.; McDermott U.; Benes C.H.; Kung A.L.; Weiss W.A.; Bradner J.E.; Stegmaier K.; Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov 2013,3(3),308-323","journal-title":"Cancer Discov"},{"key":"ref=109","author":"Xiao Y.","unstructured":"Xiao Y.; Shanghui L.; Xiaoming T.;  Trypanosoma brucei compounds can kill its application in the treatment of trypanosomiasis"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"e00229","DOI":"10.1128\/mSphere.00229-16","volume":"2","author":"Jeffers V.","year":"2017","unstructured":"Jeffers V.; Kamau E.T.; Srinivasan A.R.; Harper J.; Sankaran P.; Post S.E.; Varberg J.M.; Sullivan W.J.; Boyle J.P.; TgPRELID, a mitochondrial protein linked to multidrug resistance in the parasite. Toxoplasma gondii. MSphere 2017,2(1),e00229-e16","journal-title":"MSphere"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/j.jacc.2010.02.035","volume":"55","author":"Bailey D.","year":"2010","unstructured":"Bailey D.; Jahagirdar R.; Gordon A.; Hafiane A.; Campbell S.; Chatur S.; Wagner G.S.; Hansen H.C.; Chiacchia F.S.; Johansson J.; Krimbou L.; Wong N.C.W.; Genest J.; RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo. J Am Coll Cardiol 2010,55(23),2580-2589","journal-title":"J Am Coll Cardiol"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"19754","DOI":"10.1073\/pnas.1310658110","volume":"110","author":"Picaud S.","year":"2013","unstructured":"Picaud S.; Wells C.; Felletar I.; Brotherton D.; Martin S.; Savitsky P.; Diez-Dacal B.; Philpott M.; Bountra C.; Lingard H.; Fedorov O.; M\u00fcller S.; Brennan P.E.; Knapp S.; Filippakopoulos P.; RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci USA 2013,110(49),19754-19759","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"9831","DOI":"10.1021\/jm3010515","volume":"55","author":"Fish P.V.","year":"2012","unstructured":"Fish P.V.; Filippakopoulos P.; Bish G.; Brennan P.E.; Bunnage M.E.; Cook A.S.; Federov O.; Gerstenberger B.S.; Jones H.; Knapp S.; Marsden B.; Nocka K.; Owen D.R.; Philpott M.; Picaud S.; Primiano M.J.; Ralph M.J.; Sciammetta N.; Trzupek J.D.; Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem 2012,55(22),9831-9837","journal-title":"J Med Chem"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1158\/0008-5472.CAN-12-3292","volume":"73","author":"Picaud S.","year":"2013","unstructured":"Picaud S.; Da Costa D.; Thanasopoulou A.; Filippakopoulos P.; Fish P.V.; Philpott M.; Fedorov O.; Brennan P.; Bunnage M.E.; Owen D.R.; Bradner J.E.; Taniere P.; O\u2019Sullivan B.; M\u00fcller S.; Schwaller J.; Stankovic T.; Knapp S.; PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains. Cancer Res 2013,73(11),3336-3346","journal-title":"Cancer Res"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1021\/acs.jmedchem.5b00209","volume":"59","author":"Chen P.","year":"2016","unstructured":"Chen P.; Chaikuad A.; Bamborough P.; Bantscheff M.; Bountra C.; Chung C-W.; Fedorov O.; Grandi P.; Jung D.; Lesniak R.; Lindon M.; M\u00fcller S.; Philpott M.; Prinjha R.; Rogers C.; Selenski C.; Tallant C.; Werner T.; Willson T.M.; Knapp S.; Drewry D.H.; Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B. J Med Chem 2016,59(4),1410-1424","journal-title":"J Med Chem"},{"key":"ref=116","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600760","volume":"2","author":"Picaud S.","year":"2016","unstructured":"Picaud S.; Leonards K.; Lambert J-P.; Dovey O.; Wells C.; Fedorov O.; Monteiro O.; Fujisawa T.; Wang C-Y.; Lingard H.; Tallant C.; Nikbin N.; Guetzoyan L.; Ingham R.; Ley S.V.; Brennan P.; Muller S.; Samsonova A.; Gingras A-C.; Schwaller J.; Vassiliou G.; Knapp S.; Filippakopoulos P.; Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv 2016,2(10)","journal-title":"Sci Adv"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1021\/jm401568s","volume":"57","author":"Fedorov O.","year":"2014","unstructured":"Fedorov O.; Lingard H.; Wells C.; Monteiro O.P.; Picaud S.; Keates T.; Yapp C.; Philpott M.; Martin S.J.; Felletar I.; Marsden B.D.; Filippakopoulos P.; M\u00fcller S.; Knapp S.; Brennan P.E.; [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. J Med Chem 2014,57(2),462-476","journal-title":"J Med Chem"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"94104","DOI":"10.18632\/oncotarget.21585","volume":"8","author":"Pan H.","year":"2017","unstructured":"Pan H.; Lu P.; Shen Y.; Wang Y.; Jiang Z.; Yang X.; Zhong Y.; Yang H.; Khan I.U.; Zhou M.; Li B.; Zhang Z.; Xu J.; Lu H.; Zhu H.; The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells. Oncotarget 2017,8(55),94104-94116","journal-title":"Oncotarget"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1021\/acs.jmedchem.5b01882","volume":"59","author":"Albrecht B.K.","year":"2016","unstructured":"Albrecht B.K.; Gehling V.S.; Hewitt M.C.; Vaswani R.G.; C\u00f4t\u00e9 A.; Leblanc Y.; Nasveschuk C.G.; Bellon S.; Bergeron L.; Campbell R.; Cantone N.; Cooper M.R.; Cummings R.T.; Jayaram H.; Joshi S.; Mertz J.A.; Neiss A.; Normant E.; O\u2019Meara M.; Pardo E.; Poy F.; Sandy P.; Supko J.; Sims R.J.; Harmange J-C.; Taylor A.M.; Audia J.E.; Identification of a benzoisoxazoloazepine inhibitor (CPI-0610) of the bromodomain and extra-terminal (BET) family as a candidate for human clinical trials. J Med Chem 2016,59(4),1330-1339","journal-title":"J Med Chem"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1038\/leu.2016.355","volume":"31","author":"Siu K.T.","year":"2017","unstructured":"Siu K.T.; Ramachandran J.; Yee A.J.; Eda H.; Santo L.; Panaroni C.; Mertz J.A.; Sims Iii R.J.; Cooper M.R.; Raje N.; Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma. Leukemia 2017,31(8),1760-1769","journal-title":"Leukemia"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"8369","DOI":"10.1021\/acs.jmedchem.7b00746","volume":"60","author":"McDaniel K.F.","year":"2017","unstructured":"McDaniel K.F.; Wang L.; Soltwedel T.; Fidanze S.D.; Hasvold L.A.; Liu D.; Mantei R.A.; Pratt J.K.; Sheppard G.S.; Bui M.H.; Faivre E.J.; Huang X.; Li L.; Lin X.; Wang R.; Warder S.E.; Wilcox D.; Albert D.H.; Magoc T.J.; Rajaraman G.; Park C.H.; Hutchins C.W.; Shen J.J.; Edalji R.P.; Sun C.C.; Martin R.; Gao W.; Wong S.; Fang G.; Elmore S.W.; Shen Y.; Kati W.M.; Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075\/Mivebresib), a potent and orally available bromodomain and extraterminal domain (BET). J Med Chem 2017,60(20),8369-8384","journal-title":"J Med Chem"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1158\/1538-7445.AM2017-5080","volume":"77","author":"V\u00e1zquez R.","year":"2017","unstructured":"V\u00e1zquez R.; Civenni G.; Marchetti M.; Zadic S.; Liu P.; Ruggeri B.; Carbone G.M.; Catapano C.V.; Abstract 5080: BET inhibitors INCB054329 and INCB057643 display significant activity in androgen-independent prostate cancer models. Cancer Res 2017,77,5080-5080","journal-title":"Cancer Res"}],"container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/166814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T07:39:00Z","timestamp":1578555540000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/166814\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":122,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2019,12,13]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867325666181031132007","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}