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Hepatocytes with their\nparticular regenerative features are normally in a quiescent state, and, autophagy controls the accumulation\nof excess products, therefore the liver serves as a basic model for the study of autophagy.\nImpairment of autophagy in the liver causes the accumulation of damaged organelles, misfolded\nproteins and exceeded lipids in hepatocytes as seen in metabolic diseases. In this review, we introduce\nautoimmune hepatitis in association with autophagy signaling. We also discuss some genes and\nproteins of autophagy, their regulatory roles in the activation of hepatic stellate cells and the importance\nof lipophagy and tyrosine kinase in hepatic fibrogenesis. In order to provide a comprehensive\noverview of the regulatory role of autophagy in autoimmune hepatitis, the pathway analysis of autophagy\nin autoimmune hepatitis is also included in this article.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867326666190402120231","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T09:41:52Z","timestamp":1554802912000},"page":"6073-6095","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Autoimmune Hepatitis and Stellate Cells: An Insight into the Role of Autophagy"],"prefix":"10.2174","volume":"27","author":[{"given":"Shahram","family":"Golbabapour","sequence":"first","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Bagheri-Lankarani","sequence":"additional","affiliation":[{"name":"Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Ghavami","sequence":"additional","affiliation":[{"name":"Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Geramizadeh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical school of Shiraz University, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1002\/hep.23584","volume":"51","author":"Manns M.P.","year":"2010","unstructured":"Manns M.P.; Czaja A.J.; Gorham J.D.; Krawitt E.L.; Mieli-Vergani G.; Vergani D.; Vierling J.M.; American association for the study of liver diseases. 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