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The mutation leads to the abnormal expansion of the production of\nthe polyglutamine tract (polyQ) resulting in the form of an unstable Huntingtin protein commonly\nreferred to as mutant Huntingtin. Mutant Huntingtin is the cause of the complex neurological metabolic\nalteration of Huntington\u2019s disease, resulting in both the loss of all the functions of normal\nHuntingtin and the genesis of abnormal interactions due to the presence of this mutation. One of the\nproblems arising from the misfolded Huntingtin is the increase in oxidative stress, which is common\nin many neurological diseases such as Alzheimer\u2019s, Parkinson\u2019s, Amyotrophic Lateral Sclerosis and\nCreutzfeldt-Jakob disease. In the last few years, the use of antioxidants had a strong incentive to find\nvalid therapies for defence against neurodegenerations. Although further studies are needed, the use\nof antioxidant mixtures to counteract neuronal damages seems promising.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867326666190621101909","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T13:20:11Z","timestamp":1561123211000},"page":"5137-5158","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reviewing Biochemical Implications of Normal and Mutated Huntingtin in Huntington\u2019s Disease"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-3392","authenticated-orcid":true,"given":"Ester","family":"Tellone","sequence":"first","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno d\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3806-3205","authenticated-orcid":true,"given":"Antonio","family":"Galtieri","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno d\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-2597","authenticated-orcid":true,"given":"Silvana","family":"Ficarra","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno d\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.arr.2014.01.004","volume":"14(100)","author":"Reeve,A.","year":"2014","unstructured":"Reeve,A.; Simcox,E.; Turnbull, D. 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