{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:28:54Z","timestamp":1784719734278,"version":"3.55.0"},"reference-count":70,"publisher":"Bentham Science Publishers Ltd.","issue":"36","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2020,11,4]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The management of pain in patients with rheumatoid arthritis (RA) is a\ncomplex subject due to the autoimmune nature of the pathology. Studies have shown that chemical\nmediators play a fundamental role in the determination, susceptibility and modulation of pain at\ndifferent levels of the central and peripheral nervous system, resulting in interesting novel molecular\ntargets to mitigate pain in patients with RA. However, due to the complexity of pain physiology in\nRA cand the many chemical mediators, the results of several studies are controversial.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of this study was to identify the chemical mediators that are able to modulate\npain in RA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method:<\/jats:title>\n<jats:p>In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science\nCitation index for studies that evaluated the expression of chemical mediators on the modulation of\npain in RA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Few studies have highlighted the importance of the expression of some chemical mediators\nthat modulate pain in patients with rheumatoid arthritis. The expression of TRPV1, ASIC-3, and\nTDV8 encode ionic channels in RA and modulates pain, likewise, the transcription factors in RA,\nsuch as TNF\u03b1, TGF-\u03b21, IL-6, IL-10, IFN-\u03b3, IL-1b, mTOR, p21, caspase 3, EDNRB, CGRPCALCB,\nCGRP-CALCA, and TAC1 are also directly involved in pain perception.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The expression of all chemical mediators is directly related to RA and the modulation\nof pain by a complex intra and extracellular signaling pathway, however, transcription factors are\ninvolved in modulating acute pain, while the ionic channels are involved in chronic pain in RA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867326666190816225348","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T03:47:51Z","timestamp":1566013671000},"page":"6208-6218","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemical Mediators\u2019 Expression Associated with the Modulation of Pain in Rheumatoid Arthritis"],"prefix":"10.2174","volume":"27","author":[{"given":"Jos\u00e9 Luis","family":"Cortes-Altamirano","sequence":"first","affiliation":[{"name":"Neuropharmacology, Departament of Neurosciences, Instituto Nacional de Rehabilitacion \u201cLuis Guillermo Ibarra Ibarra\u201d, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Del. Tlalpan, 14389 Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abril","family":"Morraz-Varela","sequence":"additional","affiliation":[{"name":"Neuropharmacology, Departament of Neurosciences, Instituto Nacional de Rehabilitacion \u201cLuis Guillermo Ibarra Ibarra\u201d, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Del. Tlalpan, 14389 Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Reyes-Long","sequence":"additional","affiliation":[{"name":"Neuropharmacology, Departament of Neurosciences, Instituto Nacional de Rehabilitacion \u201cLuis Guillermo Ibarra Ibarra\u201d, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Del. 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