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MicroRNAs are known as oncogenes and tumor suppressors\nin CLL which may also serve as markers of onset and progression of the disease. The most\nprevalent form of leukemia diagnosed in adults in the western world, chronic lymphocytic leukemia,\naccounts for one-third of all leukemias. CLL is characterized by the presence of B Cell Malignant\nClones in secondary lymphoid tissues, peripheral blood and bone marrow. The precise etiology of\nCLL is remained to be known, however, a number of Chromosomal Abnormalities such as deletions\nof 13q14.3, 11q and 17p and trisomy 12 have been detected. In this review, we offer our prospect on\nhow miRNAs are involved in the CLL pathogenesis and disease progression. Further understanding\nof the underlying mechanisms and regulation of CLL pathogenesis has underscored the need for\nfurther research regarding their role in this disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867326666190911114842","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T09:41:45Z","timestamp":1569231705000},"page":"282-297","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of microRNAs in Chronic Lymphocytic Leukemia Pathogenesis"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-1623","authenticated-orcid":true,"given":"Ehsan","family":"Javandoost","sequence":"first","affiliation":[{"name":"Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-2949","authenticated-orcid":true,"given":"Ehsan","family":"Firoozi-Majd","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-5836","authenticated-orcid":true,"given":"Hosein","family":"Rostamian","sequence":"additional","affiliation":[{"name":"Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-1012","authenticated-orcid":true,"given":"Mohammad","family":"Khakpoor- Koosheh","sequence":"additional","affiliation":[{"name":"Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-2565","authenticated-orcid":true,"given":"Hamid Reza","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nrclinonc.2009.72","volume":"6","author":"Pleyer L.","year":"2009","unstructured":"Pleyer L.; Egle A.; Hartmann T.N.; Greil R.; Molecular and cellular mechanisms of CLL: novel therapeutic approaches. 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