{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:47:51Z","timestamp":1790257671545,"version":"4.1.0"},"reference-count":130,"publisher":"Bentham Science Publishers Ltd.","issue":"37","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2020,11,6]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Chronic Liver Disorders (CLD), caused by the lifestyle patterns like alcoholism\nor by non-alcoholic fatty liver disease or because of virus-mediated hepatitis, affect a large population\nfraction across the world. CLD progresses into end-stage diseases with a high mortality rate. Liver\ntransplant is the only approved treatment available for such end-stage disease patients. However, the\nnumber of liver transplants is limited due to the limited availability of suitable donors and the extremely\nhigh cost of performing the procedure. Under such circumstances, Stem Cell (SC) mediated\nliver regeneration has emerged as a potential therapeutic alternative approach.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This review aims to critically analyze the current status and future prospects of stem cellbased\ninterventions for end-stage liver diseases. The clinical studies undertaken, the mechanism underlying\ntherapeutic effects and future directions have been examined.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title> Method:<\/jats:title>\n<jats:p>The clinical trial databases were searched at https:\/\/clinicaltrials.gov.in and\nhttp:\/\/www.isrctn.com to identify randomized, non-randomized and controlled studies undertaken with\nkeywords such as \u201cliver disorder and Mesenchymal Stem Cells (MSCs)\u201d, \u201cliver cirrhosis and MSCs\u201d\nand \u201cliver disorder and SCs\u201d. Furthermore, https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/ database was also\nexplored with similar keywords for finding the available reports and their critical analyses.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The search results yielded a significant number of studies that used bone marrow-derived stem\ncells, MSCs and hepatocytes. The studies clearly indicated that SCs play a key role in the hepatoprotection\nprocess by some mechanisms involving anti-inflammation, auto-immune-suppression, angiogenesis\nand anti-apoptosis. Further, studies indicated that SCs derived paracrine factors promote angiogenesis,\nreduce inflammation and inhibit hepatocyte apoptosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The SC-based interventions provide a significant improvement in patients with CLD;\nhowever, there is a need for randomized, controlled studies with the analysis of a long-term follow-up.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867326666191004161802","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T13:19:43Z","timestamp":1570195183000},"page":"6276-6293","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Stem Cell Transplant for Advanced Stage Liver Disorders: Current Scenario and Future Prospects"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-5042","authenticated-orcid":true,"given":"Anjum","family":"Mahmood","sequence":"first","affiliation":[{"name":"GIOSTAR Research Pvt. 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