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Although oxysterols are considered as metabolic intermediates, there is\na growing body of evidence that many of them are bioactive, and their absence or excess may\nbe part of the cause of a disease phenotype. These compounds derive from either enzymatic or\nnon-enzymatic oxidation of cholesterol. This study provides comprehensive information\nabout the structures, formation, and types of oxysterols even when involved in certain disease\nstates, focusing on their effects on metabolism and linkages with these diseases. The role of\nspecific oxysterols as mediators in various disorders, such as degenerative (age-related) and\ncancer-related disorders, has now become clearer. Oxysterol levels may be employed as suitable\nmarkers for the diagnosis of specific diseases or in predicting the incidence rate of diseases,\nsuch as diabetes mellitus, Alzheimer\u2019s disease, multiple sclerosis, osteoporosis, lung\ncancer, breast cancer, and infertility. However, further investigations may be required to confirm\nthese mentioned possibilities.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867327666200316142659","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T14:08:50Z","timestamp":1584367730000},"page":"110-136","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["A Comprehensive Review on Oxysterols and Related Diseases"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-2273","authenticated-orcid":true,"given":"Afshin","family":"Samadi","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-4214","authenticated-orcid":true,"given":"Suna","family":"Sabuncuoglu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8959-3188","authenticated-orcid":true,"given":"Mahshid","family":"Samadi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-2987","authenticated-orcid":true,"given":"Selen Yilmaz","family":"Isikhan","sequence":"additional","affiliation":[{"name":"Vocational Higher School of Social Sciences, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-8307","authenticated-orcid":true,"given":"Salvatore","family":"Chirumbolo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3306-0419","authenticated-orcid":true,"given":"Massimiliano","family":"Peana","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-5746","authenticated-orcid":true,"given":"Incilay","family":"Lay","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-3330","authenticated-orcid":true,"given":"Ahmet","family":"Yalcinkaya","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-3935","authenticated-orcid":true,"given":"Geir","family":"Bj\u00f8rklund","sequence":"additional","affiliation":[{"name":"Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1126\/science.663671","volume":"201","author":"Kandutsch A.A.","year":"1978","unstructured":"Kandutsch A.A.; Chen H.W.; Heiniger H-J.; Biological activity of some oxygenated sterols. 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