{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:21:30Z","timestamp":1747207290441,"version":"3.40.5"},"reference-count":118,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Various nutrients have been designated as antioxidants, with a possible effect on\ndiseases like cancer. This is partly due to their effect on prostaglandins, thereby affecting local\npathological metabolic acidosis. This paper aims to summarize the culprit pathophysiological\nmechanisms involved, with a focus on the bone microenvironment. The omega-\n6\/omega-3 PUFA ratio is particularly investigated for its antioxidative effects, countering\nthese pathways to fight the disease. This feature is looked at concerning its impact on health\nin general, with a particular focus on malignant bone metastasis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867327666200427095331","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T17:03:40Z","timestamp":1588007020000},"page":"1672-1682","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insights into the Effects of Dietary Omega-6\/Omega-3 Polyunsaturated Fatty Acid (PUFA) Ratio on Oxidative Metabolic Pathways of Oncological Bone Disease and Global Health"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-3935","authenticated-orcid":true,"given":"Geir","family":"Bj\u00f8rklund","sequence":"first","affiliation":[{"name":"Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana,Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-801X","authenticated-orcid":true,"given":"Maryam","family":"Dadar","sequence":"additional","affiliation":[{"name":"Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-4615","authenticated-orcid":true,"given":"Monica Daniela","family":"Do\u015fa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Ovidius University, Constanta,Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-8307","authenticated-orcid":true,"given":"Salvatore","family":"Chirumbolo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1572-1997","authenticated-orcid":true,"given":"Joeri J.","family":"Pen","sequence":"additional","affiliation":[{"name":"Diabetes Clinic, Department of Internal Medicine, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels,Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1182\/blood-2004-12-4975","volume":"106","author":"Han S.Y.","year":"2005","unstructured":"Han S.Y.; Lee N.K.; Kim K.H.; Jang I.W.; Yim M.; Kim J.H.; Lee W.J.; Lee S.Y.; Transcriptional induction of cyclooxygenase-2 in osteoclast precursors is involved in RANKL-induced osteoclastogenesis. Blood 2005,106(4),1240-1245","journal-title":"Blood"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1210\/en.2004-1167","volume":"146","author":"Liu X.H.","year":"2005","unstructured":"Liu X.H.; Kirschenbaum A.; Yao S.; Levine A.C.; Cross-talk between the interleukin-6 and prostaglandin E2 signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin\/receptor activator of nuclear factor-{kappa}B (RANK) ligand\/RANK system. Endocrinology 2005,146(4),1991-1998","journal-title":"Endocrinology"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1196\/annals.1346.047","volume":"1068","author":"Liu X.H.","year":"2006","unstructured":"Liu X.H.; Kirschenbaum A.; Yao S.; Levine A.C.; Interactive effect of interleukin-6 and prostaglandin E2 on osteoclastogenesis via the OPG\/RANKL\/RANK system. Ann N Y Acad Sci 2006,1068,225-233","journal-title":"Ann N Y Acad Sci"},{"key":"ref=4","first-page":"201","volume":"66","author":"Chen L.","year":"2011","unstructured":"Chen L.; Zheng T.; Park H.; Noh A.L.; Lee J.M.; Lee D.S.; Yim M.; PDE4 inhibitor suppresses PGE2-induced osteoclast formation via COX-2-mediated p27(KIP1) expression in RAW264.7 cells. Pharmazie 2011,66(3),201-206","journal-title":"Pharmazie"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1016\/j.actbio.2011.05.007","volume":"7","author":"Geng D.","year":"2011","unstructured":"Geng D.; Mao H.; Wang J.; Zhu X.; Huang C.; Chen L.; Yang H.; Xu Y.; Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK\/RANKL. Acta Biomater 2011,7(8),3216-3221","journal-title":"Acta Biomater"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/jbm.a.33197","volume":"99","author":"Geng D.C.","year":"2011","unstructured":"Geng D.C.; Zhu X.S.; Mao H.Q.; Meng B.; Chen L.; Yang H.L.; Xu Y.Z.; Protection against titanium particle-induced osteoclastogenesis by cyclooxygenase-2 selective inhibitor. J Biomed Mater Res A 2011,99(4),516-522","journal-title":"J Biomed Mater Res A"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1254\/jphs.10193SC","volume":"115","author":"Harada S.","year":"2011","unstructured":"Harada S.; Tominari T.; Matsumoto C.; Hirata M.; Takita M.; Inada M.; Miyaura C.; Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NF\u03baB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency. J Pharmacol Sci 2011,115(1),89-93","journal-title":"J Pharmacol Sci"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.phymed.2010.04.003","volume":"18","author":"Hsieh T.P.","year":"2011","unstructured":"Hsieh T.P.; Sheu S.Y.; Sun J.S.; Chen M.H.; Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs\/NF-\u03baB regulated HIF-1\u03b1 and PGE2 synthesis. Phytomedicine 2011,18(2-3),176-185","journal-title":"Phytomedicine"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.biochi.2010.10.001","volume":"93","author":"Zhang F.","year":"2011","unstructured":"Zhang F.; Tanaka H.; Kawato T.; Kitami S.; Nakai K.; Motohashi M.; Suzuki N.; Wang C.L.; Ochiai K.; Isokawa K.; Maeno M.; Interleukin-17A induces cathepsin K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin E2 in osteoblasts. Biochimie 2011,93(2),296-305","journal-title":"Biochimie"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.prostaglandins.2012.01.002","volume":"97","author":"Johansen L.K.","year":"2012","unstructured":"Johansen L.K.; Iburg T.M.; Nielsen O.L.; Leifsson P.S.; Dahl-Petersen K.; Koch J.; Frees D.; Aalb\u00e6k B.; Heegaard P.M.; Jensen H.E.; Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis. Prostaglandins Other Lipid Mediat 2012,97(3-4),103-108","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.archoralbio.2012.07.009","volume":"57","author":"Mayahara K.","year":"2012","unstructured":"Mayahara K.; Yamaguchi A.; Takenouchi H.; Kariya T.; Taguchi H.; Shimizu N.; Osteoblasts stimulate osteoclastogenesis via RANKL expression more strongly than periodontal ligament cells do in response to PGE(2). Arch Oral Biol 2012,57(10),1377-1384","journal-title":"Arch Oral Biol"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/BF02977777","volume":"30","author":"Yoon W.J.","year":"2007","unstructured":"Yoon W.J.; Lee H.J.; Kang G.J.; Kang H.K.; Yoo E.S.; Inhibitory effects of Ficus erecta leaves on osteoporotic factors in vitro. Arch Pharm Res 2007,30(1),43-49","journal-title":"Arch Pharm Res"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1359\/jbmr.1998.13.3.400","volume":"13","author":"Akatsu T.","year":"1998","unstructured":"Akatsu T.; Ono K.; Katayama Y.; Tamura T.; Nishikawa M.; Kugai N.; Yamamoto M.; Nagata N.; The mouse mammary tumor cell line, MMT060562, produces prostaglandin E2 and leukemia inhibitory factor and supports osteoclast formation in vitro via a stromal cell-dependent pathway. J Bone Miner Res 1998,13(3),400-408","journal-title":"J Bone Miner Res"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1359\/jbmr.2002.17.5.774","volume":"17","author":"Ono K.","year":"2002","unstructured":"Ono K.; Akatsu T.; Murakami T.; Kitamura R.; Yamamoto M.; Shinomiya N.; Rokutanda M.; Sasaki T.; Amizuka N.; Ozawa H.; Nagata N.; Kugai N.; Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. J Bone Miner Res 2002,17(5),774-781","journal-title":"J Bone Miner Res"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/S8756-3282(03)00264-3","volume":"33","author":"Ono K.","year":"2003","unstructured":"Ono K.; Akatsu T.; Kugai N.; Pilbeam C.C.; Raisz L.G.; The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines. Bone 2003,33(5),798-804","journal-title":"Bone"},{"key":"ref=16","first-page":"7343","volume":"62","author":"Sabino M.A.","year":"2002","unstructured":"Sabino M.A.; Ghilardi J.R.; Jongen J.L.; Keyser C.P.; Luger N.M.; Mach D.B.; Peters C.M.; Rogers S.D.; Schwei M.J.; de Felipe C.; Mantyh P.W.; Simultaneous reduction in cancer pain, bone destruction and tumor growth by selective inhibition of cyclooxygenase-2. Cancer Res 2002,62(24),7343-7349","journal-title":"Cancer Res"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.febslet.2007.01.005","volume":"581","author":"Takita M.","year":"2007","unstructured":"Takita M.; Inada M.; Maruyama T.; Miyaura C.; Prostaglandin E receptor EP4 antagonist suppresses osteolysis due to bone metastasis of mouse malignant melanoma cells. FEBS Lett 2007,581(3),565-571","journal-title":"FEBS Lett"},{"key":"ref=18","first-page":"466","volume":"18","author":"Inada M.","year":"2008","unstructured":"Inada M.; Miyaura C.; [Role of PGE2 in bone metastatic cancer] Clin Calcium 2008,18(4),466-472","journal-title":"Clin Calcium"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10585-007-9117-3","volume":"25","author":"Li Z.","year":"2008","unstructured":"Li Z.; Schem C.; Shi Y.H.; Medina D.; Zhang M.; Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin Exp Metastasis 2008,25(4),389-400","journal-title":"Clin Exp Metastasis"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1158\/1535-7163.MCT-08-0153","volume":"7","author":"Takahashi T.","year":"2008","unstructured":"Takahashi T.; Uehara H.; Bando Y.; Izumi K.; Soluble EP2 neutralizes prostaglandin E2-induced cell signaling and inhibits osteolytic tumor growth. Mol Cancer Ther 2008,7(9),2807-2816","journal-title":"Mol Cancer Ther"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.2147\/DDDT.S206695","volume":"13","author":"Xiong Z.","year":"2019","unstructured":"Xiong Z.; Luo P.; Zhou J.; Tan M.; 15-Deoxy-\u039412,14-prostaglandin J2 as a potential regulator of bone metabolism via PPAR\u03b3-dependent and independent pathways: a review. Drug Des Devel Ther 2019,13,1879-1888","journal-title":"Drug Des Devel Ther"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbrc.2016.07.075","volume":"478","author":"Watanabe K.","year":"2016","unstructured":"Watanabe K.; Tominari T.; Hirata M.; Matsumoto C.; Maruyama T.; Murphy G.; Nagase H.; Miyaura C.; Inada M.; Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastasis. Biochem Biophys Res Commun 2016,478(1),154-161","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119394","volume":"219","author":"Singh A.V.","year":"2019","unstructured":"Singh A.V.; Dad Ansari M.H.; Dayan C.B.; Giltinan J.; Wang S.; Yu Y.; Kishore V.; Laux P.; Luch A.; Sitti M.; Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery. Biomaterials 2019,219","journal-title":"Biomaterials"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2174\/1573413715666190409101305","volume":"16","author":"Ansari M.H.","year":"2020","unstructured":"Ansari M.H.; Lavhale S.; Kalunke R.M.; Srivastava P.L.; Pandit V.; Gade S.; Yadav S.; Laux P.; Luch A.; Gemmati D.; Recent advances in plant nanobionics and nanobiosensors for toxicology applications. Curr Nanosci 2020,16(1),27-41","journal-title":"Curr Nanosci"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1093\/carcin\/bgp227","volume":"30","author":"Chen Y.C.","year":"2009","unstructured":"Chen Y.C.; Sosnoski D.M.; Gandhi U.H.; Novinger L.J.; Prabhu K.S.; Mastro A.M.; Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. Carcinogenesis 2009,30(11),1941-1948","journal-title":"Carcinogenesis"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.molimm.2019.11.014","volume":"117","author":"Li B.H.","year":"2020","unstructured":"Li B.H.; Garstka M.A.; Li Z.F.; Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor. Mol Immunol 2020,117,201-215","journal-title":"Mol Immunol"},{"key":"ref=27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235841","volume":"20","author":"Irelli A.","year":"2019","unstructured":"Irelli A.; Sirufo M.M.; Scipioni T.; De Pietro F.; Pancotti A.; Ginaldi L.; De Martinis M.; mTOR links tumor immunity and bone metabolism: what are the clinical implications? Int J Mol Sci 2019,20(23)","journal-title":"Int J Mol Sci"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3389\/fphar.2019.01255","volume":"10","author":"Ardura J.A.","year":"2019","unstructured":"Ardura J.A.; Rackov G.; Izquierdo E.; Alonso V.; Gortazar A.R.; Escribese M.M.; Targeting macrophages: friends or foes in disease? Front Pharmacol 2019,10,1255","journal-title":"Front Pharmacol"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.canlet.2011.04.012","volume":"308","author":"Wu J.","year":"2011","unstructured":"Wu J.; Omene C.; Karkoszka J.; Bosland M.; Eckard J.; Klein C.B.; Frenkel K.; Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer. Cancer Lett 2011,308(1),43-53","journal-title":"Cancer Lett"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1158\/1940-6207.CAPR-12-0004-T","volume":"5","author":"Chuu C.P.","year":"2012","unstructured":"Chuu C.P.; Lin H.P.; Ciaccio M.F.; Kokontis J.M.; Hause R.J.; Hiipakka R.A.; Liao S.; Jones R.B.; Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks. Cancer Prev Res (Phila) 2012,5(5),788-797","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/iub.1189","volume":"65","author":"Tolba M.F.","year":"2013","unstructured":"Tolba M.F.; Azab S.S.; Khalifa A.E.; Abdel-Rahman S.Z.; Abdel-Naim A.B.; Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: a review on its anti-inflammatory, neuroprotective, hepatoprotective and cardioprotective effects. IUBMB Life 2013,65(8),699-709","journal-title":"IUBMB Life"},{"key":"ref=32","first-page":"915","volume":"299","author":"Fitzpatrick L.R.","year":"2001","unstructured":"Fitzpatrick L.R.; Wang J.; Le T.; Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J Pharmacol Exp Ther 2001,299(3),915-920","journal-title":"J Pharmacol Exp Ther"},{"key":"ref=33","first-page":"2064","volume":"16","author":"Ozturk G.","year":"2012","unstructured":"Ozturk G.; Ginis Z.; Akyol S.; Erden G.; Gurel A.; Akyol O.; The anticancer mechanism of caffeic acid phenethyl ester (CAPE): review of melanomas, lung and prostate cancers. Eur Rev Med Pharmacol Sci 2012,16(15),2064-2068","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref=34","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071298","volume":"24","author":"Kieliszek M.","year":"2019","unstructured":"Kieliszek M.; Selenium-fascinating microelement, properties and sources in food. Molecules 2019,24(7)","journal-title":"Molecules"},{"key":"ref=35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215318","volume":"20","author":"Pang K.L.","year":"2019","unstructured":"Pang K.L.; Chin K.Y.; Emerging anticancer potentials of selenium on osteosarcoma. Int J Mol Sci 2019,20(21)","journal-title":"Int J Mol Sci"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0736-0266(00)00079-6","volume":"19","author":"Hiraoka K.","year":"2001","unstructured":"Hiraoka K.; Komiya S.; Hamada T.; Zenmyo M.; Inoue A.; Osteosarcoma cell apoptosis induced by selenium. J Orthop Res 2001,19(5),809-814","journal-title":"J Orthop Res"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bbrc.2012.01.005","volume":"418","author":"Moon H.J.","year":"2012","unstructured":"Moon H.J.; Ko W.K.; Han S.W.; Kim D.S.; Hwang Y.S.; Park H.K.; Kwon I.K.; Antioxidants, like coenzyme Q10, selenite and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. Biochem Biophys Res Commun 2012,418(2),247-253","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.2217\/nnm-2017-0024","volume":"12","author":"Maiyo F.","year":"2017","unstructured":"Maiyo F.; Singh M.; Selenium nanoparticles: potential in cancer gene and drug delivery. Nanomedicine (Lond) 2017,12(9),1075-1089","journal-title":"Nanomedicine (Lond)"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.3389\/fphys.2018.01907","volume":"9","author":"Sun J.Y.","year":"2019","unstructured":"Sun J.Y.; Hou Y.J.; Fu X.Y.; Fu X.T.; Ma J.K.; Yang M.F.; Sun B.L.; Fan C.D.; Oh J.; Selenium-containing protein from selenium-enriched Spirulina platensis attenuates cisplatin-induced apoptosis in mc3t3-e1 mouse preosteoblast by inhibiting mitochondrial dysfunction and ros-mediated oxidative damage. Front Physiol 2019,9,1907","journal-title":"Front Physiol"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12011-018-1583-8","volume":"188","author":"Gaffney-Stomberg E.","year":"2019","unstructured":"Gaffney-Stomberg E.; The impact of trace minerals on bone metabolism. Biol Trace Elem Res 2019,188(1),26-34","journal-title":"Biol Trace Elem Res"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0024-3205(97)00030-1","volume":"60","author":"Reiter R.","year":"1997","unstructured":"Reiter R.; Tang L.; Garcia J.J.; Mu\u00f1oz-Hoyos A.; Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997,60(25),2255-2271","journal-title":"Life Sci"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/j.1749-6632.1999.tb08028.x","volume":"890","author":"Reiter R.J.","year":"1999","unstructured":"Reiter R.J.; Cabrera J.; Sainz R.M.; Mayo J.C.; Manchester L.C.; Tan D.X.; Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington\u2019s disease, Alzheimer\u2019s disease and parkinsonism. Ann N Y Acad Sci 1999,890,471-485","journal-title":"Ann N Y Acad Sci"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1749-6632.2001.tb03627.x","volume":"939","author":"Reiter R.J.","year":"2001","unstructured":"Reiter R.J.; Acu\u00f1a-Castroviejo D.; Tan D.X.; Burkhardt S.; Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci 2001,939,200-215","journal-title":"Ann N Y Acad Sci"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0301-0082(98)00052-5","volume":"56","author":"Reiter R.J.","year":"1998","unstructured":"Reiter R.J.; Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 1998,56(3),359-384","journal-title":"Prog Neurobiol"},{"key":"ref=45","first-page":"135","volume":"12","author":"Reiter R.J.","year":"1998","unstructured":"Reiter R.J.; Garcia J.J.; Pie J.; Oxidative toxicity in models of neurodegeneration: responses to melatonin. Restor Neurol Neurosci 1998,12(2-3),135-142","journal-title":"Restor Neurol Neurosci"},{"key":"ref=46","first-page":"575","volume":"19","author":"Reiter R.J.","year":"1998","unstructured":"Reiter R.J.; Tan D.X.; Qi W.B.; Suppression of oxygen toxicity by melatonin. Zhongguo Yao Li Xue Bao 1998,19(6),575-581","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"ref=47","first-page":"668","volume":"40","author":"Srinivasan V.","year":"2002","unstructured":"Srinivasan V.; Melatonin oxidative stress and neurodegenerative diseases. Indian J Exp Biol 2002,40(6),668-679","journal-title":"Indian J Exp Biol"},{"key":"ref=48","first-page":"373","volume":"47","author":"Gupta Y.K.","year":"2003","unstructured":"Gupta Y.K.; Gupta M.; Kohli K.; Neuroprotective role of melatonin in oxidative stress vulnerable brain. Indian J Physiol Pharmacol 2003,47(4),373-386","journal-title":"Indian J Physiol Pharmacol"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1600-079X.2005.00225.x","volume":"39","author":"Esparza J.L.","year":"2005","unstructured":"Esparza J.L.; G\u00f3mez M.; Rosa Nogu\u00e9s M.; Paternain J.L.; Mallol J.; Domingo J.L.; Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats. J Pineal Res 2005,39(2),129-136","journal-title":"J Pineal Res"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1600-079X.2007.00514.x","volume":"44","author":"Hung M.W.","year":"2008","unstructured":"Hung M.W.; Tipoe G.L.; Poon A.M.; Reiter R.J.; Fung M.L.; Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. J Pineal Res 2008,44(2),214-221","journal-title":"J Pineal Res"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"287","DOI":"10.2174\/187152410793429683","volume":"10","author":"Lim\u00f3n-Pacheco J.H.","year":"2010","unstructured":"Lim\u00f3n-Pacheco J.H.; Gonsebatt M.E.; The glutathione system and its regulation by neurohormone melatonin in the central nervous system. Cent Nerv Syst Agents Med Chem 2010,10(4),287-297","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/jpi.12018","volume":"54","author":"Fischer T.W.","year":"2013","unstructured":"Fischer T.W.; Kleszczy\u0144ski K.; Hardkop L.H.; Kruse N.; Zillikens D.; Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion and protects against the formation of DNA damage (8-hydroxy-2\u2032-deoxyguanosine) in ex vivo human skin. J Pineal Res 2013,54(3),303-312","journal-title":"J Pineal Res"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/jpi.12069","volume":"55","author":"Wang F.","year":"2013","unstructured":"Wang F.; Tian X.; Zhang L.; Tan D.; Reiter R.J.; Liu G.; Melatonin promotes the in vitro development of pronuclear embryos and increases the efficiency of blastocyst implantation in murine. J Pineal Res 2013,55(3),267-274","journal-title":"J Pineal Res"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/jpi.12070","volume":"55","author":"Yang Y.","year":"2013","unstructured":"Yang Y.; Duan W.; Jin Z.; Yi W.; Yan J.; Zhang S.; Wang N.; Liang Z.; Li Y.; Chen W.; Yi D.; Yu S.; JAK2\/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia\/reperfusion injury. J Pineal Res 2013,55(3),275-286","journal-title":"J Pineal Res"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.freeradbiomed.2004.10.009","volume":"38","author":"G\u00f3mez M.","year":"2005","unstructured":"G\u00f3mez M.; Esparza J.L.; Nogu\u00e9s M.R.; Giralt M.; Cabr\u00e9 M.; Domingo J.L.; Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration. Free Radic Biol Med 2005,38(1),104-111","journal-title":"Free Radic Biol Med"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1007\/s00726-011-0962-7","volume":"42","author":"Jong C.J.","year":"2012","unstructured":"Jong C.J.; Azuma J.; Schaffer S.; Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 2012,42(6),2223-2232","journal-title":"Amino Acids"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00774-006-0734-8","volume":"25","author":"Nagae M.","year":"2007","unstructured":"Nagae M.; Hiraga T.; Yoneda T.; Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization. J Bone Miner Metab 2007,25(2),99-104","journal-title":"J Bone Miner Metab"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0952-3278(03)00060-7","volume":"68","author":"Fernandes G.","year":"2003","unstructured":"Fernandes G.; Lawrence R.; Sun D.; Protective role of n-3 lipids and soy protein in osteoporosis. Prostaglandins Leukot Essent Fatty Acids 2003,68(6),361-372","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1096\/fasebj.6.8.1592205","volume":"6","author":"Lands W.E.","year":"1992","unstructured":"Lands W.E.; Biochemistry and physiology of n-3 fatty acids. FASEB J 1992,6(8),2530-2536","journal-title":"FASEB J"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0952-3278(99)80023-4","volume":"60","author":"Simopoulos A.P.","year":"1999","unstructured":"Simopoulos A.P.; Evolutionary aspects of omega-3 fatty acids in the food supply. Prostaglandins Leukot Essent Fatty Acids 1999,60(5-6),421-429","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1038\/sj.ejcn.1601353","volume":"56","author":"Cordain L.","year":"2002","unstructured":"Cordain L.; Eaton S.B.; Miller J.B.; Mann N.; Hill K.; The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic. Eur J Clin Nutr 2002,56(Suppl. 1),S42-S52","journal-title":"Eur J Clin Nutr"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1158\/0008-5472.CAN-05-4063","volume":"66","author":"Daikoku T.","year":"2006","unstructured":"Daikoku T.; Tranguch S.; Trofimova I.N.; Dinulescu D.M.; Jacks T.; Nikitin A.Y.; Connolly D.C.; Dey S.K.; Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res 2006,66(5),2527-2531","journal-title":"Cancer Res"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1359\/jbmr.2003.18.7.1317","volume":"18","author":"Frick K.K.","year":"2003","unstructured":"Frick K.K.; Bushinsky D.A.; Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism. J Bone Miner Res 2003,18(7),1317-1325","journal-title":"J Bone Miner Res"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1046\/j.1525-139X.2003.16100.x","volume":"16","author":"Krieger N.S.","year":"2003","unstructured":"Krieger N.S.; Bushinsky D.A.; Frick K.K.; Cellular mechanisms of bone resorption induced by metabolic acidosis. Semin Dial 2003,16(6),463-466","journal-title":"Semin Dial"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1359\/jbmr.070316","volume":"22","author":"Krieger N.S.","year":"2007","unstructured":"Krieger N.S.; Frick K.K.; LaPlante Strutz K.; Michalenka A.; Bushinsky D.A.; Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro. J Bone Miner Res 2007,22(6),907-917","journal-title":"J Bone Miner Res"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1359\/jbmr.080236","volume":"23","author":"Tomura H.","year":"2008","unstructured":"Tomura H.; Wang J.Q.; Liu J.P.; Komachi M.; Damirin A.; Mogi C.; Tobo M.; Nochi H.; Tamoto K.; Im, D.S.; Sato, K.; Okajima, F. Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line. J Bone Miner Res 2008,23(7),1129-1139","journal-title":"J Bone Miner Res"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1158\/0008-5472.CAN-12-3970","volume":"73","author":"Liu Q.","year":"2013","unstructured":"Liu Q.; Russell M.R.; Shahriari K.; Jernigan D.L.; Lioni M.I.; Garcia F.U.; Fatatis A.; Interleukin-1\u03b2 promotes skeletal colonization and progression of metastatic prostate cancer cells with neuroendocrine features. Cancer Res 2013,73(11),3297-3305","journal-title":"Cancer Res"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00424-002-0989-4","volume":"445","author":"Kajiya H.","year":"2003","unstructured":"Kajiya H.; Okamoto F.; Fukushima H.; Okabe K.; Calcitonin inhibits proton extrusion in resorbing rat osteoclasts via protein kinase A. Pflugers Arch 2003,445(6),651-658","journal-title":"Pflugers Arch"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/1471-2474-11-250","volume":"11","author":"S\u00f8rensen M.G.","year":"2010","unstructured":"S\u00f8rensen M.G.; Karsdal M.A.; Dziegiel M.H.; Boutin J.A.; Nosjean O.; Henriksen K.; Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption. BMC Musculoskelet Disord 2010,11,250","journal-title":"BMC Musculoskelet Disord"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2174\/138920312800493133","volume":"13","author":"Thudium C.S.","year":"2012","unstructured":"Thudium C.S.; Jensen V.K.; Karsdal M.A.; Henriksen K.; Disruption of the V-ATPase functionality as a way to uncouple bone formation and resorption - a novel target for treatment of osteoporosis. Curr Protein Pept Sci 2012,13(2),141-151","journal-title":"Curr Protein Pept Sci"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"779","DOI":"10.2217\/14796694.1.6.779","volume":"1","author":"De Milito A.","year":"2005","unstructured":"De Milito A.; Fais S.; Tumor acidity, chemoresistance and proton pump inhibitors. Future Oncol 2005,1(6),779-786","journal-title":"Future Oncol"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"192","DOI":"10.2174\/156720109787846225","volume":"6","author":"Sheraly A.R.","year":"2009","unstructured":"Sheraly A.R.; Lickorish D.; Sarraf F.; Davies J.E.; Use of gastrointestinal proton pump inhibitors to regulate osteoclast-mediated resorption of calcium phosphate cements in vivo. Curr Drug Deliv 2009,6(2),192-198","journal-title":"Curr Drug Deliv"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1479-5876-8-57","volume":"8","author":"Huber V.","year":"2010","unstructured":"Huber V.; De Milito A.; Harguindey S.; Reshkin S.J.; Wahl M.L.; Rauch C.; Chiesi A.; Pouyss\u00e9gur J.; Gatenby R.A.; Rivoltini L.; Fais S.; Proton dynamics in cancer. J Transl Med 2010,8,57","journal-title":"J Transl Med"},{"key":"ref=74","first-page":"264","volume":"15","author":"McCarty M.F.","year":"2010","unstructured":"McCarty M.F.; Whitaker J.; Manipulating tumor acidification as a cancer treatment strategy. Altern Med Rev 2010,15(3),264-272","journal-title":"Altern Med Rev"},{"key":"ref=75","first-page":"79","volume":"34","author":"Calorini L.","year":"2012","unstructured":"Calorini L.; Peppicelli S.; Bianchini F.; Extracellular acidity as favouring factor of tumor progression and metastatic dissemination. Exp Oncol 2012,34(2),79-84","journal-title":"Exp Oncol"},{"key":"ref=76","first-page":"3847","volume":"63","author":"Gatenby R.A.","year":"2003","unstructured":"Gatenby R.A.; Gawlinski E.T.; The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res 2003,63(14),3847-3854","journal-title":"Cancer Res"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s10585-011-9415-7","volume":"28","author":"Ibrahim Hashim A.","year":"2011","unstructured":"Ibrahim Hashim A.; Cornnell H.H.; Coelho Ribeiro, Mde.L.; Abrahams, D.; Cunningham, J.; Lloyd, M.; Martinez, G.V.; Gatenby, R.A.; Gillies, R.J. Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis 2011,28(8),841-849","journal-title":"Clin Exp Metastasis"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1158\/0008-5472.CAN-05-4193","volume":"66","author":"Gatenby R.A.","year":"2006","unstructured":"Gatenby R.A.; Gawlinski E.T.; Gmitro A.F.; Kaylor B.; Gillies R.J.; Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 2006,66(10),5216-5223","journal-title":"Cancer Res"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1158\/0008-5472.CAN-07-5575","volume":"69","author":"Robey I.F.","year":"2009","unstructured":"Robey I.F.; Baggett B.K.; Kirkpatrick N.D.; Roe D.J.; Dosescu J.; Sloane B.F.; Hashim A.I.; Morse D.L.; Raghunand N.; Gatenby R.A.; Gillies R.J.; Bicarbonate increases tumor pH and inhibits spontaneous metastasis. Cancer Res 2009,69(6),2260-2268","journal-title":"Cancer Res"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1158\/0008-5472.CAN-12-2796","volume":"73","author":"Estrella V.","year":"2013","unstructured":"Estrella V.; Chen T.; Lloyd M.; Wojtkowiak J.; Cornnell H.H.; Ibrahim-Hashim A.; Bailey K.; Balagurunathan Y.; Rothberg J.M.; Sloane B.F.; Johnson J.; Gatenby R.A.; Gillies R.J.; Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 2013,73(5),1524-1535","journal-title":"Cancer Res"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/01.mnh.0000133975.32559.6b","volume":"13","author":"Krieger N.S.","year":"2004","unstructured":"Krieger N.S.; Frick K.K.; Bushinsky D.A.; Mechanism of acid-induced bone resorption. Curr Opin Nephrol Hypertens 2004,13(4),423-436","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"415S","DOI":"10.1093\/jn\/138.2.415S","volume":"138","author":"Arnett T.R.","year":"2008","unstructured":"Arnett T.R.; Extracellular pH regulates bone cell function. J Nutr 2008,138(2),415S-418S","journal-title":"J Nutr"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bone.2007.08.044","volume":"42","author":"Pereverzev A.","year":"2008","unstructured":"Pereverzev A.; Komarova S.V.; Korcok J.; Armstrong S.; Tremblay G.B.; Dixon S.J.; Sims S.M.; Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway. Bone 2008,42(1),150-161","journal-title":"Bone"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/jcp.21767","volume":"220","author":"Geng W.","year":"2009","unstructured":"Geng W.; Hill K.; Zerwekh J.E.; Kohler T.; M\u00fcller R.; Moe O.W.; Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol 2009,220(2),332-340","journal-title":"J Cell Physiol"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.abb.2010.07.021","volume":"503","author":"Arnett T.R.","year":"2010","unstructured":"Arnett T.R.; Acidosis, hypoxia and bone. Arch Biochem Biophys 2010,503(1),103-109","journal-title":"Arch Biochem Biophys"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ejphar.2011.04.062","volume":"663","author":"Kato K.","year":"2011","unstructured":"Kato K.; Morita I.; Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: a study to elucidate the action points of acidosis and search for putative target molecules. Eur J Pharmacol 2011,663(1-3),27-39","journal-title":"Eur J Pharmacol"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.bbrc.2011.12.149","volume":"418","author":"Ahn H.","year":"2012","unstructured":"Ahn H.; Kim J.M.; Lee K.; Kim H.; Jeong D.; Extracellular acidosis accelerates bone resorption by enhancing osteoclast survival, adhesion and migration. Biochem Biophys Res Commun 2012,418(1),144-148","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"33","DOI":"10.5582\/bst.2013.v7.1.33","volume":"7","author":"Kato K.","year":"2013","unstructured":"Kato K.; Morita I.; Promotion of osteoclast differentiation and activation in spite of impeded osteoblast-lineage differentiation under acidosis: effects of acidosis on bone metabolism. Biosci Trends 2013,7(1),33-41","journal-title":"Biosci Trends"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1002\/jbmr.2003","volume":"28","author":"Kogawa M.","year":"2013","unstructured":"Kogawa M.; Wijenayaka A.R.; Ormsby R.T.; Thomas G.P.; Anderson P.H.; Bonewald L.F.; Findlay D.M.; Atkins G.J.; Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2. J Bone Miner Res 2013,28(12),2436-2448","journal-title":"J Bone Miner Res"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00223-004-0285-8","volume":"77","author":"Brandao-Burch A.","year":"2005","unstructured":"Brandao-Burch A.; Utting J.C.; Orriss I.R.; Arnett T.R.; Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralization. Calcif Tissue Int 2005,77(3),167-174","journal-title":"Calcif Tissue Int"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00223-013-9746-2","volume":"93","author":"Takeuchi S.","year":"2013","unstructured":"Takeuchi S.; Hirukawa K.; Togari A.; Acidosis inhibits mineralization in human osteoblasts. Calcif Tissue Int 2013,93(3),233-240","journal-title":"Calcif Tissue Int"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00424-005-1457-8","volume":"451","author":"Tominaga M.","year":"2005","unstructured":"Tominaga M.; Tominaga T.; Structure and function of TRPV1. Pflugers Arch 2005,451(1),143-150","journal-title":"Pflugers Arch"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/01.anes.0000264777.94662.d6","volume":"106","author":"O\u2019Rielly D.D.","year":"2007","unstructured":"O\u2019Rielly D.D.; Loomis C.W.; Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation. Anesthesiology 2007,106(4),795-805","journal-title":"Anesthesiology"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/00002371-200003000-00004","volume":"23","author":"Fischer B.","year":"2000","unstructured":"Fischer B.; M\u00fcller B.; Fisch P.; Kreutz W.; An acidic microenvironment inhibits antitumoral non-major histocompatibility complex-restricted cytotoxicity: implications for cancer immunotherapy. J Immunother 2000,23(2),196-207","journal-title":"J Immunother"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1006\/clim.2000.4904","volume":"96","author":"Fischer B.","year":"2000","unstructured":"Fischer B.; M\u00fcller B.; Fischer K.G.; Baur N.; Kreutz W.; Acidic pH inhibits non-MHC-restricted killer cell functions. Clin Immunol 2000,96(3),252-263","journal-title":"Clin Immunol"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1046\/j.1365-2567.2000.00975.x","volume":"99","author":"M\u00fcller B.","year":"2000","unstructured":"M\u00fcller B.; Fischer B.; Kreutz W.; An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells. Immunology 2000,99(3),375-384","journal-title":"Immunology"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000217905","volume":"15","author":"Severin T.","year":"1994","unstructured":"Severin T.; M\u00fcller B.; Giese G.; Uhl B.; Wolf B.; Hauschildt S.; Kreutz W.; pH-dependent LAK cell cytotoxicity. Tumour Biol 1994,15(5),304-310","journal-title":"Tumour Biol"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fphar.2014.00196","volume":"5","author":"Aquilano K.","year":"2014","unstructured":"Aquilano K.; Baldelli S.; Ciriolo M.R.; Glutathione: new roles in redox signaling for an old antioxidant. Front Pharmacol 2014,5,196","journal-title":"Front Pharmacol"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10456-015-9471-8","volume":"18","author":"d\u2019Audigier C.","year":"2015","unstructured":"d\u2019Audigier C.; Cochain C.; Rossi E.; Gu\u00e9rin C.L.; Bi\u00e8che I.; Blandini\u00e8res A.; Marsac B.; Silvestre J.S.; Gaussem P.; Smadja D.M.; Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism. Angiogenesis 2015,18(3),347-359","journal-title":"Angiogenesis"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/eurheartj\/ehw550","volume":"38","author":"Koupenova M.","year":"2017","unstructured":"Koupenova M.; Kehrel B.E.; Corkrey H.A.; Freedman J.E.; Thrombosis and platelets: an update. Eur Heart J 2017,38(11),785-791","journal-title":"Eur Heart J"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000235706","volume":"100","author":"Simopoulos A.P.","year":"2009","unstructured":"Simopoulos A.P.; Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. World Rev Nutr Diet 2009,100,1-21","journal-title":"World Rev Nutr Diet"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1017\/S0007114516000349","volume":"115","author":"\u015arednicka-Tober D.","year":"2016","unstructured":"\u015arednicka-Tober D.; Bara\u0144ski M.; Seal C.J.; Sanderson R.; Benbrook C.; Steinshamn H.; Gromadzka-Ostrowska J.; Rembia\u0142kowska E.; Skwar\u0142o-So\u0144ta K.; Eyre M.; Cozzi G.; Larsen M.K.; Jordon T.; Niggli U.; Sakowski T.; Calder P.C.; Burdge G.C.; Sotiraki S.; Stefanakis A.; Stergiadis S.; Yolcu H.; Chatzidimitriou E.; Butler G.; Stewart G.; Leifert C.; Higher PUFA and n-3 PUFA, conjugated linoleic acid, \u03b1-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- and redundancy analyses. Br J Nutr 2016,115(6),1043-1060","journal-title":"Br J Nutr"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1007\/s00394-016-1226-9","volume":"56","author":"Stevenson J.L.","year":"2017","unstructured":"Stevenson J.L.; Miller M.K.; Skillman H.E.; Paton C.M.; Cooper J.A.; A PUFA-rich diet improves fat oxidation following saturated fat-rich meal. Eur J Nutr 2017,56(5),1845-1857","journal-title":"Eur J Nutr"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s10865-014-9608-z","volume":"38","author":"Burns J.W.","year":"2015","unstructured":"Burns J.W.; Quartana P.J.; Bruehl S.; Janssen I.; Dugan S.A.; Appelhans B.; Matthews K.A.; Kravitz H.M.; Chronic pain, body mass index and cardiovascular disease risk factors: tests of moderation, unique and shared relationships in the Study of Women\u2019s Health Across the Nation (SWAN). J Behav Med 2015,38(2),372-383","journal-title":"J Behav Med"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10911-015-9333-4","volume":"20","author":"Hugo H.J.","year":"2015","unstructured":"Hugo H.J.; Saunders C.; Ramsay R.G.; Thompson E.W.; New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis. J Mammary Gland Biol Neoplasia 2015,20(3-4),109-119","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.ejmech.2015.12.036","volume":"109","author":"Migliore M.","year":"2016","unstructured":"Migliore M.; Habrant D.; Sasso O.; Albani C.; Bertozzi S.M.; Armirotti A.; Piomelli D.; Scarpelli R.; Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. Eur J Med Chem 2016,109,216-237","journal-title":"Eur J Med Chem"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/030089161309900101","volume":"99","author":"Ibrahim T.","year":"2013","unstructured":"Ibrahim T.; Farolfi A.; Mercatali L.; Ricci M.; Amadori D.; Metastatic bone disease in the era of bone-targeted therapy: clinical impact. Tumori 2013,99(1),1-9","journal-title":"Tumori"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1159\/000082923","volume":"67","author":"Delea T.","year":"2004","unstructured":"Delea T.; Langer C.; McKiernan J.; Liss M.; Edelsberg J.; Brandman J.; Sung J.; Raut M.; Oster G.; The cost of treatment of skeletal-related events in patients with bone metastasis from lung cancer. Oncology 2004,67(5-6),390-396","journal-title":"Oncology"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.2147\/IJN.S197499","volume":"14","author":"Serini S.","year":"2019","unstructured":"Serini S.; Cassano R.; Trombino S.; Calviello G.; Nanomedicine-based formulations containing \u03c9-3 polyunsaturated fatty acids: potential application in cardiovascular and neoplastic diseases. Int J Nanomedicine 2019,14,2809-2828","journal-title":"Int J Nanomedicine"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15761\/IFNM.1000237","volume":"5","author":"Dwivedi C.","year":"2018","unstructured":"Dwivedi C.; Pandey I.; Misra V.; Giulbudagian M.; Jungnickel H.; Laux P.; Luch A.; Ramteke P.W.; Singh A.V.; The prospective role of nanobiotechnology in food and food packaging products. Integr Food Nutr Metab 2018,5(6),1-5","journal-title":"Integr Food Nutr Metab"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1080\/15376516.2019.1566425","volume":"29","author":"Singh A.V.","year":"2019","unstructured":"Singh A.V.; Laux P.; Luch A.; Sudrik C.; Wiehr S.; Wild A-M.; Santomauro G.; Bill J.; Sitti M.; Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design. Toxicol Mech Methods 2019,29(5),378-387","journal-title":"Toxicol Mech Methods"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2010.10.063","volume":"402","author":"Mandal C.C.","year":"2010","unstructured":"Mandal C.C.; Ghosh-Choudhury T.; Yoneda T.; Choudhury G.G.; Ghosh-Choudhury N.; Fish oil prevents breast cancer cell metastasis to bone. Biochem Biophys Res Commun 2010,402(4),602-607","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10549-013-2703-y","volume":"141","author":"Rahman M.M.","year":"2013","unstructured":"Rahman M.M.; Veigas J.M.; Williams P.J.; Fernandes G.; DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. Breast Cancer Res Treat 2013,141(3),341-352","journal-title":"Breast Cancer Res Treat"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"542","DOI":"10.2174\/1871520616666160817143656","volume":"17","author":"Zu Y.","year":"2017","unstructured":"Zu Y.; Hu Y.; Yu X.; Jiang S.; Docetaxel-loaded bovine serum albumin nanoparticles conjugated docosahexaenoic acid for inhibiting lung cancer metastasis to bone. Anticancer Agents Med Chem 2017,17(4),542-551","journal-title":"Anticancer Agents Med Chem"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3390\/nu11050945","volume":"11","author":"Freitas R.D.S.","year":"2019","unstructured":"Freitas R.D.S.; Campos M.M.; Protective effects of omega-3 fatty acids in cancer-related complications. Nutrients 2019,11(5),945","journal-title":"Nutrients"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.2174\/0929867325666180629123817","volume":"26","author":"Bj\u00f8rklund G.","year":"2019","unstructured":"Bj\u00f8rklund G.; Dadar M.; Aaseth J.; Chirumbolo S.; Pen J.J.; Cancer-associated cachexia, reactive oxygen species and nutrition therapy. Curr Med Chem 2019,26(31),5728-5744","journal-title":"Curr Med Chem"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.clnu.2018.07.009","volume":"38","author":"Berger M.M.","year":"2019","unstructured":"Berger M.M.; Reintam-Blaser A.; Calder P.C.; Casaer M.; Hiesmayr M.J.; Mayer K.; Montejo J.C.; Pichard C.; Preiser J.C.; van Zanten A.R.H.; Bischoff S.C.; Singer P.; Monitoring nutrition in the ICU. Clin Nutr 2019,38(2),584-593","journal-title":"Clin Nutr"},{"key":"ref=118","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080798","volume":"2019","author":"Tamarindo G.H.","year":"2019","unstructured":"Tamarindo G.H.; Ribeiro D.L.; Gobbo M.G.; Guerra L.H.; Rahal P.; Taboga S.R.; Gadelha F.R.; G\u00f3es R.M.; Melatonin and docosahexaenoic acid decrease proliferation of PNT1A prostate benign cells via modulation of mitochondrial bioenergetics and ROS production. Oxid Med Cell Longev 2019,2019","journal-title":"Oxid Med Cell Longev"}],"container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929867327666200427095331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/181367\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929867327666200427095331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T18:35:15Z","timestamp":1660070115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/181367\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":118,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867327666200427095331","relation":{},"ISSN":["0929-8673"],"issn-type":[{"type":"print","value":"0929-8673"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}