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Curcumin is the polyphenolic phytochemical component of the spice turmeric with a wide range of pharmacological activities. It acts in several ways as a modulator of DCs and converts them into tolerogenic DCs. Tolerogenic DCs possess anti-inflammatory and immunomodulatory activities that regulate the immune responses in health and disease. Curcumin by blocking maturation markers, cytokines and chemokines expression, and disrupting the antigen-presenting machinery of DCs render them non- or hypo-responsive to immunostimulants. It also reduces the expression of co-stimulatory and adhesion molecules on DCs and prevents them from both migration and antigen presentation but enhances their endocytosis capacity. Hence, curcumin causes DCs-inducing regulatory T cells and dampens CD4+ T helper 1 (Th1), Th2, and Th17 polarization. Inhibition of transcription factors such as NF-\u03baB, AP-1, MAPKs (p38, JNK, ERK) and other intracellular signaling molecules such as JAK\/STAT\/SOCS provide a plausible explanation for most of these observations. In this review, we summarize the potential effects of curcumin on the phenotypes and functions of DCs as the key players in orchestration, stimulation, and modulation of the immune responses.<\/jats:p><\/jats:sec>","DOI":"10.2174\/0929867327666200515101228","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:13:50Z","timestamp":1589537630000},"page":"1549-1564","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells"],"prefix":"10.2174","volume":"28","author":[{"given":"Kaveh","family":"Rahimi","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Hassanzadeh","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashem","family":"Khanbabaei","sequence":"additional","affiliation":[{"name":"Medical Physics Department, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed M.","family":"Haftcheshmeh","sequence":"additional","affiliation":[{"name":"Department of Medical Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 91766-99199,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmael","family":"Izadpanah","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asadollah","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Halal Research Center of IRI, FDA, Tehran,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.4049\/jimmunol.1701024","volume":"200","author":"Santos PM","year":"2018","unstructured":"Santos PM; Butterfield LH; Dendritic cell-based cancer vaccines. 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