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In addition, the administration of drugs\nthrough the skin avoids the first-pass metabolism, allowing an increase in the bioavailability\nof drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises\nthe main barrier of protection against external agents, mainly due to its structure, composition\nand physicochemical properties, becoming the main limitation for the administration of substances\nthrough the skin. In view of the above, pharmaceutical technology has allowed the\ndevelopment of multiple drug delivery systems (DDS), which include liquid crystals (LC),\ncubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins\n(CD) and dendrimers (DND). It appears that the DDS circumvents the problems\nof drug absorption through the SC layer of the skin, ensuring the release of the drug, as well\nas optimizing the therapeutic effect locally. This review aims to highlight the DDS that include\nLC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin\ntherapies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867327666200831125656","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T09:41:26Z","timestamp":1598953286000},"page":"3216-3248","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-5245","authenticated-orcid":true,"given":"Franciele Garcia","family":"Baveloni","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Department of Drugs and Medicines, Sao Paulo State University, Rodovia Araraquara-Jau, km 01, Araraquara, SP, CEP 14800-903,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-0662","authenticated-orcid":true,"given":"Bruno Vincenzo Fiod","family":"Riccio","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Department of Drugs and Medicines, Sao Paulo State University, Rodovia Araraquara-Jau, km 01, Araraquara, SP, CEP 14800-903,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-8756","authenticated-orcid":true,"given":"Leonardo Delello","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Department of Drugs and Medicines, Sao Paulo State University, Rodovia Araraquara-Jau, km 01, Araraquara, SP, CEP 14800-903,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0412-6439","authenticated-orcid":true,"given":"Mariza Aires","family":"Fernandes","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Department of Drugs and Medicines, Sao Paulo State University, Rodovia Araraquara-Jau, km 01, Araraquara, SP, CEP 14800-903,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-2819","authenticated-orcid":true,"given":"Andr\u00e9ia Bagliotti","family":"Meneguin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Department of Drugs and Medicines, Sao Paulo State University, Rodovia Araraquara-Jau, km 01, Araraquara, SP, CEP 14800-903,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-0545","authenticated-orcid":true,"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Department of Drugs and Medicines, Sao Paulo State University, Rodovia Araraquara-Jau, km 01, Araraquara, SP, CEP 14800-903,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"494","author":"Barry B.W.","year":"1983","unstructured":"Barry B.W.;  Dermatological Formulations: Percutaneous Absorption 1983,494","journal-title":"Dermatological Formulations: Percutaneous Absorption"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.mpmed.2017.03.004","volume":"45","author":"Lai-Cheong J.E.","year":"2017","unstructured":"Lai-Cheong J.E.; McGrath J.A.; Structure and function of skin, hair and nails. 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