{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:21:38Z","timestamp":1747207298334,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"22","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>COVID-19 is an emerging outbreak similar to previous pandemics caused by Severe\nAcute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS).\nTill date, SARS-CoV-2 infection is still spreading, representing a major threat to public\nhealth, where several control measures are being practiced in order to culminate its spread.\nThe research and development of new drugs require a lot of funding in addition to being a\nslow and costly process. As a result, new techniques have been proposed to streamline this\nprocess. The repositioning or repurposing of drugs represents an attractive strategy, presenting\na promising way to introduce new drugs. Currently, numerous reused drugs are already available\nin the market and are in practice. In this review, it was observed that the antiviral drugs\nEntricitabine and Tenofovir display potential therapeutic efficacy in preclinical studies.\nTherefore, in silico analyses were considered a potential tool for predicting the effectiveness\nof drugs, mainly as an effective approach to encourage a complementary in vitro and in vivo\nantiviral evaluation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867327666201005113204","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T05:41:49Z","timestamp":1601962909000},"page":"4577-4585","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-0098","authenticated-orcid":true,"given":"Yasmim Mendes","family":"Rocha","sequence":"first","affiliation":[{"name":"Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Ceara (UFC), Fortaleza- CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-6951","authenticated-orcid":true,"given":"Gabriel Ac\u00e1cio","family":"de Moura","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Ceara (UECE), Fortaleza-CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-9357","authenticated-orcid":true,"given":"Juliana Ramos","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia (Renorbio), Universidade Estadual do Ceara (UECE), Fortaleza-CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-6462","authenticated-orcid":true,"given":"Larissa Deadame","family":"de Figueiredo Nicolete","sequence":"additional","affiliation":[{"name":"International University for the Integration of Afro-Brazilian Lusophony (UNILAB), Redencao-CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-3975","authenticated-orcid":true,"given":"Roberto","family":"Nicolete","sequence":"additional","affiliation":[{"name":"Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Ceara (UFC), Fortaleza- CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186587\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T10:04:58Z","timestamp":1628071498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186587\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":0,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,8,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867327666201005113204","relation":{},"ISSN":["0929-8673"],"issn-type":[{"type":"print","value":"0929-8673"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}