{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:14:29Z","timestamp":1789157669204,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"35","funder":[{"DOI":"10.13039\/501100009873","name":"RAS Regione Autonoma Sardegna-\u201cMetallo-farmaci innovativi: biotrasformazione e target biologici. Un approccio integrato\u201d","doi-asserted-by":"publisher","award":["RASSR79857"],"award-info":[{"award-number":["RASSR79857"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Although most of the harmful radionuclides are of anthropogenic origin and released\nfrom military or industrial processes, radioactive substances, such as uranium, also\noccur naturally in the environment. Low standards of care at nuclear facilities can lead\nto the contamination of employees with radionuclides due to inhalation of gases or dust\nor contamination of skin or wounds. Various sources for radionuclide exposure may present\nconcerns for radioactive polonium or plutonium exposure, for instance, terrorist actions\non the infrastructure, such as on drinking water basins. Early health effects after extensive\nradiation exposure may be vomiting, headaches, and fatigue, followed by bone\nmarrow depression, fever, and diarrhea. The main purpose of radionuclide mobilization\nis to minimize the radiation dose. Since some of the important radionuclides, such as\npolonium and plutonium, have very long biological half-times after their deposition in\nbone, liver or kidneys, rapid initiation of chelation treatment is usually imperative after a\ncontamination event. The antidote DMPS (dimercapto-propanesulfonate) is considered\nthe drug of choice for polonium decorporation. DTPA (diethylenetriamine pentaacetate)\nis a potent chelator especially approved for radionuclide mobilization, including polonium\nand other actinides. Other chelators and drugs are under investigation as potential chelators\nof transuranic elements.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867327666201020152253","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T07:30:41Z","timestamp":1603265441000},"page":"7238-7246","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Therapy of Patients Contaminated with Polonium or Plutonium"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-5703","authenticated-orcid":true,"given":"Jan","family":"Aaseth","sequence":"first","affiliation":[{"name":"Research Department, Innlandet Hospital Trust, 2381 Brumunddal,Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-1988","authenticated-orcid":true,"given":"Valeria Marina","family":"Nurchi","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Cittadella Universitaria, 09042 Monserrato,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-6060","authenticated-orcid":true,"given":"Ole","family":"Andersen","sequence":"additional","affiliation":[{"name":"Roskilde University, 4000 Roskilde,Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929867327666201020152253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/187036\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929867327666201020152253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T11:32:30Z","timestamp":1669807950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/187036\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":0,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867327666201020152253","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}