{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:27:35Z","timestamp":1783002455481,"version":"3.54.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"24","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,8,13]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>The development of biodegradable nanoparticles is an important tool for the biological\ntransport of chemical compounds. The nanoencapsulation reduces the biopharmaceutical\nand pharmacokinetic drawbacks of compounds and enhances their biological\nproperties. Naturally occurring polymers such as proteins and polysaccharides have been\nwidely applied in the development of nanostructured systems of several therapeutic\nagents. Among them is chitosan, a crustacean-carapace-chitin derived biopolymer. In addition\nto its biocompatibility and biodegradability, chitosan is known for its mucoadhesion\nproperties. Chitosan-based nanostructured systems potentiate most of the aspects of\nthe loaded drugs, including cellular transport and other biological effects. The use of chitosan\nnanoparticles enhances permeation, stability, and bioactivity of natural compounds.\nIn this review, an overview of the main features of chitosan nanoparticles that improved\nin vitro and in vivo effects of bioactive natural molecules is given, emphasizing the results\nobtained with curcumin.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867328666201124152945","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T05:45:48Z","timestamp":1606283148000},"page":"4935-4953","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chitosan Nanoparticles Potentiate the in vitro and in vivo Effects of Curcumin and other Natural Compounds"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-5924","authenticated-orcid":true,"given":"Vanessa Falchetti","family":"Lopes","sequence":"first","affiliation":[{"name":"Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda \u00c9lio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4659-6634","authenticated-orcid":true,"given":"Camila Nascimento","family":"Giongo","sequence":"additional","affiliation":[{"name":"Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda \u00c9lio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-1024","authenticated-orcid":true,"given":"La\u00eds","family":"de Almeida Campos","sequence":"additional","affiliation":[{"name":"Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda \u00c9lio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-2649","authenticated-orcid":true,"given":"Wolf-Rainer","family":"Abraham","sequence":"additional","affiliation":[{"name":"Helmholtz Center for Infection Research, Inhoffenstra\u00dfe 7, 38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4442-2075","authenticated-orcid":true,"given":"Rubiana Mara","family":"Mainardes","sequence":"additional","affiliation":[{"name":"Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda \u00c9lio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-9944","authenticated-orcid":true,"given":"Najeh Maissar","family":"Khalil","sequence":"additional","affiliation":[{"name":"Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda \u00c9lio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/188327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/188327\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/188327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T05:20:10Z","timestamp":1629177610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/188327\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":0,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,8,13]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867328666201124152945","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}