{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:09:38Z","timestamp":1790276978255,"version":"4.1.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"22","funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["RTI2018-094120-BI00"],"award-info":[{"award-number":["RTI2018-094120-BI00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Vaginal drug delivery offers an opportunity for effective microbicide\ntreatments. However, the physiological characteristics of the vagina represent a\nchallenge when preparing microbicide formulations for local delivery that avoid systemic\neffects.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To review recent advances in vaginal microbicides placing special emphasis\non nanocarriers that encapsulate peptide microbicides. The review includes an overview\nof local treatment and prevention strategies for bactericidal, fungal, protozoal and viral\nvaginal infections that use peptide microbicides.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Scientific literature and clinical trials published in the PubMed database since\n2015 are analyzed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Result:<\/jats:title>\n<jats:p>Peptide microbicides are used for vaginal drug delivery as a means of prevention\nand treatment of several infectious diseases, especially sexually transmitted infections,\nand it is clear that such peptide-based microbicides constitute a suitable strategy. Their\ncombination with nanotechnological drug delivery systems improves local peptide administration\nwhile avoiding their degradation and adverse effects. To date, only a few polymeric\nand lipid-based nanocarriers have been used for peptide microbicide vaginal delivery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The combination of nanotechnology and peptide microbicides has emerged\nover recent years, and different platforms are being used for vaginal peptide delivery.\nNanostructured systems for peptide delivery via vaginal rings or hydrogels are increasingly\nused as platforms capable of providing suitable drug delivery. However, there is still a\nlack of knowledge about nanocarriers aimed at encapsulating peptides for local microbicide\ndelivery.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867328666201209095753","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:44:11Z","timestamp":1607575451000},"page":"4356-4379","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nanotechnology-Based Platforms for Vaginal Delivery of Peptide Microbicides"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-108X","authenticated-orcid":true,"given":"Elena","family":"S\u00e1nchez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona 08028, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-4833","authenticated-orcid":true,"given":"Mar\u00eda Jos\u00e9","family":"G\u00f3mara","sequence":"additional","affiliation":[{"name":"Unit of Synthesis and Biomedical Applications of Peptides, Department of Biological Chemistry, IQAC\u2212 CSIC, Jordi Girona 18, 08034, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-2340","authenticated-orcid":true,"given":"Isabel","family":"Haro","sequence":"additional","affiliation":[{"name":"Unit of Synthesis and Biomedical Applications of Peptides, Department of Biological Chemistry, IQAC\u2212 CSIC, Jordi Girona 18, 08034, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/188888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/188888\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/188888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T10:04:44Z","timestamp":1628071484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/188888\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":0,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,8,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867328666201209095753","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}