{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:42:18Z","timestamp":1783489338703,"version":"3.55.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"29","funder":[{"DOI":"10.13039\/501100005716","name":"Deputy of Research, Babol University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["724132746"],"award-info":[{"award-number":["724132746"]}],"id":[{"id":"10.13039\/501100005716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,9,17]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Neurological disorders (NDs) comprise a broad range of diseases affecting\nboth central and peripheral nervous systems. These complex multifactorial diseases have\na high rate of mortality all over the world, particularly in aged people. Today, new evidence\ndrove our attention to the notable role of noncoding RNAs (ncRNAs) in the progression\nof NDs. Remarkably, recent studies showed that there are close communication\nnetworks among RNA transcripts such as mRNAs, long non-coding RNAs (lncRNAs),\ncircular RNAs (circRNAs), and pseudogenes for regulating each other\u2019s expression\nthrough competing for shared sequences in microRNAs (miRs). This concept is a new\narea of ongoing research recognized as competing endogenous RNA (ceRNA) hypothesis.\nCeRNAs are novel regulatory molecules in a wide range of biological stages and\npathological contexts. Indeed, the disruption of ceRNA networks (ceRNETs) may affect\nneural development genes and induce neuropathological changes leading to the development\nof NDs. Because of this, identifying the correlation of ceRNETs with NDs will\nopen a new window for expanding our knowledge about this field of science, as well as\ncreating novel roads for developing specific diagnostic biomarkers for NDs management.\nOwing to these unique features, exploring the exact role of ceRNAs is a hot topic in NDs\ninvestigations. Hence, in this review, we will summarize the evidence supporting ceRNETs\nin the regulation of NDs-related gene expression.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867328666201217141837","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T07:26:13Z","timestamp":1608276373000},"page":"5983-6010","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-2443","authenticated-orcid":true,"given":"Sadra Samavarchi","family":"Tehrani","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-2639","authenticated-orcid":true,"given":"Reyhane","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-3277","authenticated-orcid":true,"given":"Atiyeh","family":"Al-e-Ahmad","sequence":"additional","affiliation":[{"name":"Student Research Committee, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-3505","authenticated-orcid":true,"given":"Ghodratollah","family":"Panahi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-2883","authenticated-orcid":true,"given":"Reza","family":"Meshkani","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-2103","authenticated-orcid":true,"given":"Simin","family":"Younesi","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Vic., Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5150-4757","authenticated-orcid":true,"given":"Payam","family":"Saadat","sequence":"additional","affiliation":[{"name":"Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-7566","authenticated-orcid":true,"given":"Hadi","family":"Parsian","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189217\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T13:53:25Z","timestamp":1632491605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189217\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":0,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2021,9,17]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867328666201217141837","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication 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