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Recent data from in vitro and clinical studies have suggested that the immune\nsystem influences atherosclerosis, promoting vascular stiffness and vascular aging and\ncontributing to ischemic stroke, intracranial haemorrhage and microbleeds, white matter\ndisease, and cognitive decline. Furthermore, aging is related to a chronic low-grade inflammatory\nstate, in which macrophage, neutrophils, natural killer (NK cells), and B and\nT lymphocytes act as major effectors of the immune-mediated cell responses. Moreover,\noxidative stress and vascular inflammation are correlated with endothelial dysfunction,\nvascular aging, blood-brain barrier disruption, lacunar lesions, and neurodegenerative disorders.\nThis review discusses the pathophysiological roles of fundamental cellular and\nmolecular mechanisms of aging, including the complex interplay between them and innate\nimmunity, as well as vascular dysfunction, arterial stiffness, atherosclerosis,\natherothrombosis, systemic inflammation, and blood-brain barrier dysfunction.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867329666220103101700","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T04:53:17Z","timestamp":1641271997000},"page":"5510-5521","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Immunity, Vascular Aging and Stroke"],"prefix":"10.2174","volume":"29","author":[{"given":"Anna-Maria","family":"Louka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly,\nLarissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Sagris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly,\nLarissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly,\nLarissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/01.RES.0000020401.61826.EA","volume":"90","author":"Csiszar A.","year":"2002","unstructured":"Csiszar A.; Ungvari Z.; Edwards J.G.; Kaminski P.; Wolin M.S.; Koller A.; Kaley G.; Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. 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