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Sydnones undergo thermal 1,3-dipolar cycloaddition reaction\nwith dipolarophiles (alkynes or alkenes) to give exclusively derivatives containing\na pyrazole moiety exhibiting numerous applications, such as pharmaceuticals and agrochemicals.\nHowever, the sydnone cycloaddition reaction with alkynes requires harsh conditions,\nlike high temperatures and long reaction times, giving poor regioselectivity to the\nresulting products. To overcome these constraints, new reactions named CuSAC (Copper-\nCatalyzed Sydnone-Alkyne Cycloaddition) and SPSAC (Strain-Promoted Sydnone-\nAlkyne Cycloaddition) have been developed, leading to pyrazoles with interesting constant\nkinetics.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867329666220620123050","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T06:44:23Z","timestamp":1655793863000},"page":"1122-1144","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sydnone: Synthesis, Reactivity and Biological Activities"],"prefix":"10.2174","volume":"30","author":[{"given":"Souad","family":"Zerbib","sequence":"first","affiliation":[{"name":"Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan\nMoulay Slimane University, BP 523, 23000 Beni-Mellal, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Khouili","sequence":"additional","affiliation":[{"name":"Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan\nMoulay Slimane University, BP 523, 23000 Beni-Mellal, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-304X","authenticated-orcid":true,"given":"Marco","family":"Catto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Pharmaceutical\nSciences, University of Bari Aldo Moro, via E. 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