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Some polyphenols\nhave improved mitochondrial function in different NAFLD and obesity models.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The study aims to discuss the potential role of polyphenols as a nonpharmacological\napproach targeting mitochondria to prevent and treat NAFLD, analyzing\nthe influence of polyphenols' chemical structure, limitations and clinical projections.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In vivo and in vitro NAFLD models were considered. Study searches were performed\nusing the following keywords: nonalcoholic fatty liver disease, liver steatosis, mitochondria,\nmitochondrial activity, mitochondrial dynamics, mitochondrial dysfunction,\nmitochondrial morphology, mitochondrial cristae, fusion, fission, polyphenols, flavonoids,\nanthocyanins, AND\/OR bioactive compounds.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Polyphenols are a group of diverse bioactive molecules whose bioactive effects\nare highly determined by their chemical structure. These bioactive compounds could\noffer an interesting non-pharmacological approach to preventing and treating NAFLD,\nregulating mitochondrial dynamics and function. Nevertheless, the mitochondria' role in\nsubjects with NAFLD treatment is not fully elucidated. The dosage and bioavailability of\nthese compounds should be addressed when studied.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867329666221007115809","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T04:57:01Z","timestamp":1665377821000},"page":"2977-2995","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeting Mitochondria for the Prevention and Treatment of Nonalcoholic\nFatty Liver Disease: Polyphenols as a Non-pharmacological\nApproach"],"prefix":"10.2174","volume":"30","author":[{"given":"Jaime","family":"Zapata","sequence":"first","affiliation":[{"name":"Escuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-299X","authenticated-orcid":true,"given":"Mauricio","family":"Castro-Sepulveda","sequence":"additional","affiliation":[{"name":"Escuela de Kinesiologia,\nFacultad de Medicina, Universidad Finis Terrae, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Soto-Alarcon","sequence":"additional","affiliation":[{"name":"Carrera de Nutricion y Dietetica,\nFacultad de Ciencias de la Salud, Universidad Autonoma de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinologia\ny Metabolismo, Campus Occidente, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-2382","authenticated-orcid":true,"given":"Andres","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Departamento de Nutricion, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiselle","family":"Villarroel","sequence":"additional","affiliation":[{"name":"Escuela de Nutricion\ny Dietetica, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-0553","authenticated-orcid":true,"given":"Diego Fernando","family":"Garcia-Diaz","sequence":"additional","affiliation":[{"name":"Departamento de Nutricion, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Departamento de Nutricion, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9661-0377","authenticated-orcid":true,"given":"Francisca","family":"Echeverria","sequence":"additional","affiliation":[{"name":"Departamento de Nutricion, Facultad de Medicina, Universidad de Chile, Santiago, Chile"},{"name":"Carrera Nutricion y Dietetica,\nDepartamento Ciencias de la Salud, Pontificia Universidad Catolica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","volume":"71","author":"Younossi Z.M.","year":"2019","unstructured":"Younossi Z.M.; Golabi P.; de Avila L.; Paik J.M.; Srishord M.; Fukui N.; Qiu Y.; Burns L.; Afendy A.; Nader F.; The global epidemiology of NAFLD and NASH in patients with type 2 diabetes via systematic review and meta-analysis. 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