{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:22:54Z","timestamp":1781104974476,"version":"3.54.1"},"reference-count":49,"publisher":"Bentham Science Publishers Ltd.","issue":"15","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The Brugada syndrome (BrS) is a heart rhythm condition that is\ncommonly associated with a strong predisposition for sudden cardiac death. Malignant\nventricular arrhythmias could occur secondary to the dysfunction of the cardiac sodium\nvoltage-gated Na(v)1.5 channel (SCN5A).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aimed to perform a multiparametric computational analysis of the\nphysicochemical properties of SCN5A mutants associated with BrS using a set of bioinformatics\ntools.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In-house algorithms were calibrated to calculate, in a double-blind test, the Polarity\nIndex Method (PIM) profile and protein intrinsic disorder predisposition (PIDP)\nprofile of each sequence, and computer programs specialized in the genomic analysis\nwere used.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Specific regularities in the charge\/polarity and PIDP profile of the SCN5A mutant\nproteins enabled the re-creation of the taxonomy, allowing us to propose a bioinformatics\nmethod that takes advantage of the PIM profile to identify this group of proteins\nfrom their sequence.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Bioinformatics programs could reproduce characteristic PIM and PIDP profiles\nof the BrS-related SCN5A mutant proteins. This information can contribute to a better\nunderstanding of these altered proteins.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867330666221130112650","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T12:17:25Z","timestamp":1669983445000},"page":"1776-1796","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioinformatics Insights on the Physicochemical Properties of SCN5A\nMutant Proteins Associated with the Brugada Syndrome"],"prefix":"10.2174","volume":"30","author":[{"given":"Carlos","family":"Polanco","sequence":"first","affiliation":[{"name":"Department of Electromechanical Instrumentation, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, Mexico City 14080, Mexico"},{"name":"Department of Mathematics, Faculty of Sciences, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlio F.","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Electrophysiology Department, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, Mexico City, 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir N.","family":"Uversky","sequence":"additional","affiliation":[{"name":"Department of\nMolecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida,\nTampa, FL, 33647, USA"},{"name":"Protein Research Group, Institute for Biological Instrumentation of the Russian Academy of Sciences,\nFederal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, 142290\nPushchino, Moscow region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique H.","family":"Lemus","sequence":"additional","affiliation":[{"name":"Department of Computational Genomics, Instituto Nacional de Medicina Gen\u00f3mica, Mexico\nCity 14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Huberman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n &#34;Salvador Zubir\u00e1n&#34;, 14080,\nMexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Buhse","sequence":"additional","affiliation":[{"name":"Chemical Research Center, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca, Morelos, 62209,\nMexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha R.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Electromechanical Instrumentation, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","volume":"20","author":"Brugada P.","year":"1992","unstructured":"Brugada P.; Brugada J.; Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. 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