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Liver fibrosis is now considered to be a reversible pathophysiological process and suppression of fibrosis is necessary to prevent liver cancer. At present, no specific drugs have been found that have hepatic anti-fibrotic activity<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The research progress of anti-hepatic fibrosis compounds in recent ten years was reviewed to provide a reference for the design and development of anti-hepatic fibrosis drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>According to the structure of the compounds, they are divided into monocyclic compounds, fused-heterocyclic compounds, and acyclic compounds.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>In this article, the natural products and synthetic compounds with anti-fibrotic activity in recent ten years were reviewed, with emphasis on their pharmacological activity and structure-activity relationship (SAR).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Most of these compounds are natural active products and their derivatives, and there are few researches on synthetic compounds and SAR studies on natural product.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867331666230727102016","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T09:49:49Z","timestamp":1690451389000},"page":"2571-2628","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Recent Advances in Research on Active Compounds Against Hepatic\nFibrosis"],"prefix":"10.2174","volume":"31","author":[{"given":"Chuang","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-4845","authenticated-orcid":true,"given":"Cheng-Hua","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China"},{"name":"Interdisciplinary of Biological Functional Molecules, College of Integration Science, Yanbian University, Yanji, Jilin, 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S2468-1253(19)30342-5","volume":"5","author":"Sarin S.K.","year":"2020","unstructured":"Sarin S.K.; Kumar M.; Eslam M.; George J.; Al Mahtab M.; Akbar S.M.F.; Jia J.; Tian Q.; Aggarwal R.; Muljono D.H.; Omata M.; Ooka Y.; Han K.H.; Lee H.W.; Jafri W.; Butt A.S.; Chong C.H.; Lim S.G.; Pwu R.F.; Chen D.S.; Liver diseases in the Asia-Pacific region: A lancet gastroenterology and hepatology commission. 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