{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:40:04Z","timestamp":1793742004103,"version":"4.6.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"28","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2019,10,21]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Cancer is the major public health problem in developing countries. The treatment of\ncancer requires a multimodal approach and chemotherapy is one of them. Chemotherapeutic drug is administered\nto cancer patients in the form of a formulation which is prepared by mixing an active ingredient (drug) with the\nexcipient. The role of excipient in a formulation is to regulate the release, bio-distribution, and selectivity of drug\nwithin the body.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In this context, selectivity of an anticancer formulation is achieved through two mechanisms like passive\nand active targeting. The passive targeting of a formulation is generally through enhanced permeation retention\n(EPR) effect which is dictated by physical properties of the carrier such as shape and size. On the contrary,\nactive targeting means surface functionalization of excipient with target-specific ligands and\/or receptors to increase\nits selectivity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Over the past several decades, remarkable progress has been made in the development and application of\nan engineered excipient or carrier to treat cancer more effectively. Especially nanoparticulate systems composed\nof metal\/liposomes\/polymeric material\/proteins have received significant attention in the rational design of anticancer\ndrug formulations; for example, therapeutic agents have been integrated with nanoparticles of optimal\nsizes, shapes and surface properties to improve their solubility, circulation half-life, and bio-distribution. In this\nreview article, recent literature is included to discuss the role of physicochemical properties of excipients in\nachieving tumour targeting through passive and active approaches.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The selection of an excipient\/carrier and targeting ligand plays a very important role in rational\ndesign and development of anticancer drug formulations.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612825666190830155319","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:05:41Z","timestamp":1567209941000},"page":"3034-3056","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Passive and Active Drug Targeting: Role of Nanocarriers in Rational Design of Anticancer Formulations"],"prefix":"10.2174","volume":"25","author":[{"given":"Ram P.","family":"Das","sequence":"first","affiliation":[{"name":"Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai - 400085, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa V.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai - 400085, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena G.","family":"Singh","sequence":"additional","affiliation":[{"name":"Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai - 400085, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kunwar","sequence":"additional","affiliation":[{"name":"Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai - 400085, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/174588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T10:50:22Z","timestamp":1571655022000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/174588\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":0,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2019,10,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612825666190830155319","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}