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Among these kind of materials naturally occurring\npolymers - proteins which constituted one of the most important \u201cbricks of life\u201d - \u03b1-amino acids (AAs) are\nhighly suitable. A wide biomedical applicability of proteins is due to special properties such as a high affinity\nwith tissues and releasing AAs upon biodegradation that means a nutritive potential for cells. Along with these\npositive characteristics proteins as biomedical materials they have some shortcomings, such as batch-to-batch\nvariation, risk of disease transmission, and immune rejection. The last limitation is connected with the molecular\narchitecture of proteins. Furthermore, the content of only peptide bonds in protein molecules significantly restricts\ntheir material properties. Artificial polymers with the composition of AAs are by far more promising as degradable\nbiomaterials since they are free from the limitations of proteins retaining at the same time their positive\nfeatures - a high tissue compatibility and nutritive potential. The present review deals with a brief description of\ndifferent families of AA-based artificial polymers, such as poly(amino acid)s, pseudo-poly(amino acid)s, polydepsipeptides,\nand pseudo-proteins - relatively new and broad family of artificial AA-based DPs. Most of these\npolymers have a different macromolecular architecture than proteins and contain various types of chemical links\nalong with NH-CO bonds that substantially expands properties of materials destined for sophisticated biomedical\napplications.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612826666200203122110","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T12:39:53Z","timestamp":1580733593000},"page":"566-593","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Artificial Polymers made of \u03b1-amino Acids - Poly(Amino Acid)s, Pseudo-Poly(Amino Acid)s, Poly(Depsipeptide)s, and Pseudo-Proteins"],"prefix":"10.2174","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-1571","authenticated-orcid":true,"given":"Nino","family":"Zavradashvili","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, # 240 David Aghmashenebeli Alley, Tbilisi 0131, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-4474","authenticated-orcid":true,"given":"Jordi","family":"Puiggali","sequence":"additional","affiliation":[{"name":"Departament d\u2019Enginyeria Quimica, EEBE, Universitat Politecnica de Catalunya, Edifici I.2, C\/Eduard Maristany, 10-14, Barcelona 08019, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-1514","authenticated-orcid":true,"given":"Ramaz","family":"Katsarava","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, # 240 David Aghmashenebeli Alley, Tbilisi 0131, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s10924-011-0317-1","volume":"19","author":"Luckachan G.E.","year":"2011","unstructured":"Luckachan G.E.; Pillai C.K.; Biodegradable polymers - a review on recent trends and emerging perspectives. 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