{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:33:48Z","timestamp":1782977628311,"version":"3.54.5"},"reference-count":42,"publisher":"Bentham Science Publishers Ltd.","issue":"33","funder":[{"name":"Innovative Talents Support Program for Universities in Liaoning Province","award":["LR2019028"],"award-info":[{"award-number":["LR2019028"]}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Epigallocatechin gallate (EGCG) is the main component of rhubarb tannin, with antioxidant, anti-angiogenic, anti-cancer and antiviral activities. Diabetes mellitus (DM) is a high blood sugar and\nprotein metabolism disorder syndrome, which is caused by absolute or relative factors, such as deficiency of\ninsulin and oxidative stress. Diabetes cardiomyopathy (DCM) is one of the most frequent complications of DM.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aims to explore whether EGCG can improve diabetic complication, myocardial fibrosis,\nin diabetic rats with an intraperitoneal injection of streptozotocin (STZ) through the transforming growth factor\n\u03b21 (TGF-\u03b21)\/C-Jun N -terminal kinase (JNK) signaling pathway.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>50 male SD rats were randomly divided into five groups, including the control group, model group,\nand EGCG drug groups (10 mg\/kg, 20 mg\/kg, 40 mg\/kg), with 10 rats in each group. Rats, except for the control group, were intraperitoneally injected with STZ (65 mg\/kg) to induce the diabetic rats model. EGCG drug\ngroups were given distilled water according to the dose, while the control group and model group were given\nthe same volume of distilled water for 12 weeks. The levels of glucose (GLU), triglyceride (TG), cholesterol\n(CHO), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) in serum were detected by ELISA\nof all rats. Myocardial function was observed by HE, Masson staining and Sirius red staining in DCM rats. Immunohistochemistry was used to detect the expression of Collagen I (COL-I) and Collagen III (COL-III), and\ndetect the degree of myocardial fibrosis of DM rats. Western blot was used to detect the expression of matrix\nmetalloproteinases (MMPs), tissue inhibitor of matrix metalloproteinase (TIMPs), TGF-\u03b21, JNK and p-JNK in\nthe myocardium.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Compared to the model group, the levels of GLU, TG, CHO, and LDL in serum were decreased while the\nlevel of HDL in serum was increased in EGCG groups rats; cardiac index and left ventricular mass index were decreased while heart function was improved in EGCG groups rats; the expressions of the COL-I and COL-III were\ndecreased in EGCG groups, and the high dose group was the best; the expressions of TGF-\u03b21, JNK, p-JNK, and\nTIMP-1 were down-regulated, and the expression of MMP-9 was up-regulated in EGCG groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The results demonstrated that EGCG could improve STZ-induced diabetic complication, i.e., myocardial fibrosis, in diabetic rats, and protect their heart through TGF-\u03b21\/JNK signaling pathway<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612828666220902115437","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T12:45:26Z","timestamp":1662209126000},"page":"2758-2770","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epigallocatechin Gallate Protects Diabetes Mellitus Rats Complicated with Cardiomyopathy\nthrough TGF-\u03b21\/JNK Signaling Pathway"],"prefix":"10.2174","volume":"28","author":[{"given":"Liuming","family":"Gui","sequence":"first","affiliation":[{"name":"College of Basic Medicine, Jinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Jinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangka","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica,\nJinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Jinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Jinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxiaorui","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica,\nJinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushuang","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Jinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica,\nJinzhou Medical University, JinZhou, Liaoning Province, 121000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1753-0407.2011.00144.x","volume":"3","author":"Dixon J.B.","year":"2011","unstructured":"Dixon J.B.; Zimmet P.; Alberti K.G.; Mbanya J.C.; Rubino F.; Bariatric surgery for diabetes: The International Diabetes Federation takes a position. 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