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This derives from tissue lipotoxicity, oxidative stress, fibrosis,\nand inflammation, resulting in structural and functional changes that lead to glomerular and tubule-interstitial\ndamage. Some authors indicate that a lipid-lowering pharmacological approach combined with a substantial\nlifestyle change should be considered to treat chronic kidney disease (CKD). Also, the new therapeutic target\nidentification and the development of new drugs targeting metabolic pathways involved with kidney lipotoxicity\ncould constitute an additional alternative to combat the complex mechanisms involved in impaired kidney\nfunction. In this review article, we first provide the pathophysiological evidence regarding the impact of hypercaloric\ndiets, such as high-fat diets and high-fructose diets, on the development of metabolic disorders associated\nwith impaired renal function and the molecular mechanisms underlying tissue lipid deposition. In addition,\nwe present the current progress regarding translational strategies to prevent and\/or treat kidney injury related to\nthe consumption of hypercaloric diets.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612829666221020162955","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T07:02:31Z","timestamp":1666335751000},"page":"3127-3139","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hypercaloric Diet Promotes Metabolic Disorders and Impaired Kidney Function"],"prefix":"10.2174","volume":"28","author":[{"given":"Cecilia Gabriela","family":"Mel\u00e9ndez-Salcido","sequence":"first","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas, Divisi\u00f3n de Ciencias de la Salud, Campus Le\u00f3n, Universidad de Guanajuato, 20 de enero, 929\nCol. Obreg\u00f3n CP 37320. 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