{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:50:24Z","timestamp":1740142224616,"version":"3.37.3"},"reference-count":35,"publisher":"Bentham Science Publishers Ltd.","issue":"7","funder":[{"DOI":"10.13039\/501100007615","name":"University of Dammam","doi-asserted-by":"publisher","award":["2019-072-IRMC"],"award-info":[{"award-number":["2019-072-IRMC"]}],"id":[{"id":"10.13039\/501100007615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["COS"],"published-print":{"date-parts":[[2019,12,26]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Presently, rise in the infectious diseases and subsequent development of drug\nresistance, is a global threat to human health. However, much efforts are being made by scientists, to develop\nnovel antimicrobials, and also to improve the efficacy of available drugs, in order to combat the lifethreatening\ninfections.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Synthesis and characterization of azole functional polymer systems for antimicrobial applications.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>Poly(glycidyl methacrylate) (PGMA), was produced by free radical polymerization\nof the monomer, glycidyl methacrylate (GMA). Different azole functional PGMAs were produced, through\nchemical modification with imidazole (Im), 1H-1,2,4-triazole (Tri) and 3-amino-1,2,4-triazole (ATri), to get\nPGMA-Imi, PGMA-Tri and PGMA-ATri, respectively. The structure was confirmed by Fourier transform\ninfrared spectroscopy (FT-IR), thermal properties were investigated by Thermogravimetric Analysis (TGA),\nand surface morphology was studied by scanning electron microscopy (SEM). Newly synthesized derivatives\nwere further explored, for their antibacterial and anticandidal activities.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> All the three synthesized and characterized derivatives, displayed a significant activity against the\ntested microorganisms. The minimum inhibitory concentration (MIC) and minimum bactericidal\/fungicidal\nconcentration (MBC\/MFC), recorded against Staphylococcus aureus (S. aureus), was 0.5 &amp;1mg\/ml for\nPGMA-Imi, followed by PGMA-ATri &amp; PGMA-Tri, respectively, followed by E. coli with, 1 &amp; 2 mg\/ml, 4\n&amp; 8 mg\/ml, 4&amp; 8 mg\/ml, respectively, whereas the maximum MIC &amp; MFC was recorded against C. albicans\ni.e., 8 &amp; 16 mg\/ml, 4 &amp; 8 mg\/ml ,4 &amp; 8 mg\/ml for PGMA-ATri, PGMA-Tri, PGMA-Imi, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In the present work, we report on the state-of-the-art, azole functional polymer systems for\nantimicrobial applications. These findings suggest that the synthesized azole functional polymer films have\nantimicrobial properties, which could be potential candidates for coating applications in the biomedical and\nwastewater treatment field.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1385272823666190828112113","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T09:21:41Z","timestamp":1568280101000},"page":"1002-1009","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Characterization of Novel Azole Functionalized Poly(glycidyl methacrylate)s for Antibacterial and Anticandidal Activity"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3087-852X","authenticated-orcid":true,"given":"Suriya","family":"Rehman","sequence":"first","affiliation":[{"name":"Epidemic Disease Research Department, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. 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