{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:50:51Z","timestamp":1740142251571,"version":"3.37.3"},"reference-count":36,"publisher":"Bentham Science Publishers Ltd.","issue":"4","funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY17A0110012"],"award-info":[{"award-number":["LY17A0110012"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Zhejiang provincial & Ministry of Health Research Fund for Medical Sciences","doi-asserted-by":"publisher","award":["WKJ-ZJ-1828"],"award-info":[{"award-number":["WKJ-ZJ-1828"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou City","doi-asserted-by":"publisher","award":["WKJ-ZJ-1828"],"award-info":[{"award-number":["WKJ-ZJ-1828"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2019,7,24]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Assisted reproductive techniques (ART) have been extensively used to\ntreat infertility. Inaccurate prediction of a couple\u2019s fertility often leads to lowered self-esteem for\npatients seeking ART treatment and causes fertility distress.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This prospective study aimed to statistically analyze patient data from a single\nreproductive medical center over a period of 18 months, and to establish mathematical models that\nmight facilitate accurate prediction of successful pregnancy when ART are used.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In the present study, we analyzed clinical data prospectively collected from 760 infertile\npatients visiting the second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou\nMedical University between June 1, 2016 and December 31, 2017. Various advanced statistical\nmethods, including broken-line regression, were employed to analyze the data.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Age remained the most important factor affecting the outcome of IVF\/ICSI. Using the\nbroken-line regression model, the fastest clinical pregnancy declining age was between 25 and 32.\nFemale infertility type was found to be a key predictor for the number of good-quality embryos and\nsuccessful pregnancy, along with the antral follicle count (AFC), total number of embryos,\nrecombinant follicle stimulating hormones (rFSH) dosage, estradiol (E2) on the trigger day, and\ntotal number of oocytes retrieved. rFSH dosage was also significantly associated with the number\nof oocytes retrieved and the number of frozen embryos.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The fastest clinical pregnancy declining age is ranged between 25 and 32, and female\ninfertility type is evidenced as another key predictive factor for the cumulative outcome of ART.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207322666190404145448","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T05:41:52Z","timestamp":1554788512000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Statistical Modelling Outcome of In Vitro Fertilization and Intracytoplasmic Sperm Injection: A Single Centre Study"],"prefix":"10.2174","volume":"22","author":[{"given":"Boyun","family":"Xu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianfen","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL 33431, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Qu","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University-Monash Biomedicine Discovery Institute Alliance in Clinical Experimental Biomedicine, Wenzhou 325027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijue","family":"Su","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialing","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nm1001-1079","volume":"7","author":"Goldstein J.L.","year":"2001","unstructured":"Goldstein JL. 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