{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:20:27Z","timestamp":1767666027980,"version":"3.37.3"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"9","funder":[{"DOI":"10.13039\/501100007071","name":"Harran \u00dcniversitesi","doi-asserted-by":"publisher","award":["18207"],"award-info":[{"award-number":["18207"]}],"id":[{"id":"10.13039\/501100007071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n<jats:title>Aim and Objective::<\/jats:title>\n<jats:p>To determine the mechanisms present in the etiopathogenesis of nasal\npolyposis. It is not clear whether amino acids contribute in a causal way to the development of the\ndisease. Therefore, the aim of this study was to determine the plasma-free amino acid profile in\npatients with nasal polyposis and to compare the results with a healthy control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods::<\/jats:title>\n<jats:p>This was a prospective controlled study that took place in the Otolaryngology\nDepartment at the Harran University Faculty of Medicine between April 2017 and April 2018. Plasmafree\namino acid profile levels were studied in serum samples taken from a patient group and a healthy\ncontrol group. Patients who were diagnosed with bilateral diffuse nasal polyposis and were scheduled\nfor surgical interventions were included in this study. Individuals whose age, gender, and body mass\nindex values were compatible with that of the patient group and who did not have any health problems\nwere included in the control group. All the participants whose levels of plasma-free amino acid were\nthought to be affected by one or more of the following factors were excluded from the study: smoking\nand alcohol use, allergic rhinitis presence, the presence of acute or chronic sinusitis, a history of\nendoscopic sinus surgery, unilateral nasal masses, a history of chronic drug use, systemic or topical\nsteroid use in the last three months for any reason, and liver, kidney, hematological, cardiovascular,\nmetabolic, neurological, or psychiatric disorders or malignancies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> In patients with nasal polyposis, 3-methyl histidine (3-MHIS: nasal polyposis group (ng) = 3.22\n(1.92 \u2013 6.07); control group (cg) = 1.21 (0.77 \u2013 1.68); p = 0.001); arginine (arg: ng = 98.95 (70.81 \u2013\n117.75); cg = 75.10 (54.49 \u2013 79.88); p = 0.005); asparagine (asn: ng = 79.84 (57.50 \u2013 101.44); cg = 60.66\n(46.39 \u2013 74.62); p = 0.021); citrulline (cit: ng = 51.83 (43.81 \u2013 59.78); cg = 38.33 (27.81 \u2013 53.73); p =\n0.038); cystine (cys: ng = 4.29 (2.43 \u2013 6.66); cg = 2.41 (1.51 \u2013 4.16); p = 0.019); glutamic acid (glu: ng =\n234.86 (128.75 \u2013 286.66); cg = 152.37 (122.51 \u2013 188.34); p = 0.045); histidine (his: ng = 94.19 (79.34 \u2013\n113.99); cg = 74.80 (62.76 \u2013 98.91); p = 0.018); lysine (lys: ng = 297.22 (206.55 \u2013 371.25); cg = 179.50\n(151.58 \u2013 238.02); p = 0.001); ornithine (ng = 160.62 (128.36 \u2013 189.32); cg = 115.91 (97.03 \u2013 159.91); p\n= 0.019); serine (ser: ng = 195.15 (151.58 \u2013 253.07); cg = 83.07 (67.44 \u2013 92.44); p = 0.001); taurine (tau:\nng = 74.69 (47.00 \u2013 112.13); cg = 53.14 (33.57 \u2013 67.31); p = 0.006); tryptophan (trp: ng = 52.31 (33.81 \u2013\n80.11); cg = 34.44 (25.94 \u2013 43.07); p = 0.005), homocitrulline (ng = 1.75 (1.27 \u2013 2.59); cg = 0.00 (0.00 \u2013\n0.53); p = 0.001); norvaline (ng = 6.90 (5.61 \u2013 9.18); cg = 4.93 (3.74 \u2013 7.13); p = 0.021); argininosuccinic\nacid (ng = 14.33 (10.06 \u2013 25.65); cg = 12.22 (5.77 \u2013 16.87) p = 0.046); and plasma concentrations were\nsignificantly higher than in the healthy control group (p &lt;0.05). However, the gamma-aminobutyric acid\n(gaba: ng = 0.16 (0.10 \u2013 0.24); cg = 0.21 (0.19 \u2013 0.29); p = 0.010) plasma concentration was significantly\nlower in the nasal polyposis group than in the healthy control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this study, plasma levels of 15 free amino acids were significantly higher in the nasal\npolyposis group than in the healthy control group. A plasma level of 1 free amino acid was found to be\nsignificantly lower in the nasal polyposis group compared to the healthy control group. Therefore, it is\nimportant to determine the possibility of using the information obtained to prevent the recurrence of\nthe condition and to develop effective treatment strategies. This study may be a milestone for studies of\nthis subject. However, this study needs to be confirmed by further studies conducted in a larger series.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207322666190920110324","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T09:38:34Z","timestamp":1568972314000},"page":"657-662","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma-Free Amino Acid Profiling of Nasal Polyposis Patients"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-2518","authenticated-orcid":true,"given":"Mustafa","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Harran University Medical Faculty, Sanliurfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-5214","authenticated-orcid":true,"given":"Alper","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Harran University Medical Faculty, Sanliurfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4757","authenticated-orcid":true,"given":"\u0130smail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Harran University Medical Faculty, Sanliurfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-1537","authenticated-orcid":true,"given":"Ataman","family":"G\u00f6nel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Harran University Medical Faculty, Sanliurfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00130832-200302000-00001","volume":"3","author":"Pawankar R.","year":"2003","unstructured":"Pawankar R.; Nasal polyposis: an update: editorial review. Curr Opin Allergy Clin Immunol 2003,3(1),1-6","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3109\/10715762.2010.535531","volume":"45","author":"Vinokur V.","year":"2011","unstructured":"Vinokur V.; Berenshtein E.; Chevion M.M.; Eliashar R.; Iron homeostasis and methionine-centred redox cycle in nasal polyposis. Free Radic Res 2011,45(3),366-373","journal-title":"Free Radic Res"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1146\/annurev.bi.44.070175.004441","volume":"44","author":"Felig P.","year":"1975","unstructured":"Felig P.; Amino acid metabolism in man. Annu Rev Biochem 1975,44(1),933-955","journal-title":"Annu Rev Biochem"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"2068S","DOI":"10.1093\/jn\/133.6.2068S","volume":"133","author":"Brosnan J.T.","year":"2003","unstructured":"Brosnan J.T.; Interorgan amino acid transport and its regulation. J Nutr 2003,133,2068S-2072S","journal-title":"J Nutr"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1152\/physrev.1982.62.4.1193","volume":"62","author":"Christensen H.N.","year":"1982","unstructured":"Christensen H.N.; Interorgan amino acid nutrition. Physiol Rev 1982,62(4 Pt 1),1193-1233","journal-title":"Physiol Rev"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0026-0495(73)90054-1","volume":"22","author":"Armstrong M.D.","year":"1973","unstructured":"Armstrong M.D.; Stave U.; A study of plasma free amino acid levels. V. Correlations among the amino acids and between amino acids and some other blood constituents. Metabolism 1973,22(6),827-833","journal-title":"Metabolism"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/0026-0495(73)90053-X","volume":"22","author":"Armstrong M.D.","year":"1973","unstructured":"Armstrong M.D.; Stave U.; A study of plasma free amino acid levels. IV. Characteristic individual levels of the amino acids. Metabolism 1973,22(6),821-825","journal-title":"Metabolism"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/0026-0495(73)90069-3","volume":"22","author":"Armstrong M.D.","year":"1973","unstructured":"Armstrong M.D.; Stave U.; A study of plasma free amino acid levels. II. Normal values for children and adults. Metabolism 1973,22(4),561-569","journal-title":"Metabolism"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0378-4347(00)80685-4","volume":"379","author":"Deyl Z.","year":"1986","unstructured":"Deyl Z.; Hyanek J.; Horakova M.; Profiling of amino acids in body fluids and tissues by means of liquid chromatography. J Chromatogr A 1986,379,177-250","journal-title":"J Chromatogr A"},{"key":"ref=10","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.4.1.93","volume":"4","author":"Kim Y.S.","year":"2008","unstructured":"Kim Y.S.; Maruvada P.; Milner J.A.; Metabolomics in biomarker discovery: future uses for cancer prevention. Future Oncol 2008,4(1)","journal-title":"Future Oncol"},{"key":"ref=11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024143","volume":"6","author":"Miyagi Y.","year":"2011","unstructured":"Miyagi Y.; Higashiyama M.; Gochi A.; Akaike M.; Ishikawa T.; Miura T.; Saruki N.; Bando E.; Kimura H.; Imamura F.; Moriyama M.; Ikeda I.; Chiba A.; Oshita F.; Imaizumi A.; Yamamoto H.; Miyano H.; Horimoto K.; Tochikubo O.; Mitsushima T.; Yamakado M.; Okamoto N.; Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One 2011,6(9)","journal-title":"PLoS One"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1002\/1097-0142(19841101)54:9<1875:AID-CNCR2820540918>3.0.CO;2-O","volume":"54","author":"Watanabe A.","year":"1984","unstructured":"Watanabe A.; Higashi T.; Sakata T.; Nagashima H.; Serum amino acid levels in patients with hepatocellular carcinoma. Cancer 1984,54(9),1875-1882","journal-title":"Cancer"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"5853","DOI":"10.1007\/s11033-013-2691-3","volume":"40","author":"Hasim A.","year":"2013","unstructured":"Hasim A.; Aili A.; Maimaiti A.; Mamtimin B.; Abudula A.; Upur H.; Plasma-free amino acid profiling of cervical cancer and cervical intraepithelial neoplasia patients and its application for early detection. Mol Biol Rep 2013,40(10),5853-5859","journal-title":"Mol Biol Rep"},{"key":"ref=14","first-page":"507","volume":"15","author":"Cascino A.","year":"1995","unstructured":"Cascino A.; Muscaritoli M.; Cangiano C.; Conversano L.; Laviano A.; Ariemma S.; Meguid M.M.; Rossi Fanelli F.; Plasma amino acid imbalance in patients with lung and breast cancer. Anticancer Res 1995,15(2),507-510","journal-title":"Anticancer Res"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.juro.2011.05.085","volume":"186","author":"Mustafa A.","year":"2011","unstructured":"Mustafa A.; Gupta S.; Hudes G.R.; Egleston B.L.; Uzzo R.G.; Kruger W.D.; Serum amino acid levels as a biomarker for renal cell carcinoma. J Urol 2011,186(4),1206-1212","journal-title":"J Urol"},{"key":"ref=16","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2016.55","volume":"7","author":"Bi X.","year":"2017","unstructured":"Bi X.; Henry C.J.; Plasma-free amino acid profiles are predictors of cancer and diabetes development. Nutr Diabetes 2017,7(3)","journal-title":"Nutr Diabetes"},{"key":"ref=17","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2016.5","volume":"6","author":"Tochikubo O.","year":"2016","unstructured":"Tochikubo O.; Nakamura H.; Jinzu H.; Nagao K.; Yoshida H.; Kageyama N.; Miyano H.; Weight loss is associated with plasma free amino acid alterations in subjects with metabolic syndrome. Nutr Diabetes 2016,6(2)","journal-title":"Nutr Diabetes"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/00075197-199901000-00009","volume":"2","author":"Holm E.","year":"1999","unstructured":"Holm E.; Sedlaczek O.; Grips E.; Amino acid metabolism in liver disease. Curr Opin Clin Nutr Metab Care 1999,2(1),47-53","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref=19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159205","volume":"11","author":"Kinny-K\u00f6ster B.","year":"2016","unstructured":"Kinny-K\u00f6ster B.; Bartels M.; Becker S.; Scholz M.; Thiery J.; Ceglarek U.; Kaiser T.; Plasma amino acid concentrations predict mortality in patients with end-stage liver disease. PLoS One 2016,11(7)","journal-title":"PLoS One"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S1051-2276(98)90035-8","volume":"8","author":"Hong S-Y.","year":"1998","unstructured":"Hong S-Y.; Yang D-H.; Chang S-K.; The relationship between plasma homocysteine and amino acid concentrations in patients with end-stage renal disease. J Ren Nutr 1998,8(1),34-39","journal-title":"J Ren Nutr"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1083\/jcb.201403009","volume":"206","author":"Chen R.","year":"2014","unstructured":"Chen R.; Zou Y.; Mao D.; Sun D.; Gao G.; Shi J.; Liu X.; Zhu C.; Yang M.; Ye W.; Hao Q.; Li R.; Yu L.; The general amino acid control pathway regulates mTOR and autophagy during serum\/glutamine starvation. J Cell Biol 2014,206(2),173-182","journal-title":"J Cell Biol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1080\/14756366.2018.1481403","volume":"33","author":"Koyuncu I.","year":"2018","unstructured":"Koyuncu I.; Gonel A.; Kocyigit A.; Temiz E.; Durgun M.; Supuran C.T.; Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells. J Enzyme Inhib Med Chem 2018,33(1),1137-1149","journal-title":"J Enzyme Inhib Med Chem"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1080\/00016480510029293","volume":"125","author":"Lee S.H.","year":"2005","unstructured":"Lee S.H.; Kim W.S.; Lee S.H.; Oh J.W.; Lee H.M.; Jung H.H.; Jang J.W.; Jun Y.J.; Cho W.J.; Jhun H.S.; Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp. Acta Otolaryngol 2005,125(8),877-882","journal-title":"Acta Otolaryngol"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11306-018-1383-3","volume":"14","author":"Rhee S.Y.","year":"2018","unstructured":"Rhee S.Y.; Jung E.S.; Park H.M.; Jeong S.J.; Kim K.; Chon S.; Yu S-Y.; Woo J-T.; Lee C.H.; Plasma glutamine and glutamic acid are potential biomarkers for predicting diabetic retinopathy. Metabolomics 2018,14(7),89","journal-title":"Metabolomics"},{"key":"ref=25","first-page":"595","volume":"11","author":"Rossi Fanelli F.","year":"1995","unstructured":"Rossi Fanelli F.; Cangiano C.; Muscaritoli M.; Conversano L.; Torelli G.F.; Cascino A.; Tumor-induced changes in host metabolism: A possible marker of neoplastic disease. Nutrition 1995,11(5),595-600","journal-title":"Nutrition"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1096\/fasebj.11.1.9034170","volume":"11","author":"Hack V.","year":"1997","unstructured":"Hack V.; Schmid D.; Breitkreutz R.; Stahl-Henning C.; Drings P.; Kinscherf R.; Taut F.; Holm E.; Dr\u00f6ge W.; Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV\/SIV infection, and senescence. FASEB J 1997,11(1),84-92","journal-title":"FASEB J"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0022-4804(03)00090-8","volume":"111","author":"Kaufmann Y.","year":"2003","unstructured":"Kaufmann Y.; Luo S.; Johnson A.; Babb K.; Klimberg V.S.; Timing of oral glutamine on DMBA-induced tumorigenesis. J Surg Res 2003,111(1),158-165","journal-title":"J Surg Res"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/j.1939-4640.2003.tb02665.x","volume":"24","author":"Lamb D.J.","year":"2003","unstructured":"Lamb D.J.; Puxeddu E.; Malik N.; Stenoien D.L.; Nigam R.; Saleh G.Y.; Mancini M.; Weigel N.L.; Marcelli M.; Molecular analysis of the androgen receptor in ten prostate cancer specimens obtained before and after androgen ablation. J Androl 2003,24(2),215-225","journal-title":"J Androl"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s004240000476","volume":"441","author":"Shen M-R.","year":"2001","unstructured":"Shen M-R.; Chou C-Y.; Ellory J.C.; Swelling-activated taurine and K+ transport in human cervical cancer cells: Association with cell cycle progression. Pflugers Arch 2001,441(6),787-795","journal-title":"Pflugers Arch"}],"container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/175023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T05:43:40Z","timestamp":1581140620000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/175023\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207322666190920110324","relation":{},"ISSN":["1386-2073"],"issn-type":[{"type":"print","value":"1386-2073"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}