{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:08:36Z","timestamp":1789067316215,"version":"build-2803163510"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2020,5,19]]},"abstract":"<jats:sec>\n<jats:title>Aim and Objective:<\/jats:title>\n<jats:p>This study aimed to investigate the value of Thiol\/Disulfide\nhomeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>This study featured children who were diagnosed with diabetic\nketoacidosis and who were consecutively admitted to pediatric intensive care within one year of\ntheir diagnosis. Thiol\/disulfide homeostasis was evaluated in 45 pediatric patients suffering from\nDKA, as well as 45 healthy controls of parallel gender and age. Thiol\/disulfide homeostasis\nparameters were measured using a novel automated measurement method and the correlation\nbetween demographic data and parameters was measured.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Pediatric patients were found to have low native thiols, total thiols and disulfide levels\nwith type 1 diabetes after DKA (331.82\u00b1106.40, 362.71\u00b1113.31, 17.02\u00b15.33 \u03bcmol\/L, respectively)\nas compared to the control group (445.08\u00b124.41, 481.21\u00b1 28.47, 18.06\u00b15.12 \u03bcmol\/L,\nrespectively).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Thiol\/disulfide homeostasis was distorted in pediatric patients with DKA.\nFurthermore, it was found that they are not likely to return to normal, immediately after treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666200218114331","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T12:43:36Z","timestamp":1582029816000},"page":"185-190","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Thiol\/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis"],"prefix":"10.2174","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-4718","authenticated-orcid":true,"given":"Mutlu U.","family":"Yaz\u0131c\u0131","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-6899","authenticated-orcid":true,"given":"Ganime","family":"Ayar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-2872","authenticated-orcid":true,"given":"Semra","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric, University of Health Sciences, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Endocrinology and Adolescent Clinic, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meliksah","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Pediatric, University of Health Sciences, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Endocrinology and Adolescent Clinic, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-8219","authenticated-orcid":true,"given":"Ebru","family":"Azapa\u011fas\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-5717","authenticated-orcid":true,"given":"Saim","family":"Ne\u015felio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Yildirim Beyazit, Ankara Atat\u00fcrk Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-3236","authenticated-orcid":true,"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Yildirim Beyazit, Ankara Atat\u00fcrk Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benan","family":"Bayrak\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Hacettepe, Pediatric Intensive Care Unit, \u0130hsan Do\u011framac\u0131 Children Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1152\/physrev.00003.2010","volume":"91","author":"van Belle T.L.","year":"2011","unstructured":"van Belle T.L.; Coppieters K.T.; von Herrath M.G.; Type 1 diabetes: etiology, immunology, and therapeutic strategies. 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