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Chimeric chemical structures have been established as an important trend on\nmedicinal chemistry in the last years. Thiazacridines are hybrid molecules composed of a thiazolidine\nand acridine nucleus, both pharmacophores that act on important biological targets for cancer. By the\nfact it is a serious disease, seven new 3-acridin-9-ylmethyl-thiazolidine-2,4-dione derivatives were\nsynthesized, characterized, analyzed by computer simulation and tested in tumor cells. In order to find\nout if the compounds have therapeutic potential.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>Seven new 3-acridin-9-ylmethyl-thiazolidine-2,4-dione derivatives were\nsynthesized through Michael addition and Knoevenagel condensation strategies. Characterization was\nperformed by NMR and Infrared spectroscopy techniques. Regarding biological activity, thiazacridines\nwere tested against solid and hematopoietic tumoral cell lines, namely Jurkat (acute T-cell leukemia);\nHL-60 (acute promyelocytic leukemia); DU 145 (prostate cancer); MOLT-4 (acute lymphoblastic\nleukemia); RAJI (Burkitt's lymphoma); K562 (chronic myelogenous leukemia) and normal cells\nPBMC (healthy volunteers). Molecular docking analysis was also performed in order to assess major\ntargets of these new compounds. Cell cycle and clonogenic assay were also performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Compound LPSF\/AA-62 (9f) exhibited the most potent anticancer activity against HL-60\n(IC50 3,7\u00b11,7 \u03bcM), MOLT-4 (IC50 5,7\u00b11,1 \u03bcM), Jurkat (IC50 18,6 \u03bcM), Du-145 (IC50 20\u00b15 \u03bcM)\nand Raji (IC50 52,3\u00b19,2 \u03bcM). While the compound LPSF\/AA-57 (9b) exhibited anticancer activity\nagainst the K562 cell line (IC50 51,8\u00b17,8 \u03bcM). Derivative LPSF\/AA-62 (9f) did not interfere in the\ncell cycle phases of the Molt-4 lineage. However, the LPSF\/AA-62 (9f) derivative significantly\nreduced the formation of prostate cancer cell clones. The compound LPSF\/AA-62 (9f) has shown\nstrong anchorage stability with enzymes topoisomerases 1 and 2, in particular due the presence of\nchlorine favored hydrogen bonds with topoisomerase 1.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The 3-(acridin-9-ylmethyl)-5-((10-chloroanthracen-9-yl)methylene)thiazolidine-2,4-dione\n(LPSF\/AA-62) presented the most promising results, showing anti-tumor activity in 5 of the 6 cell\ntypes tested, especially inhibiting the formation of colonies of prostate tumor cells (DU-145).<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666200319105239","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:30:26Z","timestamp":1584621026000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives"],"prefix":"10.2174","volume":"23","author":[{"given":"Marcel L.","family":"Almeida","sequence":"first","affiliation":[{"name":"Laboratory of Design and Drug Synthesis (LPSF), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C.F.","family":"Viana","sequence":"additional","affiliation":[{"name":"Laboratory of Design and Drug Synthesis (LPSF), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9cia C.M.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviana A.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelly C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maira G.R.","family":"Pitta","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moacyr J.B.","family":"de Melo R\u00eago","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan R.","family":"Pitta","sequence":"additional","affiliation":[{"name":"Laboratory of Design and Drug Synthesis (LPSF), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina G.R.","family":"Pitta","sequence":"additional","affiliation":[{"name":"Laboratory of Design and Drug Synthesis (LPSF), Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Biosciences Center, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2174\/1874844901805010012","volume":"5","author":"Mali S.N.","year":"2018","unstructured":"Mali S.N.; Chaudhari H.K.; Computational studies on imidazo [1,2-a] pyridine-3-carboxamide analogues as antimycobacterial agents: common pharmacophore generation, atom-based 3DQSAR, molecular dynamics simulation, qikprop, molecular docking and prime MMGBSA approaches. 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