{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:10:58Z","timestamp":1758892258942,"version":"3.37.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"6","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Scientific Foundation of China","doi-asserted-by":"publisher","award":["61702430"],"award-info":[{"award-number":["61702430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2020,10,5]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>RNA methylation is a reversible post-transcriptional modification\ninvolving numerous biological processes. Ribose 2'-O-methylation is part of RNA methylation. It\nhas shown that ribose 2'-O-methylation plays an important role in immune recognition and other\npathogenesis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> We aim to design a computational method to identify 2'-O-methylation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Different from the experimental method, we propose a computational workflow to\nidentify the methylation site based on the multi-feature extracting algorithm.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>With a voting procedure based on 7 best feature-classifier combinations, we achieved\nAccuracy of 76.5% in 10-fold cross-validation. Furthermore, we optimized features and input the\noptimized features into SVM. As a result, the AUC reached to 0.813.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The RNA sample, especially the negative samples, used in this study are more\nobjective and strict, so we obtained more representative results than state-of-arts studies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666200425210609","type":"journal-article","created":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T06:34:36Z","timestamp":1587882876000},"page":"527-535","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of 2\u2019-O-methylation Site by Investigating Multi-feature Extracting Techniques"],"prefix":"10.2174","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-8731","authenticated-orcid":true,"given":"Qin-Lai","family":"Huang","sequence":"first","affiliation":[{"name":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5353-1620","authenticated-orcid":true,"given":"Lida","family":"Wang","sequence":"additional","affiliation":[{"name":"Scientific Research Department, Heilongjiang Agricutural Recalmation General Hospital, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1153-9306","authenticated-orcid":true,"given":"Shu-Guang","family":"Han","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-4544","authenticated-orcid":true,"given":"Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/181326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T18:23:47Z","timestamp":1606587827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/181326\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,10,5]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666200425210609","relation":{},"ISSN":["1386-2073"],"issn-type":[{"type":"print","value":"1386-2073"}],"subject":[],"published":{"date-parts":[[2020,10,5]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}