{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:41:34Z","timestamp":1772109694673,"version":"3.50.1"},"reference-count":42,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Hydrocephalus, a common brain disorder in children, can cause\npermanent brain damage. A timely diagnosis of this disorder is crucial.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of this study was to evaluate the levels of S-100, CK-18, and NSE brainspecific\nproteins in patients with hydrocephalus. We examined the levels of these proteins in the\nblood samples of hydrocephalic patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> The study was conducted on the hydrocephalus (n = 31) patients and a healthy control\ngroup (n = 30). A Receiver Operating Characteristic (ROC) curve was used to assess the validity of\nthe NSE, CK-18, and S100B to differentiate between the hydrocephalus and the control groups.\nThe suitability of the data to the normal distribution was tested with the Shapiro Wilk test, and the\nStudent t-test was used to compare the characteristics of the normal distribution in two independent\ngroups. The individuals in the hydrocephalus and control groups had similar values in terms of age,\nheight, and weight.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>It was observed that NSE, CK-18, and S100B mean values of the individuals in the\nhydrocephalus group were significantly higher than NSE, CK-18, and S100B mean values of the\ncontrol group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Experiments have shown that the levels of these proteins increase significantly in\nhydrocephalus patients compared to the healthy group. These three parameters can be considered\nas important markers in the diagnosis of hydrocephalus.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666200720093245","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T09:13:11Z","timestamp":1595322791000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients"],"prefix":"10.2174","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-3957","authenticated-orcid":true,"given":"Ahmet","family":"Guzelcicek","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-1537","authenticated-orcid":true,"given":"Ataman","family":"G\u00f6nel","sequence":"additional","affiliation":[{"name":"Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4757","authenticated-orcid":true,"given":"Ismail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Biochemistry, Faculty of Medicine, Harran University, Sanliurfa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-1172","authenticated-orcid":true,"given":"Gulyara","family":"Cigdem","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Harran University, Sanliurfa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-2976","authenticated-orcid":true,"given":"Dogan","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-4193","authenticated-orcid":true,"given":"Mehmet","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mustafa Kemal University, Faculty of Medicine, Hatay,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-382X","authenticated-orcid":true,"given":"Dursun","family":"Cadirci","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Harran University, Sanliurfa,Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00701-002-1019-1","volume":"145","author":"Beems T.","year":"2003","unstructured":"Beems T.; Simons K.S.; Van Geel W.J.; De Reus H.P.; Vos P.E.; Verbeek M.M.; Serum- and CSF-concentrations of brain specific proteins in hydrocephalus. 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