{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:43:25Z","timestamp":1787024605282,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Eimeriosis is a parasitic intestinal infection that affects the poultry industry;\nit is responsible for economic losses on a global scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigated the protective role of Morus nigra leaf extracts (ME) against Eimeria papillata infection\nin mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>C57Bl\/6 mice were divided into six groups. The first group was gavaged daily with 100\n\u03bcL 0.9% NaCl. The second group was treated daily by oral gavage with 100 \u03bcL M. nigra leaf extracts\n(ME) (200 mg\/kg), while the third, fourth, fifth, and sixth groups were orally infected with\n1000 E. papillata oocysts. The last three groups were daily treated for 5 days with 200, 400, and\n800 mg\/kg of ME, respectively. Samples of jejunum were obtained for examining the histopathological\nchanges as well as changes in the nitric oxide and catalase levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Infrared spectroscopy of ME showed the presence of several expected active classes of\nphytochemical compounds. ME was able to reduce the E. papillata oocysts in mice feces by about\n80% and decrease the infection-induced jejunal histopathological injuries. This was quantified using\nthe histological injury score. In addition, ME significantly recovered the changes in nitric oxide\nand catalase levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings showed that the M. nigra extract has an antioxidant activity which protects\nagainst murine eimeriosis. Further studies are required to determine the exact active compounds\nin ME and their mode of action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1386207323666200903152811","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T07:38:55Z","timestamp":1599205135000},"page":"1603-1608","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective Role of Morus nigra Leaf Extracts against Murine Infection with Eimeria papillata"],"prefix":"10.2174","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-2463","authenticated-orcid":true,"given":"Felwa A.","family":"Thagfan","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa A.","family":"Al-Megrin","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-4802","authenticated-orcid":true,"given":"Esam M.","family":"Al-Shaebi","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-3124","authenticated-orcid":true,"given":"Saleh","family":"Al-Quraishy","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-5800","authenticated-orcid":true,"given":"Mohamed A.","family":"Dkhil","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185545\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T08:58:52Z","timestamp":1631696332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185545\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9,14]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666200903152811","relation":{},"ISSN":["1386-2073"],"issn-type":[{"value":"1386-2073","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}