{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:06:15Z","timestamp":1793383575892,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,6,29]]},"abstract":"<jats:sec>\n<jats:title>Background\/Aims:<\/jats:title>\n<jats:p>This study aimed to ascertain the effects of astaxanthin on the lungs\nof rat pups with bronchopulmonary dysplasia (BPD) induced by hyperoxia and lipopolysaccharide\n(LPS).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>Forty-two newborn Wistar rats, born to spontaneous pregnant rats, were\ndivided into three groups: Hyperoxia (95% O2) + lipopolysaccharide (LPS) group, hyperoxia +\nLPS + astaxhantin group, and control: no treatment group (21% O2). Pups in the hyperoxia + LPS\n+ astaxanthin group were given 100 mg\/kg\/day oral astaxanthin from the first day to the fifth day.\nHistopathologic and biochemical evaluations, including glutathione (GSH), total anti-oxidant status\n(TAS), total oxidant status (TOS), lipid hydroperoxide (LPO), 8-hydroxydeoxyguanosine (8-OHdG),\nadvanced oxidation protein products (AOPP), myeloperoxidase (MPO), total thiol, tumor necrosis\nfactor-alpha (TNF-\u03b1), interleukin 1 beta (IL-1\u03b2), and caspase-3 activities, were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Better survival rates and weight gain were demonstrated in the hyperoxia + LPS + astaxanthin\ngroup (p &lt;0.001). In the histopathologic evaluation, the severity of lung damage was significantly\nreduced in the hyperoxia+LPS+astaxanthin group, as well as decreased apoptosis (EL\u0130SA\nfor caspase-3) (p &lt;0.001). The biochemical analyses of lung tissues showed that TAS, GSH, and\nTotal thiol levels were significantly higher in the astaxanthin treated group compared to the hyperoxia\n+ LPS group (p &lt;0.05) while TOS, AOPP, LPO, 8-OHdG, MPO levels were significantly lower\n(p &lt;0.001). In addition, unlike the hyperoxia + LPS group, TNF-\u03b1 and IL-1\u03b2 levels in lung tissue\nwere significantly lower in the astaxanthin-treated group (p &lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Astaxanthin was shown to reduce lung damage caused by inflammation and hyperoxia\nwith its anti-inflammatory, anti-oxidant, anti-apoptotic properties, and to protect the lung from\nsevere destruction.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666200915092012","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T04:06:39Z","timestamp":1600229199000},"page":"1243-1250","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Astaxanthin Prevents Lung Injury Due to Hyperoxia and Inflammation"],"prefix":"10.2174","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-1496","authenticated-orcid":true,"given":"Hasan","family":"Akduman","sequence":"first","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9970-0714","authenticated-orcid":true,"given":"C\u00fcneyt","family":"Tayman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Republic of Turkey Ministry of Health, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-185X","authenticated-orcid":true,"given":"Ufuk","family":"\u00c7akir","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Republic of Turkey Ministry of Health, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-5744","authenticated-orcid":true,"given":"Esra","family":"\u00c7akir","sequence":"additional","affiliation":[{"name":"Department Anesthesiology and Clinical of Critical Care, Republic of Turkey Ministry of Health, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-2562","authenticated-orcid":true,"given":"Dilek","family":"Dilli","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-2928","authenticated-orcid":true,"given":"Tu\u011fba Ta\u015fkin","family":"T\u00fcrkmeno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-1537","authenticated-orcid":true,"given":"Ataman","family":"G\u00f6nel","sequence":"additional","affiliation":[{"name":"Department of Medicinal Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185905\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T06:37:48Z","timestamp":1625121468000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185905\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,6,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666200915092012","relation":{},"ISSN":["1386-2073"],"issn-type":[{"value":"1386-2073","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}