{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:38:26Z","timestamp":1772800706655,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:sec>\n<jats:title>Aim and Objective:<\/jats:title>\n<jats:p>In the current study, environmentally benign and cost-effective\nprocedures were suggested for the preparation of carboxy group functionalized imidazolium salts,\nincluding [Cmmim]BF<jats:sub>4<\/jats:sub>\n- or [Cmmim]Br- as a new, reusable Br\u00f8nsted acidic ionic liquid (BAIL)\ncatalyst. Then, the catalytic performance of [Cmmim]BF<jats:sub>4<\/jats:sub>\n- or [Cmmim]Br- were successfully\ninspected towards the three-components one pot preparation of pyrano[2,3-d]pyrimidinone\nderivatives 4a-4q. The mentioned procedures show short reaction times, easy work-up procedure,\ngreen conditions, high yields of the products, high potent of recovering, and reusing capability. The\ncurrent study is useful and adequate for the application and development of imidazolium salts on\nthe basis of green chemistry principles.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>An aromatic aldehyde (1 mmol), barbituric acid (1 mmol), and\nmalononitrile (1 mmol) were placed in a round-bottomed flask containing ethanol (5 mL). BAILs\nA and B (0.1 mmol, 10 mol%) were added to the mixture. The suspension was magnetically stirred\nat room temperature for an appropriate time (Table 2). After completion of the reaction, which was\nmonitored by TLC (n-hexane:ethyl acetate = 3:1), the pure product was filtered off to separate the\ncatalyst, washed with water, and recrystallized from ethanol to afford the pure compound. After\nseparation of the product, the catalyst was recovered by evaporation of water, washed with Et<jats:sub>2<\/jats:sub>O,\ndried under vacuum for 2 h, and reused for the same reaction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The mentioned procedure shows short reaction times, easy work-up procedure, green\nconditions, high yields of the products, and high potent of recovering and reusing capability.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this study, we unveiled the synthesis of a new acetic acid functionalized ionic\nliquids [Cmmim]BF<jats:sub>4<\/jats:sub>\n- BAIL A or [Cmmim]Br- BAIL B and their application for the preparation of\npyrano[2,3-d]pyrimidinone derivatives via a three-component reaction among various aromatic\naldehydes, barbituric acid, and malononitrile under mild and metal-free conditions. A wide range\nof pyrano[2,3-d]pyrimidinone derivatives bearing diverse functional groups was obtained in short\nreaction and excellent yields. Operational simplicity, recoverability, and reusability of catalysts,\ncheap and chemically stable reagents, high catalytic activity, easy work-up, and the eco-friendly\nprocedure, make this method environmentally benign and cost-effective.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666201007154343","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:18:43Z","timestamp":1602148723000},"page":"1465-1475","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Highly Efficient Reusable Carboxy Group Functionalized Imidazolium Salts for a Simple and Cost-effective Preparation of pyrano[2,3-d]pyrimidinone Derivatives"],"prefix":"10.2174","volume":"24","author":[{"given":"Elham","family":"Ezzatzadeh","sequence":"first","affiliation":[{"name":"Department of Chemistry, Ardabil Branch, Islamic Azad University, Ardabil, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Sheikholeslami-Farahani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Firoozkooh Branch, Islamic Azad University, Firoozkooh, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijeh","family":"Yadollahzadeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sobhan","family":"Rezayati","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Payame Noor University, PO BOX 19395- 4697 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186722\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:52:05Z","timestamp":1628149925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186722\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666201007154343","relation":{},"ISSN":["1386-2073"],"issn-type":[{"value":"1386-2073","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}