{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:11:53Z","timestamp":1789693913060,"version":"4.0.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","funder":[{"DOI":"10.13039\/501100011501","name":"Science and Technology Support Program of Qinghai","doi-asserted-by":"publisher","award":["2020-ZJ-Y40"],"award-info":[{"award-number":["2020-ZJ-Y40"]}],"id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:sec>\n<jats:title>Background and Objective:<\/jats:title>\n<jats:p>A Tibetan traditional herb named Swertia mussotii Franch.,\nalso called \u201cZangyinchen\u201d by the local people of the Qinghai-Tibet area, has been used to protect\nthe liver from injury for many years. However, the curative effect and molecular mechanism of the\nherb have not been demonstrated clearly.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p> In our study, serum alanine aminotransferase, aspartate aminotransferase,\nand total bilirubin levels were examined after S. mussotii Franch. treatment of the acute liver injury\non the carbon tetrachloride-induced rat model. Then, proteome analysis was conducted to explore\nthe potential mechanism of SMT for hepatoprotective effects after iTRAQLC-MS\/MS analysis\n(isobaric tag for relative and absolute quantification-liquid chromatography-mass spectrometer\nwith tandem mass spectrometry).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Serum results showed that alanine aminotransferase, aspartate aminotransferase, and total\nbilirubin levels of rats with acute liver injury were all improved with SMT treatment. Moreover,\nproteome analysis suggested that, with S. mussotii Franch. treatment, the levels of lipid catabolic\nprocess and lipid homeostasis were all enhanced. Furthermore, the results of protein-protein\ninteraction (PPI) analysis illustrated that the proteins assembled in PPI networks were found to be\nsignificantly enriched in response to lipid, negative regulation of lipase activity, and in response to\nlipopolysaccharides. Furthermore, the down-regulated MRP14 and MRP8 proteins were found to\nbe involved in the lipid metabolism, which may indicate the mechanism of SMT for the protection\nof the liver from ALI induced by carbon tetrachloride.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>SMT herb could play a role in hepatoprotection and alleviating the acute liver injury\nby impacting the lipid metabolism associated with the biological process.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666201020111301","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T07:30:41Z","timestamp":1603265441000},"page":"1332-1339","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Mechanism of Swertia mussotii Franch. for Hepatoprotective Effects with iTRAQ LC-MS\/MS"],"prefix":"10.2174","volume":"24","author":[{"given":"Haixia","family":"Yun","sequence":"first","affiliation":[{"name":"Medical College of Qinghai University, Xining 810001, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Animal and Plant Resources of the Qinghai-Tibetan Plateau, School of Life Science, Qinghai Normal University, Xining 810008, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Animal and Plant Resources of the Qinghai-Tibetan Plateau, School of Life Science, Qinghai Normal University, Xining 810008, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendou","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Animal and Plant Resources of the Qinghai-Tibetan Plateau, School of Life Science, Qinghai Normal University, Xining 810008, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglan","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Animal and Plant Resources of the Qinghai-Tibetan Plateau, School of Life Science, Qinghai Normal University, Xining 810008, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical College of Qinghai University, Xining 810001, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical College of Qinghai University, Xining 810001, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Animal and Plant Resources of the Qinghai-Tibetan Plateau, School of Life Science, Qinghai Normal University, Xining 810008, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186986\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:51:48Z","timestamp":1628149908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186986\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666201020111301","relation":{},"ISSN":["1386-2073"],"issn-type":[{"value":"1386-2073","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}