{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:45:52Z","timestamp":1775245552093,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:sec>\n<jats:title>Background and Objective:<\/jats:title>\n<jats:p>Perimenopause is a physiological occurrence in women,\nand is characterized by endocrine and biochemical changes. During perimenopause phase, many\nderangements or abnormal health conditions start developing as a result of hormonal changes.\nThese derangements in health conditions and biochemical changes lead to higher incidence of\nmetabolic syndrome (MetS) occurrence with or without bone involvement. There is a scarcity of\ninformation on MetS in Enugu, Southern Nigeria and there is no available data on the correlation\nof selected bone-related biochemicals with endocrine parameters and MetS in perimenopausal\nwomen from the region.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p> We consecutively sampled 200 apparently healthy women, and\ncategorized them into 120 perimenopausal women (age (x) = 50years) and a second group of 80\nwomen in premenopause (age (x) = 35years). Measurement of anthropometric indices like blood\npressure, height, weight and waist circumference were taken. Fasting blood samples were collected\nfor the estimation of endocrine parameters (estradiol (E<jats:sub>2<\/jats:sub>), follicle stimulating hormone (FSH), and\nluteinizing hormone (LH)) using enzyme linked immunosorbent assay (ELISA) technique. The\nlipid profile, fasting plasma glucose (FPG), uric acid, inorganic phosphate, calcium and alkaline\nphosphatase levels were determined using standard biochemical methods. The evaluation of MetS\nwas carried out in the women using the three different criteria: World Health Organization (WHO),\nNational Cholesterol Education Program- Adult Treatment Panel 111 (NCEP-ATP 111) and\nInternational Diabetes Federation (IDF). For statistical analysis, Student\u2019s t-test, Pearson\ncorrelation and Chi-square were used to compare categorical and continuous variables.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Calcium was predominantly high in the three criteria (p&lt;0.05). LH and FSH showed a\npositive correlation with FPG while E<jats:sub>2<\/jats:sub> was negatively associated with FPG. Similarly, LH showed\na positive association with inorganic phosphate while E<jats:sub>2<\/jats:sub> was negatively associated with alkaline\nphosphatase (p&lt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Perimenopausal women are at higher risk of developing osteoporosis than\npremenopausal women. This emphasizes the need for timely diagnosis of osteoporosis in\nperimenopausal women.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666201023120212","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T04:06:02Z","timestamp":1603685162000},"page":"1492-1502","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlative Study of Bone-related Biochemicals and Endocrine Changes in Perimenopausal Women in Enugu, Nigeria"],"prefix":"10.2174","volume":"24","author":[{"given":"Chinwe Ifeoma","family":"Ikegwuonu","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-3759","authenticated-orcid":true,"given":"Ikenna Kingsley","family":"Uchendu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chukwudi Ignatius","family":"Maduka","sequence":"additional","affiliation":[{"name":"Department of Human Biochemistry, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/187146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/187146\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/187146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:52:10Z","timestamp":1628149930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/187146\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666201023120212","relation":{},"ISSN":["1386-2073"],"issn-type":[{"value":"1386-2073","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}