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However, the\npathogenesis of OA is still unclear, which leads to limited treatment and the therapeutic effect far\nfrom people's expectations. This study aims to filter out key genes in the pathogenesis of OA and\nexplore their potential role in the occurrence and development of OA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The dataset of GSE117999 was obtained and analyzed in order to identify the\ndifferentially expressed genes (DEGs), hub genes and key genes. We also identified potential\nmiRNAs which may play a major role in the pathogenesis of OA, and verified their difference in\nOA by real-time quantitative PCR (RT-qPCR). DGldb was found to serve as an indicator to\nidentify drugs with potential therapeutic effects on key genes and Receiver Operating\nCharacteristic (ROC) analysis was used for identifying underlying biomarkers of OA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We identified ten key genes, including MDM2, RB1, EGFR, ESR1, UBE2E3, WWP1,\nBCL2, OAS2, TYMS and MSH2. Then, we identified hsa-mir-3613-3p, hsa-mir-548e-5p and hsamir-\n5692a to be potentially related to key genes. In addition, RT-qPCR confirmed the differential\nexpression of identified genes in mouse cartilage with or without OA. We then identified\nEtoposide and Everolimus, which were potentially specific to the most key genes. Finally, we\nspeculated that ESR1 might be a potential biomarker of OA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>In this study, potential key genes related to OA and their biological functions were\nidentified, and their potential application value in the diagnosis and treatment of OA has been\ndemonstrated, which will help us to improve the therapeutic effect of OA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666201207100905","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T05:31:33Z","timestamp":1607405493000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Mystery of Osteoarthritis using Bioinformatics Analysis of Cartilage Tissue"],"prefix":"10.2174","volume":"25","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Long","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-543X","authenticated-orcid":true,"given":"Hua-Ding","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong,China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/17453674.2017.1404791","volume":"89","author":"Kiadaliri A.A.","year":"2018","unstructured":"Kiadaliri A.A.; Lohmander L.S.; Moradi-Lakeh M.; Petersson I.F.; Englund M.; High and rising burden of hip and knee osteoarthritis in the Nordic region, 1990-2015. 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