{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:44:48Z","timestamp":1787060688891,"version":"build-2736575974"},"reference-count":33,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>It has been reported that glial cells are involved in Alzheimer\u2019s disease (AD). According to our previous\nresearch, Scutellaria barbata flavonoids (SBFs) can protect the neuronal disorder and memory impairment for AD-like rats,\nwhile the effect of SBFs on the glial cells disorder in AD-like rats has been less well studied. The effects of SBFs on\nastrocytes(ASs), microglial cells (MGs) and oligodendrocytes (Ols), as well as heat shock proteins 70 (Hsp70) and\napolipoprotein E (ApoE) were investigated in the present study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The successful model rats, screened by Morris water maze, were daily orally administrated with 35, 70 and 140\nmg\/kg SBFs for 36 d. The numbers of brain\u2019s astrocytes (ASs), microglial cells (MGs) and oligodendrocytes (Ols) were\nexamined by immunohistochemistry. The cortical glial fibrillary acidic protein (GFAP), leukocyte common antigen (LCA)\n(CD45), Claudin 11 and heat shock proteins 70 (Hsp70) protein expression were assayed by Western blotting, and\napolipoprotein E (ApoE) mRNA expression was analyzed by real-time quantitative polymerase chain reaction (qPCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared with the sham-operated group, the number of ASs and MGs in the brain was\nsignificantly increased in the model group (P&lt;0.05, P&lt;0.01), accompanied by an increase in the\nexpressions of GFAP, CD45, Hsp70 protein, and ApoE mRNA (P&lt;0.05, P&lt;0.01). Both Ols\nnumber and the expression of Claudin 11 protein decreased in the brain in the model group\n(P&lt;0.05, P&lt;0.01). However, the above-mentioned abnormal changes induced by composited A\u03b2\nwere differently reversed by the treatment of SBFs at three doses of 35, 70, and 140 mg\/kg\n(P&lt;0.05, P&lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SBFs can dramatically improve the abnormal changes in glial cells of the brains of\nrats, induced by composited A\u03b2, which may be utilized as a helpful treatment for\nneurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1386207323666201209092358","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T23:44:11Z","timestamp":1607557451000},"page":"64-76","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Scutellaria barbata Flavonoids Improve the Composited A\u03b2-induced Abnormal Changes in Glial Cells of the Brains of Rats"],"prefix":"10.2174","volume":"25","author":[{"given":"Jian-Jun","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei 067000,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Guo","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Guang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei 067000,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"MA","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei 067000,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei 067000,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Ya-Zhen","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine, Chengde Medical College, Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei 067000,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/msj.20157","volume":"77","author":"Perl D.P.","year":"2010","unstructured":"Perl D.P.; Neuropathology of Alzheimer\u2019s disease. 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