{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:28Z","timestamp":1790116108785,"version":"4.0.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP-2020\/225"],"award-info":[{"award-number":["RSP-2020\/225"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Hepatotoxicity remains an important clinical challenge. Hepatotoxicity\nobserved in response to toxins and hazardous chemicals may be alleviated by delivery of the\ncurcumin in silver nanoparticles (AgNPs-curcumin). In this study, we examined the impact of\nAgNPs-curcumin in a mouse model of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced hepatic injury.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Male C57BL\/6 mice were divided into three groups (n=8 per group). Mice in group 1\nwere treated with vehicle control alone, while mice in Group 2 received a single intraperitoneal\ninjection of 1 ml\/kg CCl4 in liquid paraffin (1:1 v\/v). Mice in group 3 were treated with 2.5 mg\/kg\nAgNPs-curcumin twice per week for three weeks after the CCl<jats:sub>4<\/jats:sub> challenge.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Administration of CCL<jats:sub>4<\/jats:sub> resulted in oxidative dysregulation, including significant\nreductions in reduced glutathione and concomitant elevations in the level of malondialdehyde\n(MDA). CCL<jats:sub>4<\/jats:sub> challenge also resulted in elevated levels of serum aspartate transaminase (AST)\nand alanine transaminase (ALT); these findings were associated with the destruction of hepatic\ntissues. Treatment with AgNPs-curcumin prevented oxidative imbalance, hepatic dysfunction, and\ntissue destruction. A comet assay revealed that the CCl<jats:sub>4<\/jats:sub> challenge resulted in significant DNA\ndamage as documented by a 70% increase in nuclear DNA tail-length; treatment with AgNPscurcumin\ninhibited the CCL4-mediated increase in nuclear DNA tail-length by 34%.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Administration of AgNPs-curcumin resulted in significant anti-oxidant activity in\nvivo. This agent has the potential to prevent hepatic tissue destruction and DNA damage that\nresults from direct exposure to CCL<jats:sub>4<\/jats:sub>.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207323666201211100830","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T08:06:53Z","timestamp":1607933213000},"page":"1609-1617","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Curcumin-containing Silver Nanoparticles Prevent Carbon Tetrachloride- induced Hepatotoxicity in Mice"],"prefix":"10.2174","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-7820","authenticated-orcid":true,"given":"Hossam","family":"Ebaid","sequence":"first","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P. O. Box 62521, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Habila","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftekhar","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P. O. Box 62521, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameel","family":"Al-Tamimi","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P. O. Box 62521, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Benha University, 13508 Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Rady","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P. O. Box 62521, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M","family":"Alhazza","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P. O. Box 62521, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189044\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:58:54Z","timestamp":1631710734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189044\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9,14]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666201211100830","relation":{},"ISSN":["1386-2073"],"issn-type":[{"value":"1386-2073","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}