{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:15:42Z","timestamp":1790770542980,"version":"4.1.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"11","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Melanogenesis is simply defined as the production of melanin in melanosomes by melanocytes\nthrough a complex process. Melanin, a pigment derived from L-tyrosine, comes into two\nforms, namely eumelanin (brownish to black) and pheomelanin (red to yellow). Melanin synthesis\nstarts via the hydroxylation of L-tyrosine to L-3,4-Dihydroxyphenylalanine (DOPA) catalyzed by\nthe enzyme known as Tyrosinase (TYR), which triggers further conversion reaction to DOPAquinone\nand then to DOPAchrome. Additionally, this process is also related to two more proteins, i.e.,\noxygenase TYR-related Protein 1 (TYRP1), and Dopachrome Tautomerase TYRP2 (or DCT).\nHowever, TYR located in the melanosomal membrane still stands as the key enzyme to initiate the\nwhole process of melanogenesis. Due to some deficits, melanogenesis may emerge as hypo- or hyperpigmentation\nin the skin. High production of melanin in melanocytes leads to hyperpigmentation-\nrelated skin disorders, including freckles, melasma, melanoma, etc., that may cause displeasure\nin personal appearance and reduce quality of life. Consequently, several melanogenesis inhibitors of\nsynthetic and natural origins have been developed up to date, though most of them have been reported\nwith serious side effects. For this reason, extensive research is still going on to find novel and\nmore effective melanogenesis inhibitors with less side effects. In this sense, particularly flavonoids,\ncatechins, and stilbenes from plants have been a hope to discover new inhibitors which gain significant\nattention from scientists. In this review, promising natural products effective in melanogenesis\ninhibition will be scrutinized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1386207323666201211102233","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T03:06:53Z","timestamp":1607915213000},"page":"1412-1423","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Inhibition of Melanogenesis by Some Well-Known Polyphenolics: A Review"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-5436","authenticated-orcid":true,"given":"Ilkay E.","family":"Orhan","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma S.S.","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189046\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:45:08Z","timestamp":1628599508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189046\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1386207323666201211102233","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}