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It catalyzed different asymmetric\nsyntheses, including known reactions such as Aldol condensation, Mannich reaction, Michael\nAddition, Knoevenagel condensation, Hantzsch synthesis, OXA-Michael Henry tandem,\nUllmann reactions, Wieland-Miescher ketone synthesis, Robinson annulation, Biginelli reaction, \u03b1-\namination. It is also an essential catalyst for synthesizing heterocyclic skeletons such as coumarin,\nspiro-oxindoles, imidazoles, benzimidazoles, quinoxalines, podophyllotoxin, benzothiazoles, isoxazolidines,\nphenothiazines, aziridine, indole, 1,5-benzodiazepines, pyridine, and quinazolines.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>In this review, we had the objective to critically summarize the use of proline and proline\nderivatives as catalysts of multicomponent reactions performed in various media and leading\nto synthetically and biologically relevant heterocycles, a very important class of compounds that\nconstitutes over 60% of drugs and agrochemicals.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>All scholarly articles for L-Proline catalyzed reactions were retrieved from ScienceDirect,\nGoogle Scholar , PubMed, etc.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results and Conclusion:<\/jats:title>\n<jats:p>Given the importance of L-Proline based reactions, it has been observed\nto have tremendous applications in organic chemistry. It can also act as a 'Green catalyst'.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207325666220720105845","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T05:55:19Z","timestamp":1658469319000},"page":"1108-1140","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["L-Proline: A Versatile Organo-Catalyst in Organic Chemistry"],"prefix":"10.2174","volume":"26","author":[{"given":"Bapu R.","family":"Thorat","sequence":"first","affiliation":[{"name":"Government of Maharashtra, Government College of Arts and Science, Aurangabad 431001 (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-136X","authenticated-orcid":true,"given":"Suraj N.","family":"Mali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati S.","family":"Wavhal","sequence":"additional","affiliation":[{"name":"Department of Chemistry,\nGovernment of Maharashtra\u2019s Ismail Yusuf College of Arts, Science and Commerce, Mumbai 410060 (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devidas S.","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government Institute of Forensic Science, Aurangabad 431 004, (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikumar M.","family":"Borade","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government Institute of Forensic Science, Aurangabad 431 004, (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chapolikar","sequence":"additional","affiliation":[{"name":"Government of Maharashtra, Government College of Arts and Science, Aurangabad 431001 (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajaykumar","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Government of Maharashtra, Government College of Arts and Science, Aurangabad 431001 (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"Shinde","sequence":"additional","affiliation":[{"name":"Government of Maharashtra, Government College of Arts and Science, Aurangabad 431001 (MS), India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","DOI":"10.1002\/3527604677","author":"Berkessel A.","year":"2005","unstructured":"Berkessel A.; Gr\u00f6ger H.;  Asymmetric organocatalysis 2005","journal-title":"Asymmetric organocatalysis"},{"key":"ref=1d","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1055\/s-2001-18074","author":"List B.","year":"2001","unstructured":"List B.; Asymmetric aminocatalysis. 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