{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:49:16Z","timestamp":1757450956709,"version":"3.37.3"},"reference-count":72,"publisher":"Bentham Science Publishers Ltd.","issue":"8","funder":[{"DOI":"10.13039\/501100009991","name":"Jilin Provincial Department of Finance Science and Technology Project","doi-asserted-by":"publisher","award":["2021893-9"],"award-info":[{"award-number":["2021893-9"]}],"id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Provincial Development and Reform Commission 2021 Industrial Technology Research and Development Project","doi-asserted-by":"publisher","award":["2021C043-2"],"award-info":[{"award-number":["2021C043-2"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory\nsyndrome coronavirus 2 (SARS-CoV-2), has a serious threat to human health. Oral candidiasis\n(OC) may be one of the causes of morbidity in severe COVID-19 patients. However, there is currently\nno treatment for oral candidiasis and COVID-19 (OC\/COVID-19). The purpose of this study\nwas to use text mining and data analysis to investigate the target genes for treatment and explore\npotential therapeutic drugs for OC\/COVID-19.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We used the text mining tool pubmed2ensembl to detect genes associated with OC, and\nthe dataset GSE164805 was used for the data analysis. Then, Gene Ontology (GO) and Kyoto Encyclopedia\nof Genes and Genomes (KEGG) analyses were performed on two intersection genes using\nthe Database of Annotation, Visualization and Integrated Discovery (DAVID) platform. The\nprotein-protein interaction (PPI) networks were constructed by STRING software, and gene module\nanalysis was performed using Molecular Complex Detection (MCODE), a plug-in in Cytoscape.\nThe most significant genes were selected as hub genes and their functions and pathways\nwere analyzed using Metascape. We revealed the upstream pathway activity of the hub genes. The\ndrug-gene interaction database (DGIdb) and the traditional Chinese medicines integrated database\n(TCMID) were used to discover potential drugs for the treatment of OC\/COVID-19.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The analysis indicated that there were 2869 differentially expressed genes (DEGs) in\nGSE164805. We identified 161 unique genes associated with oral candidiasis through text mining.\nA total of 20 intersection genes were identified as the therapeutic targets for OC\/COVID-19. Based\non the bioinformatics analysis, nine genes (TNF, IL1B, IFNG, CSF2, ELANE, CCL2, MMP9,\nCXCR4, and IL1A) were identified as hub genes that were mainly enriched in the IL-17 signaling\npathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications and\nNOD-like receptor signaling pathway. We identified four of the nine genes that target five existing\ndrugs, including BKT140, mavorixafor, sivelestat, canakinumab, and rilonacept. Furthermore,\ntwenty herb ingredients were also screened as potential drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this study, TNF, IL1B, IFNG, CSF2, ELANE, CCL2, MMP9, CXCR4, and IL1A\nwere potentially key genes involved in the treatment of OC\/COVID-19. Taken together five drugs\nand twenty herb ingredients were identified as potential therapeutic agents for OC\/COVID-19\ntreatment and management.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207325666221007111239","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T04:57:01Z","timestamp":1665377821000},"page":"1533-1546","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioinformatics Analysis to Identify Intersection Genes, Associated Pathways\nand Therapeutic Drugs between COVID-19 and Oral Candidiasis"],"prefix":"10.2174","volume":"26","author":[{"given":"Liuqing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinling","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","volume":"5","year":"2020","unstructured":"Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. 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