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Shuangshi Tonglin Capsule\n(SSTLC) is a clinical drug for the treatment of chronic prostatitis. However, the underlying molecular\nmechanisms of SSTLC in treating CP are still unclear. In this study, we researched the underlying\nmechanisms of SSTLC in treating chronic prostatitis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The ingredients of SSTLC were received from the TCMSP and BATMAN databases,\nand the CP targets were collected based on GeneCards and OMIM. Then, the PPI network and the\n\u201cdrug-ingredient-target\u201d network map were constructed. GO and KEGG enrichment analyses by\nusing DAVID. Molecular docking was performed by using AutoDock 4.2 and PyMol. And using\nanimal experiments to verify the potential effect of SSTLC in CP.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>SSTLC contained 10 herbs, 158 chemical ingredients and 277 targets, 2002, diseaserelated\ntargets were obtained. Network analysis outcomes indicated that VEGFA, TNF, MAPK1,\nEGFR, and MAPK8 are the key targets of SSTLC in treating chronic prostatitis. Furthermore, molecular\ndocking revealed that quercetin, luteolin, and kaempferol exhibited a strong binding effect.\nAnimal experimental indicated that SSTLC can reduce the pathological damage to prostate tissue.\nAnd, we found that high-dose SSTLC significantly reduced the level of TNF-\u03b1 and downregulated\nthe expression of EGFR, p-p38 and p-ERK1\/2 (P&lt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>This study determined the pharmacological effects of SSTLC and the potential mechanism\nof action on SSTLC to treat CP, it provides a new idea for traditional Chinese medicine to\ntreat chronic prostatitis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207326666221024144543","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:30:15Z","timestamp":1666758615000},"page":"1856-1865","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Network Pharmacology and Experimental Verification to\nInvestigate the Mechanisms of Shuangshi Tonglin Capsule to Treat Chronic\nProstatitis"],"prefix":"10.2174","volume":"26","author":[{"given":"Qian","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiping","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of\nTechnology, Shaanxi Momentum Pharmaceutical Co., Ltd. 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