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ALI may be treated by reducing\ninflammation. Fat emulsion is used in parenteral nutrition for critically ill patients to regulate\nthe body's inflammatory response. It is mostly made up of \u03c9-9 MUFAs (Clinoleic), which can\nregulate the inflammatory response.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The effect of \u03c9-9MUFAs on the secretion of IL-6 in ALI rats was studied in order to\nprovide a basis for the rational use of fat emulsion in clinical practice and provide new ideas for the\ndiagnosis and treatment of ALI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The control, model, and -9MUFAs groups consisted of 18 female Sprageue-Dawley\n(SD) young rats (180 \u00b1 20 g). The SD young rats received normal saline and were not operated.\nLPS-induced ALI animals received tail vein injections of normal saline. SD young rats were first\ntriggered with acute lung injury by LPS (3 mg\/kg) and then injected with 3 mg\/kg of \u03c9-9MUFAs\nvia the tail vein. The expression levels of IL-6, an activator of signal transduction transcription 3\n(STAT3), transforming growth factor-\u03b2 (TGF-\u03b2), and glycoprotein 130 (GP130) in serum and lung\ntissues were determined by ELISA and Western blot methods.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Compared with the model group, the survival rate of rats in the \u03c9-9 MUFAs group was\nsignificantly increased, and the difference was statistically significant (p&lt;0.05). Compared with the\nmodel group, the lung pathology of rats in the \u03c9-9 MUFAs group was significantly improved, and\nthe expression levels of IL-6, TGF-\u03b21, GP130, IL-1 and other proteins were significantly\ndecreased. The difference was statistically significant (p&lt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In LPS-induced lung injury, \u03c9-9MUFAs may alleviate symptoms by inhibiting the\nIL-6\/GP130\/STAT3 pathway.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1386207326666230718154641","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T06:35:25Z","timestamp":1689748525000},"page":"877-884","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of \u03c9-9MUFAs in Fat Emulsion on Serum Interleukin-6 in Rats with\nLipopolysaccharide-induced Lung Injury"],"prefix":"10.2174","volume":"27","author":[{"given":"Zheng","family":"Qianqian","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Qingfeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Xiufen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zejun","sequence":"additional","affiliation":[{"name":"Central Laboratory, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yahong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Mingwei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanmen People's Hospital, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"h2538","DOI":"10.1136\/bmj.h2538","volume":"350","author":"Salluh J.I.F.","year":"2015","unstructured":"Salluh J.I.F.; Wang H.; Schneider E.B.; Nagaraja N.; Yenokyan G.; Damluji A.; Serafim R.B.; Stevens R.D.; Outcome of delirium in critically ill patients: Systematic review and meta-analysis. 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