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Consequently, the loss function of\nkisspeptin or GPR54 leads to a symptom of Hypogonadotropic Hypogonadism (HH) in human and HH accompanied\nby lower gonadotrophic hormone levels, smaller testes, impaired spermatogenesis and abnormal sexual maturation in\nmice. Besides its well-recognized functions in hypothalamus before and during puberty, accumulating data strongly\nsupport kisspeptin production in testis, and participation in somatic and germ cell development and sperm functions\nas well. This review aims to summarize recent findings regarding kisspeptin activity in the testes and sperm function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We undertook a keyword search of peer-reviewed research literature including data from in vivo and\nin vitro studies in humans and genetically modified animal models to identify the roles of kisspeptins in male\nreproduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A plethora of studies detail the role of kisspeptins and GPR54 in mammalian spermatogenesis in vivo and in\nvitro. This review identified recent findings regarding the kisspeptin system in male gonads, and regulation of kisspeptin\nin testicular physiology and male reproductive defects and disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings of this review confirm the importance role of kisspeptins in male fertility. Understanding\ntheir biphasic roles in testis may help to consider kisspeptins as potential pharmacological targets for treating human\ninfertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389200219666180129112406","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T05:49:54Z","timestamp":1517291394000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Kisspeptin and its Effect on Mammalian Spermatogensis"],"prefix":"10.2174","volume":"20","author":[{"given":"Tao","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia H.","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao L.","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0074-7696(02)18012-0","volume":"218","author":"Pierantoni R.","year":"2002","unstructured":"Pierantoni R, Cobellis G, Meccariello R, Fasano S.  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