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Gastric cancer (GC) is widely believed to evolve from gastritis and gastric ulcer. As\nan important adhesion molecule of epithelial cells, E-cadherin plays a key role in the development of gastric diseases. In\nthis review, we aim to seek the characteristic of E-cadherin expression at different stages of gastric diseases.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> We searched plenty of databases for research literature about E-cadherin expression in H. pylori-related\ngastric diseases, and reviewed the relationship of E-cadherin and H. pylori, and the role of E-cadherin at different\nstages of gastric diseases.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> H. pylori was shown to decrease E-cadherin expression by various ways in vitro, while most of clinical\nstudies have not found the relationship between H. pylori and E-cadherin expression. It is defined that poor outcome\nof GC is related to loss expression of E-cadherin, but it is still unclear when qualitative change of E-cadherin expression\nin gastric mucosa emerges.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Expression level of E-cadherin in gastric cells may be a consequence of injury factors and body\u2019s selfrepairing\nability. More studies on E-cadherin expression in gastric mucosa with precancerous lesions need to be\nperformed, which may be potential and useful for early detection, prevention and treatment of GC.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1389200219666180625113010","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T07:43:15Z","timestamp":1529912595000},"page":"23-28","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of E-cadherin in Helicobacter pylori-Related Gastric Diseases"],"prefix":"10.2174","volume":"20","author":[{"given":"Yunzhan","family":"Zhang","sequence":"first","affiliation":[{"name":"Piwei Institute, Guangzhou University of Chinese Medicine, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyan","family":"Li","sequence":"additional","affiliation":[{"name":"Piwei Institute, Guangzhou University of Chinese Medicine, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunkai","family":"Dai","sequence":"additional","affiliation":[{"name":"Piwei Institute, Guangzhou University of Chinese Medicine, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruliu","family":"Li","sequence":"additional","affiliation":[{"name":"Piwei Institute, Guangzhou University of Chinese Medicine, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Piwei Institute, Guangzhou University of Chinese Medicine, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Piwei Institute, Guangzhou University of Chinese Medicine, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/0140-6736(93)90938-D","volume":"341","author":"","year":"1993","unstructured":".  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